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Gene: DLX4 |
Gene summary for DLX4 |
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Gene information | Species | Human | Gene symbol | DLX4 | Gene ID | 1748 |
Gene name | distal-less homeobox 4 | |
Gene Alias | BP1 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q92988 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1748 | DLX4 | C30 | Human | Oral cavity | OSCC | 7.35e-14 | 7.26e-01 | 0.3055 |
1748 | DLX4 | C43 | Human | Oral cavity | OSCC | 1.33e-03 | 1.75e-01 | 0.1704 |
1748 | DLX4 | C08 | Human | Oral cavity | OSCC | 1.27e-02 | 1.83e-01 | 0.1919 |
1748 | DLX4 | LP17 | Human | Oral cavity | LP | 3.21e-04 | 7.02e-01 | 0.2349 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DLX4 | insertion | In_Frame_Ins | novel | c.517_518insTGTGCTGCCCACCAGACTCGG | p.Lys173delinsMetCysCysProProAspSerGlu | p.K173delinsMCCPPDSE | Q92988 | protein_coding | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DLX4 | SNV | Missense_Mutation | rs202154782 | c.707C>T | p.Ser236Leu | p.S236L | Q92988 | protein_coding | tolerated(0.44) | benign(0) | TCGA-ZJ-AAXF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DLX4 | SNV | Missense_Mutation | novel | c.595C>T | p.Pro199Ser | p.P199S | Q92988 | protein_coding | tolerated(0.08) | benign(0.236) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DLX4 | SNV | Missense_Mutation | c.539C>A | p.Ser180Tyr | p.S180Y | Q92988 | protein_coding | deleterious(0) | possibly_damaging(0.594) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
DLX4 | SNV | Missense_Mutation | rs202154782 | c.707C>T | p.Ser236Leu | p.S236L | Q92988 | protein_coding | tolerated(0.44) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
DLX4 | SNV | Missense_Mutation | c.13N>T | p.Pro5Ser | p.P5S | Q92988 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DLX4 | SNV | Missense_Mutation | novel | c.284A>G | p.Asp95Gly | p.D95G | Q92988 | protein_coding | tolerated(0.08) | benign(0) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DLX4 | SNV | Missense_Mutation | novel | c.285C>A | p.Asp95Glu | p.D95E | Q92988 | protein_coding | tolerated(0.71) | benign(0) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DLX4 | SNV | Missense_Mutation | c.359N>T | p.Pro120Leu | p.P120L | Q92988 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DLX4 | SNV | Missense_Mutation | c.148C>T | p.Pro50Ser | p.P50S | Q92988 | protein_coding | tolerated(0.38) | benign(0) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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