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Gene: DHX58 |
Gene summary for DHX58 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DHX58 | Gene ID | 79132 |
| Gene name | DExH-box helicase 58 | |
| Gene Alias | D11LGP2 | |
| Cytomap | 17q21.2 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | A0A024R1Y5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79132 | DHX58 | C21 | Human | Oral cavity | OSCC | 2.18e-07 | 3.82e-01 | 0.2678 |
| 79132 | DHX58 | C30 | Human | Oral cavity | OSCC | 2.09e-15 | 7.81e-01 | 0.3055 |
| 79132 | DHX58 | C38 | Human | Oral cavity | OSCC | 3.24e-05 | 6.51e-01 | 0.172 |
| 79132 | DHX58 | C46 | Human | Oral cavity | OSCC | 1.84e-07 | 2.91e-01 | 0.1673 |
| 79132 | DHX58 | C51 | Human | Oral cavity | OSCC | 4.36e-02 | 2.75e-01 | 0.2674 |
| 79132 | DHX58 | C08 | Human | Oral cavity | OSCC | 1.70e-03 | 2.22e-01 | 0.1919 |
| 79132 | DHX58 | LN46 | Human | Oral cavity | OSCC | 1.95e-14 | 6.27e-01 | 0.1666 |
| 79132 | DHX58 | SYSMH3 | Human | Oral cavity | OSCC | 1.03e-03 | 1.81e-01 | 0.2442 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000961515 | Oral cavity | OSCC | response to virus | 215/7305 | 367/18723 | 1.63e-14 | 9.41e-13 | 215 |
| GO:00516074 | Oral cavity | OSCC | defense response to virus | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
| GO:01405464 | Oral cavity | OSCC | defense response to symbiont | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
| GO:003052218 | Oral cavity | OSCC | intracellular receptor signaling pathway | 149/7305 | 265/18723 | 8.69e-09 | 1.81e-07 | 149 |
| GO:00028317 | Oral cavity | OSCC | regulation of response to biotic stimulus | 177/7305 | 327/18723 | 1.73e-08 | 3.43e-07 | 177 |
| GO:00028324 | Oral cavity | OSCC | negative regulation of response to biotic stimulus | 65/7305 | 108/18723 | 6.62e-06 | 7.29e-05 | 65 |
| GO:00022214 | Oral cavity | OSCC | pattern recognition receptor signaling pathway | 95/7305 | 172/18723 | 1.11e-05 | 1.15e-04 | 95 |
| GO:00027537 | Oral cavity | OSCC | cytoplasmic pattern recognition receptor signaling pathway | 40/7305 | 60/18723 | 1.32e-05 | 1.33e-04 | 40 |
| GO:00450884 | Oral cavity | OSCC | regulation of innate immune response | 116/7305 | 218/18723 | 1.36e-05 | 1.37e-04 | 116 |
| GO:00326083 | Oral cavity | OSCC | interferon-beta production | 37/7305 | 56/18723 | 3.74e-05 | 3.32e-04 | 37 |
| GO:00326483 | Oral cavity | OSCC | regulation of interferon-beta production | 37/7305 | 56/18723 | 3.74e-05 | 3.32e-04 | 37 |
| GO:00324816 | Oral cavity | OSCC | positive regulation of type I interferon production | 38/7305 | 58/18723 | 3.91e-05 | 3.43e-04 | 38 |
| GO:00327283 | Oral cavity | OSCC | positive regulation of interferon-beta production | 27/7305 | 39/18723 | 1.27e-04 | 9.09e-04 | 27 |
| GO:00321037 | Oral cavity | OSCC | positive regulation of response to external stimulus | 203/7305 | 427/18723 | 1.79e-04 | 1.22e-03 | 203 |
| GO:00395283 | Oral cavity | OSCC | cytoplasmic pattern recognition receptor signaling pathway in response to virus | 24/7305 | 34/18723 | 1.89e-04 | 1.28e-03 | 24 |
| GO:00506883 | Oral cavity | OSCC | regulation of defense response to virus | 42/7305 | 69/18723 | 1.92e-04 | 1.29e-03 | 42 |
| GO:00324793 | Oral cavity | OSCC | regulation of type I interferon production | 54/7305 | 95/18723 | 3.17e-04 | 1.97e-03 | 54 |
| GO:00326063 | Oral cavity | OSCC | type I interferon production | 54/7305 | 95/18723 | 3.17e-04 | 1.97e-03 | 54 |
| GO:000268310 | Oral cavity | OSCC | negative regulation of immune system process | 204/7305 | 434/18723 | 3.72e-04 | 2.27e-03 | 204 |
| GO:00395301 | Oral cavity | OSCC | MDA-5 signaling pathway | 10/7305 | 11/18723 | 5.78e-04 | 3.30e-03 | 10 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04622 | Oral cavity | OSCC | RIG-I-like receptor signaling pathway | 41/3704 | 71/8465 | 1.20e-02 | 2.63e-02 | 1.34e-02 | 41 |
| hsa046221 | Oral cavity | OSCC | RIG-I-like receptor signaling pathway | 41/3704 | 71/8465 | 1.20e-02 | 2.63e-02 | 1.34e-02 | 41 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DHX58 | SNV | Missense_Mutation | c.872N>A | p.Leu291Gln | p.L291Q | Q96C10 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |
| DHX58 | SNV | Missense_Mutation | c.1243N>G | p.Met415Val | p.M415V | Q96C10 | protein_coding | deleterious(0) | possibly_damaging(0.478) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DHX58 | SNV | Missense_Mutation | novel | c.1489N>C | p.Glu497Gln | p.E497Q | Q96C10 | protein_coding | deleterious(0.01) | probably_damaging(0.952) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| DHX58 | SNV | Missense_Mutation | rs553858409 | c.1322N>T | p.Ala441Val | p.A441V | Q96C10 | protein_coding | deleterious(0.01) | benign(0.303) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
| DHX58 | insertion | Frame_Shift_Ins | novel | c.399_400insAGGTCACTTGCTATGTATCCAAGCCTCAATTT | p.His134ArgfsTer24 | p.H134Rfs*24 | Q96C10 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| DHX58 | insertion | Nonsense_Mutation | novel | c.1614_1615insTGTAATTCCAACACTTTGGGAGGCGGAGGTGGGTAGATCA | p.Gln539CysfsTer12 | p.Q539Cfs*12 | Q96C10 | protein_coding | TCGA-B6-A0IM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| DHX58 | SNV | Missense_Mutation | c.1324N>A | p.Glu442Lys | p.E442K | Q96C10 | protein_coding | deleterious(0.02) | probably_damaging(0.94) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
| DHX58 | SNV | Missense_Mutation | c.1752C>G | p.Phe584Leu | p.F584L | Q96C10 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| DHX58 | SNV | Missense_Mutation | novel | c.1661N>C | p.Leu554Pro | p.L554P | Q96C10 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3696-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
| DHX58 | SNV | Missense_Mutation | c.1156N>C | p.Trp386Arg | p.W386R | Q96C10 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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