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Gene: DMRT2 |
Gene summary for DMRT2 |
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Gene information | Species | Human | Gene symbol | DMRT2 | Gene ID | 10655 |
Gene name | doublesex and mab-3 related transcription factor 2 | |
Gene Alias | DSXL-2 | |
Cytomap | 9p24.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q05C20 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10655 | DMRT2 | C30 | Human | Oral cavity | OSCC | 5.50e-35 | 1.13e+00 | 0.3055 |
10655 | DMRT2 | C38 | Human | Oral cavity | OSCC | 1.53e-02 | 7.48e-01 | 0.172 |
10655 | DMRT2 | C57 | Human | Oral cavity | OSCC | 1.04e-02 | 1.44e-01 | 0.1679 |
10655 | DMRT2 | C08 | Human | Oral cavity | OSCC | 3.94e-04 | 1.02e-01 | 0.1919 |
10655 | DMRT2 | SYSMH1 | Human | Oral cavity | OSCC | 2.01e-07 | 1.68e-01 | 0.1127 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMRT2 | SNV | Missense_Mutation | c.1413N>A | p.Phe471Leu | p.F471L | Q9Y5R5 | protein_coding | deleterious_low_confidence(0.01) | benign(0.048) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DMRT2 | SNV | Missense_Mutation | c.968N>A | p.Ser323Tyr | p.S323Y | Q9Y5R5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DMRT2 | SNV | Missense_Mutation | novel | c.1615G>A | p.Glu539Lys | p.E539K | Q9Y5R5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
DMRT2 | deletion | Frame_Shift_Del | c.596delN | p.Ser201ValfsTer8 | p.S201Vfs*8 | Q9Y5R5 | protein_coding | TCGA-AO-A12F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |||
DMRT2 | SNV | Missense_Mutation | novel | c.988A>C | p.Thr330Pro | p.T330P | Q9Y5R5 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.844) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DMRT2 | SNV | Missense_Mutation | rs140044845 | c.635N>A | p.Arg212His | p.R212H | Q9Y5R5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DMRT2 | SNV | Missense_Mutation | c.755G>T | p.Arg252Ile | p.R252I | Q9Y5R5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
DMRT2 | SNV | Missense_Mutation | rs140044845 | c.635N>A | p.Arg212His | p.R212H | Q9Y5R5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-4614-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DMRT2 | SNV | Missense_Mutation | c.910N>T | p.Pro304Ser | p.P304S | Q9Y5R5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DMRT2 | SNV | Missense_Mutation | c.1305N>G | p.Asn435Lys | p.N435K | Q9Y5R5 | protein_coding | deleterious_low_confidence(0.03) | benign(0.19) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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