![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DDX43 |
Gene summary for DDX43 |
![]() |
Gene information | Species | Human | Gene symbol | DDX43 | Gene ID | 55510 |
Gene name | DEAD-box helicase 43 | |
Gene Alias | CT13 | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0000166 | UniProtAcc | Q9NXZ2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55510 | DDX43 | ATC13 | Human | Thyroid | ATC | 5.07e-25 | 4.84e-01 | 0.34 |
55510 | DDX43 | ATC2 | Human | Thyroid | ATC | 1.80e-12 | 7.13e-01 | 0.34 |
55510 | DDX43 | ATC5 | Human | Thyroid | ATC | 1.70e-34 | 5.34e-01 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX43 | SNV | Missense_Mutation | novel | c.866N>A | p.Gly289Glu | p.G289E | Q9NXZ2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
DDX43 | SNV | Missense_Mutation | c.648N>C | p.Trp216Cys | p.W216C | Q9NXZ2 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
DDX43 | SNV | Missense_Mutation | novel | c.1145N>T | p.Ser382Ile | p.S382I | Q9NXZ2 | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
DDX43 | SNV | Missense_Mutation | c.87N>T | p.Arg29Ser | p.R29S | Q9NXZ2 | protein_coding | deleterious_low_confidence(0.03) | benign(0.026) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DDX43 | SNV | Missense_Mutation | c.1918N>T | p.Pro640Ser | p.P640S | Q9NXZ2 | protein_coding | tolerated(0.27) | benign(0.013) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
DDX43 | SNV | Missense_Mutation | c.95N>T | p.Ala32Val | p.A32V | Q9NXZ2 | protein_coding | deleterious_low_confidence(0.03) | benign(0.122) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DDX43 | SNV | Missense_Mutation | novel | c.77N>G | p.Ala26Gly | p.A26G | Q9NXZ2 | protein_coding | tolerated_low_confidence(0.11) | benign(0.005) | TCGA-EW-A6SB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX43 | insertion | Frame_Shift_Ins | novel | c.1015_1016insCTGAA | p.Tyr339SerfsTer23 | p.Y339Sfs*23 | Q9NXZ2 | protein_coding | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
DDX43 | insertion | Frame_Shift_Ins | novel | c.1017_1018insTGGAAGGTTTTAATTGCAATGGTTTTTC | p.Ser340TrpfsTer12 | p.S340Wfs*12 | Q9NXZ2 | protein_coding | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
DDX43 | insertion | Nonsense_Mutation | novel | c.1147_1148insAAATATGAT | p.Asn383delinsLysIleTerTyr | p.N383delinsKI*Y | Q9NXZ2 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55510 | DDX43 | DRUG RESISTANCE | MEK INHIBITOR PD0325901 | 24899684 | ||
55510 | DDX43 | DRUG RESISTANCE | TRAMETINIB | TRAMETINIB | 24899684 | |
55510 | DDX43 | DRUG RESISTANCE | SELUMETINIB | SELUMETINIB | 24899684 |
Page: 1 |