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Gene: DEPDC7 |
Gene summary for DEPDC7 |
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Gene information | Species | Human | Gene symbol | DEPDC7 | Gene ID | 91614 |
Gene name | DEP domain containing 7 | |
Gene Alias | TR2 | |
Cytomap | 11p13 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q96QD5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91614 | DEPDC7 | NAFLD1 | Human | Liver | NAFLD | 5.35e-05 | 5.11e-01 | -0.04 |
91614 | DEPDC7 | S43 | Human | Liver | Cirrhotic | 4.78e-05 | -1.58e-01 | -0.0187 |
91614 | DEPDC7 | HCC1_Meng | Human | Liver | HCC | 7.72e-11 | -1.24e-01 | 0.0246 |
91614 | DEPDC7 | cirrhotic1 | Human | Liver | Cirrhotic | 1.17e-02 | -1.48e-01 | 0.0202 |
91614 | DEPDC7 | cirrhotic2 | Human | Liver | Cirrhotic | 2.78e-02 | -1.47e-01 | 0.0201 |
91614 | DEPDC7 | HCC1 | Human | Liver | HCC | 5.22e-03 | 2.42e+00 | 0.5336 |
91614 | DEPDC7 | Pt14.d | Human | Liver | HCC | 4.78e-05 | -1.43e-01 | 0.0143 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEPDC7 | SNV | Missense_Mutation | novel | c.1118A>C | p.Glu373Ala | p.E373A | Q96QD5 | protein_coding | tolerated(0.26) | possibly_damaging(0.877) | TCGA-AN-A03Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DEPDC7 | SNV | Missense_Mutation | novel | c.206N>T | p.Ser69Leu | p.S69L | Q96QD5 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC7 | SNV | Missense_Mutation | c.493N>A | p.Asp165Asn | p.D165N | Q96QD5 | protein_coding | tolerated(0.42) | benign(0.006) | TCGA-D8-A1JD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
DEPDC7 | SNV | Missense_Mutation | c.626N>A | p.Gly209Glu | p.G209E | Q96QD5 | protein_coding | tolerated(0.29) | benign(0.12) | TCGA-A6-5660-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
DEPDC7 | SNV | Missense_Mutation | c.1491C>A | p.Phe497Leu | p.F497L | Q96QD5 | protein_coding | deleterious(0.03) | probably_damaging(0.97) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DEPDC7 | SNV | Missense_Mutation | rs374445520 | c.1361G>T | p.Arg454Ile | p.R454I | Q96QD5 | protein_coding | deleterious(0) | possibly_damaging(0.641) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DEPDC7 | SNV | Missense_Mutation | c.886N>T | p.Asp296Tyr | p.D296Y | Q96QD5 | protein_coding | deleterious(0.01) | probably_damaging(0.921) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
DEPDC7 | SNV | Missense_Mutation | c.1491C>A | p.Phe497Leu | p.F497L | Q96QD5 | protein_coding | deleterious(0.03) | probably_damaging(0.97) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
DEPDC7 | SNV | Missense_Mutation | c.1195N>T | p.Asn399Tyr | p.N399Y | Q96QD5 | protein_coding | deleterious(0.03) | possibly_damaging(0.87) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD | |
DEPDC7 | insertion | Nonsense_Mutation | novel | c.576_577insTACCTAAAATGAATTTATTTC | p.Ala192_Thr193insTyrLeuLysTerIleTyrPhe | p.A192_T193insYLK*IYF | Q96QD5 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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