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Gene: DECR1 |
Gene summary for DECR1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DECR1 | Gene ID | 1666 |
| Gene name | 2,4-dienoyl-CoA reductase 1 | |
| Gene Alias | DECR | |
| Cytomap | 8q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q16698 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1666 | DECR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.91e-11 | 5.55e-01 | -0.1954 |
| 1666 | DECR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.48e-03 | 4.84e-01 | 0.281 |
| 1666 | DECR1 | A001-C-207 | Human | Colorectum | FAP | 2.55e-02 | -1.54e-01 | 0.1278 |
| 1666 | DECR1 | A015-C-203 | Human | Colorectum | FAP | 2.31e-16 | -3.69e-01 | -0.1294 |
| 1666 | DECR1 | A015-C-204 | Human | Colorectum | FAP | 9.07e-05 | -2.14e-01 | -0.0228 |
| 1666 | DECR1 | A014-C-040 | Human | Colorectum | FAP | 1.85e-02 | -3.70e-01 | -0.1184 |
| 1666 | DECR1 | A002-C-201 | Human | Colorectum | FAP | 2.23e-07 | -2.44e-01 | 0.0324 |
| 1666 | DECR1 | A002-C-203 | Human | Colorectum | FAP | 1.33e-03 | -2.32e-01 | 0.2786 |
| 1666 | DECR1 | A001-C-119 | Human | Colorectum | FAP | 4.18e-05 | -4.02e-01 | -0.1557 |
| 1666 | DECR1 | A001-C-108 | Human | Colorectum | FAP | 1.29e-08 | -2.57e-01 | -0.0272 |
| 1666 | DECR1 | A002-C-205 | Human | Colorectum | FAP | 3.74e-15 | -3.54e-01 | -0.1236 |
| 1666 | DECR1 | A015-C-005 | Human | Colorectum | FAP | 1.89e-03 | -2.55e-01 | -0.0336 |
| 1666 | DECR1 | A015-C-006 | Human | Colorectum | FAP | 9.84e-11 | -3.13e-01 | -0.0994 |
| 1666 | DECR1 | A015-C-106 | Human | Colorectum | FAP | 1.33e-07 | -3.28e-01 | -0.0511 |
| 1666 | DECR1 | A002-C-114 | Human | Colorectum | FAP | 1.91e-12 | -3.34e-01 | -0.1561 |
| 1666 | DECR1 | A015-C-104 | Human | Colorectum | FAP | 8.49e-15 | -3.22e-01 | -0.1899 |
| 1666 | DECR1 | A001-C-014 | Human | Colorectum | FAP | 1.36e-05 | -1.96e-01 | 0.0135 |
| 1666 | DECR1 | A002-C-016 | Human | Colorectum | FAP | 4.84e-08 | -2.39e-01 | 0.0521 |
| 1666 | DECR1 | A015-C-002 | Human | Colorectum | FAP | 1.34e-06 | -3.06e-01 | -0.0763 |
| 1666 | DECR1 | A002-C-116 | Human | Colorectum | FAP | 5.34e-19 | -3.73e-01 | -0.0452 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
| GO:0006635 | Colorectum | AD | fatty acid beta-oxidation | 33/3918 | 74/18723 | 3.98e-06 | 1.09e-04 | 33 |
| GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
| GO:0019395 | Colorectum | AD | fatty acid oxidation | 40/3918 | 103/18723 | 2.43e-05 | 4.69e-04 | 40 |
| GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
| GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
| GO:0072329 | Colorectum | AD | monocarboxylic acid catabolic process | 44/3918 | 122/18723 | 8.05e-05 | 1.28e-03 | 44 |
| GO:0034440 | Colorectum | AD | lipid oxidation | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
| GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
| GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
| GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
| GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
| GO:0120162 | Colorectum | AD | positive regulation of cold-induced thermogenesis | 32/3918 | 97/18723 | 3.74e-03 | 2.63e-02 | 32 |
| GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
| GO:0120161 | Colorectum | AD | regulation of cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
| GO:1990845 | Colorectum | AD | adaptive thermogenesis | 46/3918 | 157/18723 | 7.97e-03 | 4.73e-02 | 46 |
| GO:00090622 | Colorectum | MSS | fatty acid catabolic process | 32/3467 | 100/18723 | 8.28e-04 | 8.67e-03 | 32 |
| GO:00442822 | Colorectum | MSS | small molecule catabolic process | 94/3467 | 376/18723 | 9.85e-04 | 9.86e-03 | 94 |
| GO:00302582 | Colorectum | MSS | lipid modification | 57/3467 | 212/18723 | 1.64e-03 | 1.49e-02 | 57 |
| GO:00066312 | Colorectum | MSS | fatty acid metabolic process | 95/3467 | 390/18723 | 2.20e-03 | 1.84e-02 | 95 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DECR1 | SNV | Missense_Mutation | c.129N>G | p.Phe43Leu | p.F43L | Q16698 | protein_coding | deleterious(0.04) | benign(0.01) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| DECR1 | SNV | Missense_Mutation | novel | c.171N>G | p.Phe57Leu | p.F57L | Q16698 | protein_coding | tolerated(0.73) | benign(0.021) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| DECR1 | SNV | Missense_Mutation | c.272N>C | p.Arg91Pro | p.R91P | Q16698 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| DECR1 | SNV | Missense_Mutation | c.470C>T | p.Ser157Phe | p.S157F | Q16698 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DECR1 | SNV | Missense_Mutation | c.737N>C | p.Lys246Thr | p.K246T | Q16698 | protein_coding | deleterious(0.01) | benign(0.224) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD | |
| DECR1 | SNV | Missense_Mutation | novel | c.776N>C | p.Glu259Ala | p.E259A | Q16698 | protein_coding | tolerated(0.07) | benign(0.043) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| DECR1 | SNV | Missense_Mutation | rs781613500 | c.53G>T | p.Gly18Val | p.G18V | Q16698 | protein_coding | tolerated_low_confidence(0.4) | benign(0) | TCGA-D5-6534-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| DECR1 | SNV | Missense_Mutation | c.205N>G | p.Thr69Ala | p.T69A | Q16698 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-D5-6929-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+ | SD | |
| DECR1 | SNV | Missense_Mutation | novel | c.944N>T | p.Arg315Ile | p.R315I | Q16698 | protein_coding | tolerated(0.07) | benign(0.017) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| DECR1 | SNV | Missense_Mutation | novel | c.568N>A | p.Ala190Thr | p.A190T | Q16698 | protein_coding | tolerated(0.07) | possibly_damaging(0.554) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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