Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DGKH

Gene summary for DGKH

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DGKH

Gene ID

160851

Gene namediacylglycerol kinase eta
Gene AliasDGKeta
Cytomap13q14.11
Gene Typeprotein-coding
GO ID

GO:0001775

UniProtAcc

A8K0I1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
160851DGKHCCI_1HumanCervixCC2.99e-201.89e+000.528
160851DGKHCCI_2HumanCervixCC1.25e-141.41e+000.5249
160851DGKHCCI_3HumanCervixCC2.80e-221.37e+000.516
160851DGKHsample3HumanCervixCC1.22e-021.75e-010.1387
160851DGKHT3HumanCervixCC2.51e-041.70e-010.1389
160851DGKHHTA11_3410_2000001011HumanColorectumAD1.50e-27-7.54e-010.0155
160851DGKHHTA11_2487_2000001011HumanColorectumSER8.00e-06-5.08e-01-0.1808
160851DGKHHTA11_2951_2000001011HumanColorectumAD1.43e-03-8.45e-010.0216
160851DGKHHTA11_3361_2000001011HumanColorectumAD1.37e-11-8.08e-01-0.1207
160851DGKHHTA11_83_2000001011HumanColorectumSER8.31e-04-4.50e-01-0.1526
160851DGKHHTA11_5212_2000001011HumanColorectumAD3.87e-04-4.94e-01-0.2061
160851DGKHHTA11_5216_2000001011HumanColorectumSER1.05e-02-7.61e-01-0.1462
160851DGKHHTA11_9341_2000001011HumanColorectumSER5.34e-03-7.28e-01-0.00410000000000005
160851DGKHHTA11_866_3004761011HumanColorectumAD2.22e-16-7.51e-010.096
160851DGKHHTA11_9408_2000001011HumanColorectumAD3.85e-02-7.57e-010.0451
160851DGKHHTA11_8622_2000001021HumanColorectumSER3.03e-04-6.93e-010.0528
160851DGKHHTA11_10711_2000001011HumanColorectumAD1.92e-04-5.89e-010.0338
160851DGKHHTA11_7696_3000711011HumanColorectumAD1.80e-08-4.55e-010.0674
160851DGKHHTA11_99999970781_79442HumanColorectumMSS4.72e-14-5.97e-010.294
160851DGKHHTA11_99999965104_69814HumanColorectumMSS2.59e-056.31e-010.281
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004206010CervixCCwound healing109/2311422/187231.84e-141.57e-11109
GO:005087810CervixCCregulation of body fluid levels78/2311379/187233.20e-068.77e-0578
GO:00508176CervixCCcoagulation45/2311222/187235.08e-044.94e-0345
GO:00075966CervixCCblood coagulation44/2311217/187235.78e-045.52e-0344
GO:00301682CervixCCplatelet activation28/2311123/187238.92e-047.71e-0328
GO:00075996CervixCChemostasis44/2311222/187239.47e-047.95e-0344
GO:0042060ColorectumADwound healing128/3918422/187232.73e-067.89e-05128
GO:0030258ColorectumADlipid modification67/3918212/187231.66e-042.27e-0367
GO:0050878ColorectumADregulation of body fluid levels108/3918379/187232.54e-043.20e-03108
GO:0006650ColorectumADglycerophospholipid metabolic process83/3918306/187235.40e-033.55e-0283
GO:0006644ColorectumADphospholipid metabolic process101/3918383/187235.80e-033.67e-02101
GO:0045017ColorectumADglycerolipid biosynthetic process69/3918252/187238.33e-034.88e-0269
GO:00420601ColorectumSERwound healing97/2897422/187232.69e-057.30e-0497
GO:00508781ColorectumSERregulation of body fluid levels81/2897379/187231.28e-031.43e-0281
GO:0046486ColorectumSERglycerolipid metabolic process82/2897392/187232.26e-032.17e-0282
GO:00066441ColorectumSERphospholipid metabolic process79/2897383/187233.94e-033.24e-0279
GO:00450171ColorectumSERglycerolipid biosynthetic process55/2897252/187234.47e-033.56e-0255
GO:00302581ColorectumSERlipid modification47/2897212/187236.01e-034.38e-0247
GO:00066501ColorectumSERglycerophospholipid metabolic process64/2897306/187236.41e-034.60e-0264
GO:00420602ColorectumMSSwound healing119/3467422/187235.93e-072.24e-05119
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa00561ColorectumADGlycerolipid metabolism24/209263/84651.25e-024.54e-022.90e-0224
hsa005611ColorectumADGlycerolipid metabolism24/209263/84651.25e-024.54e-022.90e-0224
