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Gene: DDX52 |
Gene summary for DDX52 |
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Gene information | Species | Human | Gene symbol | DDX52 | Gene ID | 11056 |
Gene name | DExD-box helicase 52 | |
Gene Alias | HUSSY19 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KM65 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11056 | DDX52 | LZE4T | Human | Esophagus | ESCC | 2.19e-08 | 2.52e-01 | 0.0811 |
11056 | DDX52 | LZE5T | Human | Esophagus | ESCC | 1.26e-05 | 4.45e-01 | 0.0514 |
11056 | DDX52 | LZE7T | Human | Esophagus | ESCC | 2.24e-07 | 5.40e-01 | 0.0667 |
11056 | DDX52 | LZE22T | Human | Esophagus | ESCC | 4.04e-03 | 1.87e-01 | 0.068 |
11056 | DDX52 | LZE24T | Human | Esophagus | ESCC | 3.63e-13 | 3.97e-01 | 0.0596 |
11056 | DDX52 | LZE21T | Human | Esophagus | ESCC | 2.82e-06 | 2.94e-01 | 0.0655 |
11056 | DDX52 | LZE6T | Human | Esophagus | ESCC | 2.38e-02 | 1.73e-01 | 0.0845 |
11056 | DDX52 | P1T-E | Human | Esophagus | ESCC | 1.86e-14 | 4.02e-01 | 0.0875 |
11056 | DDX52 | P2T-E | Human | Esophagus | ESCC | 1.52e-17 | 3.49e-01 | 0.1177 |
11056 | DDX52 | P4T-E | Human | Esophagus | ESCC | 6.88e-29 | 6.93e-01 | 0.1323 |
11056 | DDX52 | P5T-E | Human | Esophagus | ESCC | 4.25e-09 | 2.32e-01 | 0.1327 |
11056 | DDX52 | P8T-E | Human | Esophagus | ESCC | 3.23e-21 | 4.85e-01 | 0.0889 |
11056 | DDX52 | P9T-E | Human | Esophagus | ESCC | 1.17e-16 | 2.39e-01 | 0.1131 |
11056 | DDX52 | P10T-E | Human | Esophagus | ESCC | 1.21e-12 | 2.02e-01 | 0.116 |
11056 | DDX52 | P11T-E | Human | Esophagus | ESCC | 2.14e-08 | 4.22e-01 | 0.1426 |
11056 | DDX52 | P12T-E | Human | Esophagus | ESCC | 3.16e-21 | 4.65e-01 | 0.1122 |
11056 | DDX52 | P15T-E | Human | Esophagus | ESCC | 3.22e-21 | 4.38e-01 | 0.1149 |
11056 | DDX52 | P16T-E | Human | Esophagus | ESCC | 1.37e-17 | 3.25e-01 | 0.1153 |
11056 | DDX52 | P17T-E | Human | Esophagus | ESCC | 2.97e-02 | 2.94e-01 | 0.1278 |
11056 | DDX52 | P19T-E | Human | Esophagus | ESCC | 2.79e-08 | 4.79e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:004227422 | Liver | HCC | ribosomal small subunit biogenesis | 65/7958 | 73/18723 | 1.09e-16 | 9.92e-15 | 65 |
GO:00304901 | Liver | HCC | maturation of SSU-rRNA | 43/7958 | 50/18723 | 2.35e-10 | 8.04e-09 | 43 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX52 | SNV | Missense_Mutation | novel | c.766N>C | p.Lys256Gln | p.K256Q | Q9Y2R4 | protein_coding | tolerated(0.17) | benign(0.015) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX52 | SNV | Missense_Mutation | rs758093058 | c.1307N>T | p.Gly436Val | p.G436V | Q9Y2R4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-GM-A2DC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
DDX52 | SNV | Missense_Mutation | novel | c.1021G>A | p.Ala341Thr | p.A341T | Q9Y2R4 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
DDX52 | SNV | Missense_Mutation | novel | c.252N>C | p.Glu84Asp | p.E84D | Q9Y2R4 | protein_coding | tolerated(0.21) | benign(0.038) | TCGA-FU-A5XV-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
DDX52 | SNV | Missense_Mutation | novel | c.1667N>C | p.Met556Thr | p.M556T | Q9Y2R4 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DDX52 | SNV | Missense_Mutation | novel | c.446T>C | p.Ile149Thr | p.I149T | Q9Y2R4 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DDX52 | SNV | Missense_Mutation | novel | c.665C>A | p.Pro222His | p.P222H | Q9Y2R4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX52 | SNV | Missense_Mutation | novel | c.1417N>A | p.Ala473Thr | p.A473T | Q9Y2R4 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX52 | SNV | Missense_Mutation | novel | c.1167G>T | p.Glu389Asp | p.E389D | Q9Y2R4 | protein_coding | deleterious(0.03) | benign(0.098) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
DDX52 | SNV | Missense_Mutation | novel | c.463N>A | p.Asp155Asn | p.D155N | Q9Y2R4 | protein_coding | tolerated(0.14) | benign(0.189) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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