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Gene: DENND11 |
Gene summary for DENND11 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DENND11 | Gene ID | 57189 |
| Gene name | DENN domain containing 11 | |
| Gene Alias | KIAA1147 | |
| Cytomap | 7q34 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A4D1U4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57189 | DENND11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.87e-02 | 1.07e-01 | -0.1808 |
| 57189 | DENND11 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.73e-09 | 2.98e-01 | -0.0811 |
| 57189 | DENND11 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.71e-23 | 5.39e-01 | -0.1088 |
| 57189 | DENND11 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.88e-15 | 3.36e-01 | -0.1954 |
| 57189 | DENND11 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.07e-04 | 1.23e-01 | -0.1464 |
| 57189 | DENND11 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-08 | 1.81e-01 | -0.1001 |
| 57189 | DENND11 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.02e-09 | 2.19e-01 | -0.059 |
| 57189 | DENND11 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-06 | 2.45e-01 | -0.0842 |
| 57189 | DENND11 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.21e-02 | 3.00e-01 | 0.0171 |
| 57189 | DENND11 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.67e-03 | 1.44e-01 | 0.0338 |
| 57189 | DENND11 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.07e-07 | 1.74e-01 | 0.0674 |
| 57189 | DENND11 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.25e-06 | 3.09e-01 | 0.0112 |
| 57189 | DENND11 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.54e-06 | 2.30e-01 | 0.0588 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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