hsa05231ColorectumMSSCholine metabolism in cancer34/187598/84652.90e-031.39e-028.50e-0334
hsa005612ColorectumMSSGlycerolipid metabolism23/187563/84656.55e-032.64e-021.62e-0223
hsa052311ColorectumMSSCholine metabolism in cancer34/187598/84652.90e-031.39e-028.50e-0334
hsa005613ColorectumMSSGlycerolipid metabolism23/187563/84656.55e-032.64e-021.62e-0223
hsa052312ColorectumFAPCholine metabolism in cancer29/140498/84659.03e-045.20e-033.16e-0329
hsa052313ColorectumFAPCholine metabolism in cancer29/140498/84659.03e-045.20e-033.16e-0329
hsa04070ColorectumCRCPhosphatidylinositol signaling system25/109197/84654.27e-044.60e-033.12e-0325
hsa052314ColorectumCRCCholine metabolism in cancer24/109198/84651.21e-039.84e-036.67e-0324
hsa040701ColorectumCRCPhosphatidylinositol signaling system25/109197/84654.27e-044.60e-033.12e-0325
hsa052315ColorectumCRCCholine metabolism in cancer24/109198/84651.21e-039.84e-036.67e-0324
hsa052319EsophagusESCCCholine metabolism in cancer61/420598/84657.97e-031.92e-029.84e-0361
hsa0523114EsophagusESCCCholine metabolism in cancer61/420598/84657.97e-031.92e-029.84e-0361
hsa005615LiverHCCGlycerolipid metabolism41/402063/84653.59e-031.12e-026.22e-0341
hsa052316LiverHCCCholine metabolism in cancer57/402098/84652.14e-024.90e-022.72e-0257
hsa0056112LiverHCCGlycerolipid metabolism41/402063/84653.59e-031.12e-026.22e-0341
hsa0523111LiverHCCCholine metabolism in cancer57/402098/84652.14e-024.90e-022.72e-0257
hsa052317LungIACCholine metabolism in cancer23/105398/84651.72e-039.66e-036.41e-0323
hsa04072LungIACPhospholipase D signaling pathway28/1053148/84651.46e-025.00e-023.32e-0228
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DGKHSNVMissense_Mutationrs747484150c.1390N>Tp.Leu464Phep.L464FQ86XP1protein_codingtolerated(0.71)benign(0.028)TCGA-A7-A4SE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
DGKHSNVMissense_Mutationnovelc.3440N>Ap.Pro1147Hisp.P1147HQ86XP1protein_codingdeleterious(0.03)benign(0.011)TCGA-A8-A08L-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
DGKHSNVMissense_Mutationnovelc.3214N>Ap.Gln1072Lysp.Q1072KQ86XP1protein_codingtolerated(0.28)benign(0.028)TCGA-B6-A40B-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
DGKHSNVMissense_Mutationnovelc.334G>Cp.Asp112Hisp.D112HQ86XP1protein_codingdeleterious(0.01)probably_damaging(0.996)TCGA-BH-A8FZ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
DGKHSNVMissense_Mutationc.715N>Ap.Glu239Lysp.E239KQ86XP1protein_codingdeleterious(0)possibly_damaging(0.596)TCGA-C8-A26Y-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
DGKHSNVMissense_Mutationc.628A>Gp.Lys210Glup.K210EQ86XP1protein_codingdeleterious(0.02)probably_damaging(0.98)TCGA-E9-A245-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
DGKHSNVMissense_Mutationc.2551N>Gp.Pro851Alap.P851AQ86XP1protein_codingdeleterious(0)probably_damaging(0.992)TCGA-GM-A2D9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
DGKHinsertionFrame_Shift_Insnovelc.2032_2033insTCTTGATTCTTTTTGAGTATTTTTCTCATTGCCATATTTTCp.Thr678IlefsTer56p.T678Ifs*56Q86XP1protein_codingTCGA-A2-A0CP-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
DGKHinsertionFrame_Shift_Insnovelc.3441_3442insATTGTCATTGTCGAGGp.Val1148IlefsTer34p.V1148Ifs*34Q86XP1protein_codingTCGA-A8-A08L-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
DGKHinsertionFrame_Shift_Insnovelc.1315_1316insATGGATGTTGGTCTTCTTCAp.Leu439HisfsTer12p.L439Hfs*12Q86XP1protein_codingTCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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