![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DEXI |
Gene summary for DEXI |
![]() |
Gene information | Species | Human | Gene symbol | DEXI | Gene ID | 28955 |
Gene name | Dexi homolog | |
Gene Alias | MYLE | |
Cytomap | 16p13.13 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | O95424 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28955 | DEXI | LZE24T | Human | Esophagus | ESCC | 2.19e-07 | 1.09e-01 | 0.0596 |
28955 | DEXI | P1T-E | Human | Esophagus | ESCC | 7.93e-03 | 2.37e-01 | 0.0875 |
28955 | DEXI | P2T-E | Human | Esophagus | ESCC | 3.99e-52 | 8.33e-01 | 0.1177 |
28955 | DEXI | P4T-E | Human | Esophagus | ESCC | 9.89e-17 | 4.84e-01 | 0.1323 |
28955 | DEXI | P5T-E | Human | Esophagus | ESCC | 1.03e-14 | 1.82e-01 | 0.1327 |
28955 | DEXI | P8T-E | Human | Esophagus | ESCC | 1.61e-13 | 1.44e-01 | 0.0889 |
28955 | DEXI | P9T-E | Human | Esophagus | ESCC | 9.56e-12 | 1.65e-01 | 0.1131 |
28955 | DEXI | P10T-E | Human | Esophagus | ESCC | 2.67e-11 | 1.80e-01 | 0.116 |
28955 | DEXI | P11T-E | Human | Esophagus | ESCC | 4.97e-09 | 3.39e-01 | 0.1426 |
28955 | DEXI | P12T-E | Human | Esophagus | ESCC | 2.53e-18 | 2.89e-01 | 0.1122 |
28955 | DEXI | P15T-E | Human | Esophagus | ESCC | 2.00e-07 | 1.38e-01 | 0.1149 |
28955 | DEXI | P16T-E | Human | Esophagus | ESCC | 2.92e-14 | 2.27e-01 | 0.1153 |
28955 | DEXI | P19T-E | Human | Esophagus | ESCC | 3.30e-02 | 3.29e-01 | 0.1662 |
28955 | DEXI | P20T-E | Human | Esophagus | ESCC | 5.92e-13 | 1.51e-01 | 0.1124 |
28955 | DEXI | P21T-E | Human | Esophagus | ESCC | 4.31e-16 | 1.85e-01 | 0.1617 |
28955 | DEXI | P22T-E | Human | Esophagus | ESCC | 9.86e-24 | 3.62e-01 | 0.1236 |
28955 | DEXI | P23T-E | Human | Esophagus | ESCC | 5.74e-15 | 3.86e-01 | 0.108 |
28955 | DEXI | P24T-E | Human | Esophagus | ESCC | 2.07e-05 | 4.70e-02 | 0.1287 |
28955 | DEXI | P26T-E | Human | Esophagus | ESCC | 2.89e-21 | 3.49e-01 | 0.1276 |
28955 | DEXI | P27T-E | Human | Esophagus | ESCC | 4.81e-12 | 1.28e-01 | 0.1055 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEXI | SNV | Missense_Mutation | c.133N>G | p.Phe45Val | p.F45V | O95424 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-DM-A288-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
DEXI | SNV | Missense_Mutation | novel | c.259N>T | p.Leu87Phe | p.L87F | O95424 | protein_coding | tolerated_low_confidence(0.13) | possibly_damaging(0.744) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
DEXI | SNV | Missense_Mutation | novel | c.130N>A | p.Ala44Thr | p.A44T | O95424 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.722) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEXI | SNV | Missense_Mutation | c.68N>T | p.Pro23Leu | p.P23L | O95424 | protein_coding | tolerated_low_confidence(0.23) | benign(0) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |