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Gene: DENND4B |
Gene summary for DENND4B |
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Gene information | Species | Human | Gene symbol | DENND4B | Gene ID | 9909 |
Gene name | DENN domain containing 4B | |
Gene Alias | KIAA0476 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O75064 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9909 | DENND4B | HCC1_Meng | Human | Liver | HCC | 1.04e-16 | 2.19e-02 | 0.0246 |
9909 | DENND4B | HCC1 | Human | Liver | HCC | 4.22e-04 | 2.41e+00 | 0.5336 |
9909 | DENND4B | HCC2 | Human | Liver | HCC | 8.13e-12 | 2.30e+00 | 0.5341 |
9909 | DENND4B | S016 | Human | Liver | HCC | 2.85e-06 | 2.42e-01 | 0.2243 |
9909 | DENND4B | S028 | Human | Liver | HCC | 1.68e-04 | 2.61e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:004657811 | Liver | HCC | regulation of Ras protein signal transduction | 100/7958 | 189/18723 | 2.42e-03 | 1.18e-02 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DENND4B | SNV | Missense_Mutation | novel | c.935N>G | p.Val312Gly | p.V312G | O75064 | protein_coding | deleterious(0) | benign(0.433) | TCGA-A2-A0T7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DENND4B | SNV | Missense_Mutation | c.2033N>G | p.Glu678Gly | p.E678G | O75064 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DENND4B | SNV | Missense_Mutation | rs748707602 | c.2903G>A | p.Arg968Gln | p.R968Q | O75064 | protein_coding | tolerated(0.08) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DENND4B | SNV | Missense_Mutation | rs763426290 | c.991C>T | p.Arg331Cys | p.R331C | O75064 | protein_coding | deleterious(0) | possibly_damaging(0.568) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DENND4B | SNV | Missense_Mutation | novel | c.935N>G | p.Val312Gly | p.V312G | O75064 | protein_coding | deleterious(0) | benign(0.433) | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
DENND4B | SNV | Missense_Mutation | c.1802N>G | p.Asn601Ser | p.N601S | O75064 | protein_coding | tolerated(1) | benign(0.018) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
DENND4B | SNV | Missense_Mutation | c.947N>C | p.Arg316Pro | p.R316P | O75064 | protein_coding | deleterious(0) | possibly_damaging(0.664) | TCGA-BH-A0DD-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR | |
DENND4B | SNV | Missense_Mutation | c.3563N>T | p.Pro1188Leu | p.P1188L | O75064 | protein_coding | deleterious(0) | benign(0.063) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
DENND4B | SNV | Missense_Mutation | c.946C>T | p.Arg316Cys | p.R316C | O75064 | protein_coding | deleterious(0) | possibly_damaging(0.848) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
DENND4B | SNV | Missense_Mutation | c.2867N>A | p.Gly956Glu | p.G956E | O75064 | protein_coding | tolerated(0.09) | probably_damaging(0.998) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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