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Gene: DDX51 |
Gene summary for DDX51 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DDX51 | Gene ID | 317781 |
Gene name | DEAD-box helicase 51 | |
Gene Alias | DDX51 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N8A6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
317781 | DDX51 | HCC1_Meng | Human | Liver | HCC | 3.05e-23 | -9.10e-03 | 0.0246 |
317781 | DDX51 | HCC2_Meng | Human | Liver | HCC | 1.91e-04 | 1.28e-02 | 0.0107 |
317781 | DDX51 | HCC1 | Human | Liver | HCC | 7.30e-25 | 3.56e+00 | 0.5336 |
317781 | DDX51 | HCC2 | Human | Liver | HCC | 3.88e-34 | 3.15e+00 | 0.5341 |
317781 | DDX51 | HCC5 | Human | Liver | HCC | 4.95e-34 | 2.04e+00 | 0.4932 |
317781 | DDX51 | S027 | Human | Liver | HCC | 4.75e-05 | 5.04e-01 | 0.2446 |
317781 | DDX51 | S028 | Human | Liver | HCC | 2.21e-06 | 3.78e-01 | 0.2503 |
317781 | DDX51 | S029 | Human | Liver | HCC | 1.18e-05 | 3.55e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX51 | SNV | Missense_Mutation | rs779618653 | c.1246N>A | p.Ala416Thr | p.A416T | Q8N8A6 | protein_coding | deleterious(0.01) | benign(0.421) | TCGA-LL-A5YM-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unspecific | letrozole | PD |
DDX51 | deletion | Frame_Shift_Del | novel | c.1568delN | p.Leu523ArgfsTer24 | p.L523Rfs*24 | Q8N8A6 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
DDX51 | SNV | Missense_Mutation | rs372686080 | c.1174N>A | p.Ala392Thr | p.A392T | Q8N8A6 | protein_coding | tolerated(0.1) | benign(0.107) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DDX51 | SNV | Missense_Mutation | c.1420N>A | p.Ala474Thr | p.A474T | Q8N8A6 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
DDX51 | SNV | Missense_Mutation | novel | c.1652N>G | p.Phe551Cys | p.F551C | Q8N8A6 | protein_coding | deleterious(0) | possibly_damaging(0.86) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
DDX51 | SNV | Missense_Mutation | c.869N>T | p.Thr290Ile | p.T290I | Q8N8A6 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DDX51 | SNV | Missense_Mutation | rs780089893 | c.1697N>T | p.Ala566Val | p.A566V | Q8N8A6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
DDX51 | SNV | Missense_Mutation | c.1796C>T | p.Ala599Val | p.A599V | Q8N8A6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DDX51 | insertion | Frame_Shift_Ins | novel | c.1750_1751insC | p.Gln584ProfsTer40 | p.Q584Pfs*40 | Q8N8A6 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
DDX51 | SNV | Missense_Mutation | rs767583936 | c.1402G>A | p.Gly468Arg | p.G468R | Q8N8A6 | protein_coding | tolerated(0.37) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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