Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DGAT2

Gene summary for DGAT2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DGAT2

Gene ID

84649

Gene namediacylglycerol O-acyltransferase 2
Gene AliasARAT
Cytomap11q13.5
Gene Typeprotein-coding
GO ID

GO:0001523

UniProtAcc

Q96PD7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84649DGAT2LZE24THumanEsophagusESCC2.87e-101.96e-010.0596
84649DGAT2P2T-EHumanEsophagusESCC1.74e-337.39e-010.1177
84649DGAT2P4T-EHumanEsophagusESCC2.17e-081.93e-010.1323
84649DGAT2P10T-EHumanEsophagusESCC1.71e-048.55e-020.116
84649DGAT2P15T-EHumanEsophagusESCC7.46e-067.13e-020.1149
84649DGAT2P16T-EHumanEsophagusESCC3.57e-041.61e-010.1153
84649DGAT2P21T-EHumanEsophagusESCC2.35e-041.14e-010.1617
84649DGAT2P26T-EHumanEsophagusESCC1.85e-031.66e-010.1276
84649DGAT2P27T-EHumanEsophagusESCC2.48e-029.49e-020.1055
84649DGAT2P37T-EHumanEsophagusESCC2.48e-059.84e-020.1371
84649DGAT2P52T-EHumanEsophagusESCC7.14e-041.07e-010.1555
84649DGAT2P62T-EHumanEsophagusESCC7.23e-151.85e-010.1302
84649DGAT2P75T-EHumanEsophagusESCC6.19e-081.64e-010.1125
84649DGAT2P76T-EHumanEsophagusESCC2.83e-029.13e-020.1207
84649DGAT2P79T-EHumanEsophagusESCC3.24e-036.31e-020.1154
84649DGAT2P80T-EHumanEsophagusESCC7.41e-215.84e-010.155
84649DGAT2P82T-EHumanEsophagusESCC2.55e-021.58e-010.1072
84649DGAT2P83T-EHumanEsophagusESCC4.72e-134.49e-010.1738
84649DGAT2P107T-EHumanEsophagusESCC1.69e-041.36e-010.171
84649DGAT2P128T-EHumanEsophagusESCC2.02e-052.16e-010.1241
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0051235110EsophagusESCCmaintenance of location200/8552327/187231.01e-082.02e-07200
GO:0006753110EsophagusESCCnucleoside phosphate metabolic process288/8552497/187231.80e-083.50e-07288
GO:0019693111EsophagusESCCribose phosphate metabolic process234/8552396/187234.24e-087.76e-07234
GO:0009117111EsophagusESCCnucleotide metabolic process282/8552489/187234.70e-088.50e-07282
GO:00059969EsophagusESCCmonosaccharide metabolic process159/8552257/187231.11e-071.81e-06159
GO:00193189EsophagusESCChexose metabolic process147/8552237/187232.63e-073.94e-06147
GO:00067906EsophagusESCCsulfur compound metabolic process201/8552339/187232.64e-073.94e-06201
GO:0009259111EsophagusESCCribonucleotide metabolic process224/8552385/187234.41e-076.00e-06224
GO:00450175EsophagusESCCglycerolipid biosynthetic process154/8552252/187235.20e-076.96e-06154
GO:0072521111EsophagusESCCpurine-containing compound metabolic process238/8552416/187231.20e-061.49e-05238
GO:0009150111EsophagusESCCpurine ribonucleotide metabolic process213/8552368/187231.40e-061.69e-05213
GO:0006163111EsophagusESCCpurine nucleotide metabolic process226/8552396/187232.81e-063.21e-05226
GO:00060668EsophagusESCCalcohol metabolic process202/8552353/187237.32e-067.26e-05202
GO:00193958EsophagusESCCfatty acid oxidation69/8552103/187239.95e-069.44e-0569
GO:00060069EsophagusESCCglucose metabolic process119/8552196/187231.51e-051.36e-04119
GO:00421573EsophagusESCClipoprotein metabolic process86/8552135/187231.78e-051.57e-0486
GO:00344407EsophagusESCClipid oxidation71/8552108/187232.00e-051.74e-0471
GO:00066318EsophagusESCCfatty acid metabolic process217/8552390/187234.21e-053.39e-04217
GO:00199155EsophagusESCClipid storage58/855287/187236.15e-054.72e-0458
GO:00442626EsophagusESCCcellular carbohydrate metabolic process160/8552283/187231.43e-049.66e-04160
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa005615LiverHCCGlycerolipid metabolism41/402063/84653.59e-031.12e-026.22e-0341
hsa0056112LiverHCCGlycerolipid metabolism41/402063/84653.59e-031.12e-026.22e-0341
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DGAT2SNVMissense_Mutationrs139005829c.871G>Ap.Glu291Lysp.E291KQ96PD7protein_codingtolerated(0.53)benign(0.427)TCGA-B6-A0IK-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
DGAT2SNVMissense_Mutationc.280N>Gp.Ile94Valp.I94VQ96PD7protein_codingdeleterious(0.05)benign(0.026)TCGA-E2-A1LK-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownPD
DGAT2SNVMissense_Mutationnovelc.814G>Cp.Asp272Hisp.D272HQ96PD7protein_codingtolerated(0.48)probably_damaging(0.969)TCGA-DS-A1OB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
DGAT2SNVMissense_Mutationc.103N>Cp.Glu35Glnp.E35QQ96PD7protein_codingtolerated_low_confidence(0.63)benign(0.018)TCGA-EK-A2R8-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
DGAT2SNVMissense_Mutationrs201842357c.967N>Ap.Asp323Asnp.D323NQ96PD7protein_codingtolerated(1)benign(0)TCGA-AA-3655-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
DGAT2SNVMissense_Mutationc.438G>Tp.Lys146Asnp.K146NQ96PD7protein_codingdeleterious(0)probably_damaging(0.986)TCGA-AA-3977-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
DGAT2SNVMissense_Mutationrs140088423c.802N>Tp.Arg268Cysp.R268CQ96PD7protein_codingdeleterious(0)possibly_damaging(0.825)TCGA-AG-3892-01Colorectumrectum adenocarcinomaFemale<65I/IIUnknownUnknownSD
DGAT2insertionNonsense_Mutationnovelc.778_779insAGGGCTTTGTGAAGCTGGCCCTGCGTCATGGGTGAGTGCp.Gly270_Ala271insTerp.G270_A271ins*Q96PD7protein_codingTCGA-CM-6676-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
DGAT2SNVMissense_Mutationnovelc.491N>Tp.Gly164Valp.G164VQ96PD7protein_codingdeleterious(0)probably_damaging(1)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
DGAT2SNVMissense_Mutationnovelc.19N>Ap.Ala7Thrp.A7TQ96PD7protein_codingdeleterious_low_confidence(0)benign(0.318)TCGA-AJ-A3BG-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapycarboplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
84649DGAT2ENZYMEVitamin B3
84649DGAT2ENZYMEPMID25470667-Compound-roselipins
84649DGAT2ENZYMEPMID25470667-Compound-Figure4-1A
84649DGAT2ENZYMEARI-3037MO
84649DGAT2ENZYMEPF-06427878
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