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Gene: DNTTIP2 |
Gene summary for DNTTIP2 |
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Gene information | Species | Human | Gene symbol | DNTTIP2 | Gene ID | 30836 |
Gene name | deoxynucleotidyltransferase terminal interacting protein 2 | |
Gene Alias | ERBP | |
Cytomap | 1p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5QJE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
30836 | DNTTIP2 | AEH-subject2 | Human | Endometrium | AEH | 3.56e-06 | -1.29e-01 | -0.2525 |
30836 | DNTTIP2 | AEH-subject3 | Human | Endometrium | AEH | 5.30e-03 | -5.44e-02 | -0.2576 |
30836 | DNTTIP2 | EEC-subject1 | Human | Endometrium | EEC | 1.17e-02 | -9.39e-02 | -0.2682 |
30836 | DNTTIP2 | EEC-subject2 | Human | Endometrium | EEC | 3.13e-05 | -1.33e-01 | -0.2607 |
30836 | DNTTIP2 | EEC-subject3 | Human | Endometrium | EEC | 9.30e-09 | -3.45e-02 | -0.2525 |
30836 | DNTTIP2 | GSM5276934 | Human | Endometrium | EEC | 8.34e-38 | 7.89e-01 | -0.0913 |
30836 | DNTTIP2 | GSM5276937 | Human | Endometrium | EEC | 2.40e-40 | 7.73e-01 | -0.0897 |
30836 | DNTTIP2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.96e-13 | -5.94e-02 | -0.1869 |
30836 | DNTTIP2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.83e-16 | -5.74e-02 | -0.1875 |
30836 | DNTTIP2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.50e-12 | 1.09e-02 | -0.1883 |
30836 | DNTTIP2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.59e-09 | 9.27e-03 | -0.1934 |
30836 | DNTTIP2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.55e-21 | -1.18e-01 | -0.1917 |
30836 | DNTTIP2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 8.64e-15 | -1.03e-01 | -0.1916 |
30836 | DNTTIP2 | LZE4T | Human | Esophagus | ESCC | 1.50e-08 | 6.31e-01 | 0.0811 |
30836 | DNTTIP2 | LZE7T | Human | Esophagus | ESCC | 1.25e-02 | 7.24e-01 | 0.0667 |
30836 | DNTTIP2 | LZE8T | Human | Esophagus | ESCC | 9.13e-17 | -8.80e-02 | 0.067 |
30836 | DNTTIP2 | LZE20T | Human | Esophagus | ESCC | 7.29e-10 | 4.79e-02 | 0.0662 |
30836 | DNTTIP2 | LZE22D1 | Human | Esophagus | HGIN | 4.14e-03 | -2.43e-01 | 0.0595 |
30836 | DNTTIP2 | LZE22T | Human | Esophagus | ESCC | 7.58e-03 | -9.96e-03 | 0.068 |
30836 | DNTTIP2 | LZE24T | Human | Esophagus | ESCC | 1.22e-10 | 2.09e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNTTIP2 | SNV | Missense_Mutation | c.1261G>C | p.Glu421Gln | p.E421Q | Q5QJE6 | protein_coding | deleterious(0.02) | possibly_damaging(0.654) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DNTTIP2 | SNV | Missense_Mutation | rs758634381 | c.2135G>T | p.Arg712Ile | p.R712I | Q5QJE6 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNTTIP2 | SNV | Missense_Mutation | rs867761391 | c.211A>G | p.Thr71Ala | p.T71A | Q5QJE6 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNTTIP2 | SNV | Missense_Mutation | c.431N>T | p.Glu144Val | p.E144V | Q5QJE6 | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
DNTTIP2 | SNV | Missense_Mutation | c.598N>G | p.Thr200Ala | p.T200A | Q5QJE6 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
DNTTIP2 | SNV | Missense_Mutation | c.1934N>T | p.Trp645Leu | p.W645L | Q5QJE6 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-D8-A1XS-01 | Breast | breast invasive carcinoma | Male | <65 | III/IV | Chemotherapy | adriamycin+cyclophosphamide | SD | |
DNTTIP2 | SNV | Missense_Mutation | novel | c.1375N>C | p.Glu459Gln | p.E459Q | Q5QJE6 | protein_coding | deleterious(0.03) | probably_damaging(0.973) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DNTTIP2 | SNV | Missense_Mutation | c.676N>C | p.Glu226Gln | p.E226Q | Q5QJE6 | protein_coding | tolerated(0.07) | benign(0.03) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DNTTIP2 | SNV | Missense_Mutation | novel | c.179N>T | p.Arg60Ile | p.R60I | Q5QJE6 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DNTTIP2 | insertion | Nonsense_Mutation | novel | c.1047_1048insCACTTATAACT | p.Val350HisfsTer3 | p.V350Hfs*3 | Q5QJE6 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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