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Gene: DNAJC12 |
Gene summary for DNAJC12 |
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Gene information | Species | Human | Gene symbol | DNAJC12 | Gene ID | 56521 |
Gene name | DnaJ heat shock protein family (Hsp40) member C12 | |
Gene Alias | HPANBH4 | |
Cytomap | 10q21.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6IAH1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56521 | DNAJC12 | GSM4909281 | Human | Breast | IDC | 1.29e-11 | -3.06e-01 | 0.21 |
56521 | DNAJC12 | GSM4909282 | Human | Breast | IDC | 9.68e-04 | -2.51e-01 | -0.0288 |
56521 | DNAJC12 | GSM4909285 | Human | Breast | IDC | 6.47e-04 | -2.17e-01 | 0.21 |
56521 | DNAJC12 | GSM4909286 | Human | Breast | IDC | 4.12e-17 | -3.25e-01 | 0.1081 |
56521 | DNAJC12 | GSM4909287 | Human | Breast | IDC | 3.71e-10 | -3.04e-01 | 0.2057 |
56521 | DNAJC12 | GSM4909290 | Human | Breast | IDC | 1.72e-05 | -3.07e-01 | 0.2096 |
56521 | DNAJC12 | GSM4909296 | Human | Breast | IDC | 7.30e-11 | -3.04e-01 | 0.1524 |
56521 | DNAJC12 | GSM4909297 | Human | Breast | IDC | 3.47e-07 | 1.52e-01 | 0.1517 |
56521 | DNAJC12 | GSM4909308 | Human | Breast | IDC | 1.55e-05 | 1.60e-01 | 0.158 |
56521 | DNAJC12 | GSM4909311 | Human | Breast | IDC | 7.02e-12 | -2.45e-01 | 0.1534 |
56521 | DNAJC12 | GSM4909312 | Human | Breast | IDC | 7.68e-06 | -2.35e-01 | 0.1552 |
56521 | DNAJC12 | GSM4909315 | Human | Breast | IDC | 2.69e-13 | -3.19e-01 | 0.21 |
56521 | DNAJC12 | GSM4909316 | Human | Breast | IDC | 8.95e-03 | -3.26e-01 | 0.21 |
56521 | DNAJC12 | GSM4909317 | Human | Breast | IDC | 2.73e-02 | -2.38e-01 | 0.1355 |
56521 | DNAJC12 | GSM4909319 | Human | Breast | IDC | 1.73e-17 | -3.07e-01 | 0.1563 |
56521 | DNAJC12 | GSM4909321 | Human | Breast | IDC | 2.02e-06 | -2.01e-01 | 0.1559 |
56521 | DNAJC12 | brca1 | Human | Breast | Precancer | 9.68e-08 | -2.68e-01 | -0.0338 |
56521 | DNAJC12 | brca3 | Human | Breast | Precancer | 2.37e-04 | 3.26e-01 | -0.0263 |
56521 | DNAJC12 | brca10 | Human | Breast | Precancer | 2.50e-07 | 4.48e-01 | -0.0029 |
56521 | DNAJC12 | NCCBC3 | Human | Breast | DCIS | 1.98e-03 | -1.75e-01 | 0.1198 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC12 | SNV | Missense_Mutation | c.358C>T | p.His120Tyr | p.H120Y | Q9UKB3 | protein_coding | tolerated(1) | benign(0) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DNAJC12 | SNV | Missense_Mutation | c.298N>C | p.Ser100Pro | p.S100P | Q9UKB3 | protein_coding | deleterious(0) | possibly_damaging(0.566) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DNAJC12 | SNV | Missense_Mutation | c.497N>A | p.Ser166Tyr | p.S166Y | Q9UKB3 | protein_coding | tolerated(0.08) | possibly_damaging(0.832) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DNAJC12 | SNV | Missense_Mutation | novel | c.137N>G | p.His46Arg | p.H46R | Q9UKB3 | protein_coding | deleterious(0.01) | possibly_damaging(0.604) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
DNAJC12 | SNV | Missense_Mutation | novel | c.512A>G | p.Asp171Gly | p.D171G | Q9UKB3 | protein_coding | tolerated(0.09) | benign(0.024) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAJC12 | SNV | Missense_Mutation | rs200719110 | c.440C>T | p.Thr147Met | p.T147M | Q9UKB3 | protein_coding | tolerated(0.2) | benign(0) | TCGA-CM-5341-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
DNAJC12 | insertion | Nonsense_Mutation | novel | c.13_14insCTTAAATAAAAACT | p.Leu5ProfsTer2 | p.L5Pfs*2 | Q9UKB3 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DNAJC12 | SNV | Missense_Mutation | novel | c.376N>T | p.Asn126Tyr | p.N126Y | Q9UKB3 | protein_coding | deleterious(0.03) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC12 | SNV | Missense_Mutation | novel | c.12N>G | p.Ile4Met | p.I4M | Q9UKB3 | protein_coding | deleterious(0.05) | probably_damaging(0.954) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DNAJC12 | SNV | Missense_Mutation | rs769789184 | c.221N>A | p.Arg74His | p.R74H | Q9UKB3 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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