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Gene: DEPDC4 |
Gene summary for DEPDC4 |
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Gene information | Species | Human | Gene symbol | DEPDC4 | Gene ID | 120863 |
Gene name | DEP domain containing 4 | |
Gene Alias | DEP.4 | |
Cytomap | 12q23.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8N2C3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
120863 | DEPDC4 | HCC1_Meng | Human | Liver | HCC | 8.60e-14 | 6.05e-03 | 0.0246 |
120863 | DEPDC4 | HCC1 | Human | Liver | HCC | 1.18e-10 | 1.62e+00 | 0.5336 |
120863 | DEPDC4 | HCC2 | Human | Liver | HCC | 7.59e-18 | 2.33e+00 | 0.5341 |
120863 | DEPDC4 | HCC5 | Human | Liver | HCC | 7.79e-20 | 1.59e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEPDC4 | SNV | Missense_Mutation | c.431N>C | p.Lys144Thr | p.K144T | Q8N2C3 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
DEPDC4 | SNV | Missense_Mutation | c.31C>G | p.Leu11Val | p.L11V | Q8N2C3 | protein_coding | tolerated_low_confidence(0.14) | benign(0.001) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DEPDC4 | SNV | Missense_Mutation | c.4G>A | p.Val2Met | p.V2M | Q8N2C3 | protein_coding | deleterious_low_confidence(0) | benign(0.094) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DEPDC4 | SNV | Missense_Mutation | c.125N>C | p.Arg42Pro | p.R42P | Q8N2C3 | protein_coding | tolerated(0.54) | benign(0) | TCGA-D8-A142-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamid | SD | |
DEPDC4 | SNV | Missense_Mutation | c.226N>C | p.Glu76Gln | p.E76Q | Q8N2C3 | protein_coding | deleterious(0) | possibly_damaging(0.686) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DEPDC4 | SNV | Missense_Mutation | c.820N>G | p.Leu274Val | p.L274V | Q8N2C3 | protein_coding | tolerated(0.07) | benign(0.147) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
DEPDC4 | SNV | Missense_Mutation | c.828N>G | p.Ile276Met | p.I276M | Q8N2C3 | protein_coding | deleterious(0.01) | benign(0.378) | TCGA-C5-A1BJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DEPDC4 | SNV | Missense_Mutation | novel | c.236G>C | p.Arg79Thr | p.R79T | Q8N2C3 | protein_coding | deleterious(0.01) | possibly_damaging(0.533) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DEPDC4 | SNV | Missense_Mutation | novel | c.641N>T | p.Asn214Ile | p.N214I | Q8N2C3 | protein_coding | deleterious(0.03) | benign(0.395) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DEPDC4 | SNV | Missense_Mutation | c.682N>A | p.Leu228Ile | p.L228I | Q8N2C3 | protein_coding | tolerated(0.39) | benign(0.053) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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