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Gene: DNASE1 |
Gene summary for DNASE1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DNASE1 | Gene ID | 1773 |
| Gene name | deoxyribonuclease 1 | |
| Gene Alias | DNL1 | |
| Cytomap | 16p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0000737 | UniProtAcc | P24855 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1773 | DNASE1 | LZE7T | Human | Esophagus | ESCC | 1.11e-04 | 2.25e-01 | 0.0667 |
| 1773 | DNASE1 | LZE24T | Human | Esophagus | ESCC | 1.49e-04 | 1.22e-01 | 0.0596 |
| 1773 | DNASE1 | P1T-E | Human | Esophagus | ESCC | 8.60e-05 | 1.97e-01 | 0.0875 |
| 1773 | DNASE1 | P2T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.92e-01 | 0.1177 |
| 1773 | DNASE1 | P8T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.42e-01 | 0.0889 |
| 1773 | DNASE1 | P11T-E | Human | Esophagus | ESCC | 1.92e-07 | 2.45e-01 | 0.1426 |
| 1773 | DNASE1 | P12T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.64e-01 | 0.1122 |
| 1773 | DNASE1 | P15T-E | Human | Esophagus | ESCC | 1.23e-06 | 1.28e-01 | 0.1149 |
| 1773 | DNASE1 | P16T-E | Human | Esophagus | ESCC | 8.84e-05 | 9.35e-02 | 0.1153 |
| 1773 | DNASE1 | P20T-E | Human | Esophagus | ESCC | 2.11e-05 | 9.48e-02 | 0.1124 |
| 1773 | DNASE1 | P21T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.47e-01 | 0.1617 |
| 1773 | DNASE1 | P22T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.25e-01 | 0.1236 |
| 1773 | DNASE1 | P23T-E | Human | Esophagus | ESCC | 6.17e-05 | 1.27e-01 | 0.108 |
| 1773 | DNASE1 | P26T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.17e-02 | 0.1276 |
| 1773 | DNASE1 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.14e-01 | 0.1055 |
| 1773 | DNASE1 | P28T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.64e-01 | 0.1149 |
| 1773 | DNASE1 | P30T-E | Human | Esophagus | ESCC | 1.11e-06 | 2.87e-01 | 0.137 |
| 1773 | DNASE1 | P31T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.36e-02 | 0.1251 |
| 1773 | DNASE1 | P36T-E | Human | Esophagus | ESCC | 9.76e-04 | 1.72e-01 | 0.1187 |
| 1773 | DNASE1 | P39T-E | Human | Esophagus | ESCC | 8.40e-04 | 9.38e-02 | 0.0894 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
| GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
| GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
| GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
| GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
| GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
| GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
| GO:004670021 | Liver | HCC | heterocycle catabolic process | 299/7958 | 445/18723 | 2.07e-26 | 7.29e-24 | 299 |
| GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
| GO:001943921 | Liver | HCC | aromatic compound catabolic process | 309/7958 | 467/18723 | 1.56e-25 | 4.94e-23 | 309 |
| GO:003465521 | Liver | HCC | nucleobase-containing compound catabolic process | 273/7958 | 407/18723 | 4.84e-24 | 1.23e-21 | 273 |
| GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
| GO:00025262 | Liver | HCC | acute inflammatory response | 62/7958 | 112/18723 | 4.06e-03 | 1.77e-02 | 62 |
| GO:003465517 | Oral cavity | OSCC | nucleobase-containing compound catabolic process | 244/7305 | 407/18723 | 5.38e-18 | 5.49e-16 | 244 |
| GO:004670015 | Oral cavity | OSCC | heterocycle catabolic process | 254/7305 | 445/18723 | 5.07e-15 | 3.31e-13 | 254 |
| GO:004427016 | Oral cavity | OSCC | cellular nitrogen compound catabolic process | 256/7305 | 451/18723 | 9.67e-15 | 5.88e-13 | 256 |
| GO:001943915 | Oral cavity | OSCC | aromatic compound catabolic process | 263/7305 | 467/18723 | 1.49e-14 | 8.84e-13 | 263 |
| GO:190136115 | Oral cavity | OSCC | organic cyclic compound catabolic process | 272/7305 | 495/18723 | 2.73e-13 | 1.36e-11 | 272 |
| GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
| GO:003465518 | Oral cavity | LP | nucleobase-containing compound catabolic process | 161/4623 | 407/18723 | 1.61e-11 | 1.15e-09 | 161 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DNASE1 | SNV | Missense_Mutation | rs148684969 | c.739N>A | p.Val247Ile | p.V247I | P24855 | protein_coding | tolerated(0.59) | benign(0.009) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| DNASE1 | SNV | Missense_Mutation | c.608G>T | p.Trp203Leu | p.W203L | P24855 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| DNASE1 | SNV | Missense_Mutation | c.313N>A | p.Val105Met | p.V105M | P24855 | protein_coding | deleterious(0) | possibly_damaging(0.656) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| DNASE1 | SNV | Missense_Mutation | c.237N>T | p.Gln79His | p.Q79H | P24855 | protein_coding | deleterious(0.05) | benign(0.2) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
| DNASE1 | SNV | Missense_Mutation | rs141673463 | c.76N>A | p.Ala26Thr | p.A26T | P24855 | protein_coding | tolerated(0.11) | possibly_damaging(0.547) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| DNASE1 | SNV | Missense_Mutation | novel | c.26N>T | p.Ala9Val | p.A9V | P24855 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| DNASE1 | SNV | Missense_Mutation | novel | c.562N>G | p.Met188Val | p.M188V | P24855 | protein_coding | deleterious(0) | benign(0.285) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
| DNASE1 | SNV | Missense_Mutation | novel | c.124A>G | p.Thr42Ala | p.T42A | P24855 | protein_coding | tolerated(0.34) | possibly_damaging(0.802) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
| DNASE1 | SNV | Missense_Mutation | novel | c.133A>G | p.Ser45Gly | p.S45G | P24855 | protein_coding | tolerated(0.3) | benign(0.017) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| DNASE1 | SNV | Missense_Mutation | rs767031004 | c.691N>C | p.Cys231Arg | p.C231R | P24855 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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