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Gene: DMBX1 |
Gene summary for DMBX1 |
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Gene information | Species | Human | Gene symbol | DMBX1 | Gene ID | 127343 |
Gene name | diencephalon/mesencephalon homeobox 1 | |
Gene Alias | MBX | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8NFW5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
127343 | DMBX1 | HCC2 | Human | Liver | HCC | 2.33e-16 | 1.18e+00 | 0.5341 |
127343 | DMBX1 | HCC5 | Human | Liver | HCC | 5.98e-15 | 1.11e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMBX1 | SNV | Missense_Mutation | rs761306825 | c.779G>A | p.Arg260His | p.R260H | Q8NFW5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-A2-A4S3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DMBX1 | SNV | Missense_Mutation | novel | c.291G>T | p.Glu97Asp | p.E97D | Q8NFW5 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
DMBX1 | SNV | Missense_Mutation | c.199C>T | p.Arg67Cys | p.R67C | Q8NFW5 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DMBX1 | SNV | Missense_Mutation | novel | c.770G>A | p.Ser257Asn | p.S257N | Q8NFW5 | protein_coding | tolerated(0.13) | possibly_damaging(0.894) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DMBX1 | SNV | Missense_Mutation | rs200058413 | c.1121C>T | p.Thr374Met | p.T374M | Q8NFW5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.983) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DMBX1 | SNV | Missense_Mutation | c.689C>A | p.Pro230Gln | p.P230Q | Q8NFW5 | protein_coding | deleterious(0) | possibly_damaging(0.784) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD | |
DMBX1 | SNV | Missense_Mutation | novel | c.209N>A | p.Arg70His | p.R70H | Q8NFW5 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
DMBX1 | SNV | Missense_Mutation | rs114953520 | c.377N>A | p.Arg126His | p.R126H | Q8NFW5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
DMBX1 | SNV | Missense_Mutation | rs763846022 | c.191G>A | p.Arg64His | p.R64H | Q8NFW5 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DMBX1 | SNV | Missense_Mutation | c.427C>T | p.His143Tyr | p.H143Y | Q8NFW5 | protein_coding | deleterious(0.04) | benign(0.059) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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