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Gene: DLK1 |
Gene summary for DLK1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DLK1 | Gene ID | 8788 |
| Gene name | delta like non-canonical Notch ligand 1 | |
| Gene Alias | DLK | |
| Cytomap | 14q32.2 | |
| Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A8K019 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8788 | DLK1 | LP16 | Human | Oral cavity | LP | 4.45e-04 | 2.01e+00 | 0.1055 |
| 8788 | DLK1 | ATC13 | Human | Thyroid | ATC | 4.14e-42 | 1.96e+00 | 0.34 |
| 8788 | DLK1 | ATC5 | Human | Thyroid | ATC | 6.38e-48 | 2.09e+00 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000859311 | Oral cavity | LP | regulation of Notch signaling pathway | 35/4623 | 95/18723 | 5.53e-03 | 3.34e-02 | 35 |
| GO:000721913 | Oral cavity | LP | Notch signaling pathway | 57/4623 | 172/18723 | 7.60e-03 | 4.18e-02 | 57 |
| GO:000721915 | Thyroid | ATC | Notch signaling pathway | 79/6293 | 172/18723 | 5.08e-04 | 2.96e-03 | 79 |
| GO:00085937 | Thyroid | ATC | regulation of Notch signaling pathway | 43/6293 | 95/18723 | 1.19e-02 | 4.22e-02 | 43 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| DLK1 | NOTCH2 | DLK1_NOTCH2 | NOTCH | Breast | ADJ |
| DLK1 | NOTCH2 | DLK1_NOTCH2 | NOTCH | Breast | Healthy |
| DLK1 | NOTCH3 | DLK1_NOTCH3 | NOTCH | Breast | Healthy |
| DLK1 | NOTCH4 | DLK1_NOTCH4 | NOTCH | Breast | Healthy |
| DLK1 | NOTCH1 | DLK1_NOTCH1 | NOTCH | HNSCC | ADJ |
| DLK1 | NOTCH2 | DLK1_NOTCH2 | NOTCH | HNSCC | ADJ |
| DLK1 | NOTCH3 | DLK1_NOTCH3 | NOTCH | HNSCC | ADJ |
| DLK1 | NOTCH4 | DLK1_NOTCH4 | NOTCH | HNSCC | ADJ |
| DLK1 | NOTCH1 | DLK1_NOTCH1 | NOTCH | THCA | Cancer |
| DLK1 | NOTCH2 | DLK1_NOTCH2 | NOTCH | THCA | Cancer |
| DLK1 | NOTCH3 | DLK1_NOTCH3 | NOTCH | THCA | Cancer |
| DLK1 | NOTCH4 | DLK1_NOTCH4 | NOTCH | THCA | Cancer |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DLK1 | SNV | Missense_Mutation | rs146800507 | c.1066N>A | p.Gly356Arg | p.G356R | P80370 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-B6-A0X4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| DLK1 | deletion | Frame_Shift_Del | c.828delN | p.Val277CysfsTer9 | p.V277Cfs*9 | P80370 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
| DLK1 | deletion | Frame_Shift_Del | c.474delN | p.Pro160LeufsTer50 | p.P160Lfs*50 | P80370 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
| DLK1 | SNV | Missense_Mutation | rs767836232 | c.583C>T | p.Arg195Trp | p.R195W | P80370 | protein_coding | tolerated(0.1) | probably_damaging(1) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| DLK1 | SNV | Missense_Mutation | c.190C>A | p.Leu64Ile | p.L64I | P80370 | protein_coding | tolerated(0.07) | benign(0.03) | TCGA-A6-6142-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | PD | |
| DLK1 | SNV | Missense_Mutation | c.452C>T | p.Ala151Val | p.A151V | P80370 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| DLK1 | SNV | Missense_Mutation | c.538G>A | p.Glu180Lys | p.E180K | P80370 | protein_coding | tolerated(0.47) | probably_damaging(0.998) | TCGA-AA-3850-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| DLK1 | SNV | Missense_Mutation | novel | c.844N>G | p.His282Asp | p.H282D | P80370 | protein_coding | deleterious(0.01) | benign(0.186) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| DLK1 | SNV | Missense_Mutation | c.848N>A | p.Arg283His | p.R283H | P80370 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| DLK1 | SNV | Missense_Mutation | c.532N>A | p.Pro178Thr | p.P178T | P80370 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 8788 | DLK1 | DRUGGABLE GENOME | GDC0134 |
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