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Gene: DENND10 |
Gene summary for DENND10 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DENND10 | Gene ID | 404636 |
| Gene name | DENN domain containing 10 | |
| Gene Alias | FAM45A | |
| Cytomap | 10q26.11 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8TCE6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 404636 | DENND10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.47e-03 | 1.13e-01 | 0.0155 |
| 404636 | DENND10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.68e-08 | 2.32e-01 | -0.1808 |
| 404636 | DENND10 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 3.08e-01 | 0.0216 |
| 404636 | DENND10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.58e-13 | 4.80e-01 | -0.0811 |
| 404636 | DENND10 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.40e-18 | 4.55e-01 | -0.1088 |
| 404636 | DENND10 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.17e-24 | 4.68e-01 | -0.1954 |
| 404636 | DENND10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.49e-10 | 3.50e-01 | -0.1207 |
| 404636 | DENND10 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.13e-10 | 3.59e-01 | -0.1526 |
| 404636 | DENND10 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.55e-09 | 2.09e-01 | -0.1464 |
| 404636 | DENND10 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-08 | 1.89e-01 | -0.1001 |
| 404636 | DENND10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.01e-20 | 4.63e-01 | -0.059 |
| 404636 | DENND10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-02 | 1.93e-01 | -0.2061 |
| 404636 | DENND10 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.71e-06 | 2.75e-01 | -0.0842 |
| 404636 | DENND10 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.79e-05 | 2.88e-01 | -0.0179 |
| 404636 | DENND10 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.04e-08 | 2.17e-01 | 0.096 |
| 404636 | DENND10 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.30e-17 | 6.86e-01 | 0.0131 |
| 404636 | DENND10 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.04e-05 | 2.63e-01 | -0.0177 |
| 404636 | DENND10 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.31e-12 | 6.45e-01 | 0.0171 |
| 404636 | DENND10 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.64e-06 | 2.02e-01 | 0.0338 |
| 404636 | DENND10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.08e-11 | 2.44e-01 | 0.0674 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
| GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
| GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
| GO:0071985 | Colorectum | AD | multivesicular body sorting pathway | 19/3918 | 37/18723 | 4.08e-05 | 7.26e-04 | 19 |
| GO:0032509 | Colorectum | AD | endosome transport via multivesicular body sorting pathway | 16/3918 | 31/18723 | 1.53e-04 | 2.16e-03 | 16 |
| GO:0098927 | Colorectum | AD | vesicle-mediated transport between endosomal compartments | 19/3918 | 43/18723 | 5.03e-04 | 5.43e-03 | 19 |
| GO:0045022 | Colorectum | AD | early endosome to late endosome transport | 17/3918 | 40/18723 | 1.66e-03 | 1.38e-02 | 17 |
| GO:1903649 | Colorectum | AD | regulation of cytoplasmic transport | 13/3918 | 28/18723 | 2.22e-03 | 1.75e-02 | 13 |
| GO:00323861 | Colorectum | SER | regulation of intracellular transport | 89/2897 | 337/18723 | 1.34e-07 | 7.96e-06 | 89 |
| GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
| GO:00719851 | Colorectum | SER | multivesicular body sorting pathway | 17/2897 | 37/18723 | 1.12e-05 | 3.60e-04 | 17 |
| GO:00325091 | Colorectum | SER | endosome transport via multivesicular body sorting pathway | 15/2897 | 31/18723 | 1.70e-05 | 5.11e-04 | 15 |
| GO:00164821 | Colorectum | SER | cytosolic transport | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
| GO:00989271 | Colorectum | SER | vesicle-mediated transport between endosomal compartments | 16/2897 | 43/18723 | 4.18e-04 | 6.17e-03 | 16 |
| GO:00450221 | Colorectum | SER | early endosome to late endosome transport | 14/2897 | 40/18723 | 1.88e-03 | 1.90e-02 | 14 |
| GO:19036491 | Colorectum | SER | regulation of cytoplasmic transport | 11/2897 | 28/18723 | 1.98e-03 | 1.98e-02 | 11 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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