![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DDX42 |
Gene summary for DDX42 |
![]() |
Gene information | Species | Human | Gene symbol | DDX42 | Gene ID | 11325 |
Gene name | DEAD-box helicase 42 | |
Gene Alias | DDX42P | |
Cytomap | 17q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q86XP3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11325 | DDX42 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.70e-02 | 3.36e-01 | -0.1954 |
11325 | DDX42 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.68e-04 | 5.30e-01 | 0.3859 |
11325 | DDX42 | A015-C-203 | Human | Colorectum | FAP | 7.50e-16 | 2.86e-02 | -0.1294 |
11325 | DDX42 | A002-C-201 | Human | Colorectum | FAP | 4.17e-06 | 5.44e-02 | 0.0324 |
11325 | DDX42 | A001-C-119 | Human | Colorectum | FAP | 7.64e-04 | 3.25e-01 | -0.1557 |
11325 | DDX42 | A001-C-108 | Human | Colorectum | FAP | 1.52e-08 | 1.42e-01 | -0.0272 |
11325 | DDX42 | A002-C-205 | Human | Colorectum | FAP | 5.61e-12 | 1.58e-01 | -0.1236 |
11325 | DDX42 | A001-C-104 | Human | Colorectum | FAP | 3.07e-02 | 2.36e-01 | 0.0184 |
11325 | DDX42 | A015-C-006 | Human | Colorectum | FAP | 6.52e-08 | 1.48e-01 | -0.0994 |
11325 | DDX42 | A015-C-106 | Human | Colorectum | FAP | 1.58e-04 | 7.41e-02 | -0.0511 |
11325 | DDX42 | A002-C-114 | Human | Colorectum | FAP | 1.05e-09 | 5.76e-02 | -0.1561 |
11325 | DDX42 | A015-C-104 | Human | Colorectum | FAP | 2.18e-18 | 7.65e-02 | -0.1899 |
11325 | DDX42 | A001-C-014 | Human | Colorectum | FAP | 3.77e-03 | 5.94e-02 | 0.0135 |
11325 | DDX42 | A002-C-016 | Human | Colorectum | FAP | 3.97e-08 | -3.73e-02 | 0.0521 |
11325 | DDX42 | A015-C-002 | Human | Colorectum | FAP | 1.11e-04 | 2.13e-02 | -0.0763 |
11325 | DDX42 | A001-C-203 | Human | Colorectum | FAP | 9.98e-05 | 1.19e-01 | -0.0481 |
11325 | DDX42 | A002-C-116 | Human | Colorectum | FAP | 1.54e-16 | -6.63e-02 | -0.0452 |
11325 | DDX42 | A014-C-008 | Human | Colorectum | FAP | 1.37e-08 | 1.89e-01 | -0.191 |
11325 | DDX42 | A018-E-020 | Human | Colorectum | FAP | 3.57e-11 | 2.01e-01 | -0.2034 |
11325 | DDX42 | F034 | Human | Colorectum | FAP | 4.94e-09 | 9.14e-02 | -0.0665 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304025 | Prostate | Tumor | Spliceosome | 66/1791 | 217/8465 | 7.53e-04 | 3.59e-03 | 2.23e-03 | 66 |
hsa0304035 | Prostate | Tumor | Spliceosome | 66/1791 | 217/8465 | 7.53e-04 | 3.59e-03 | 2.23e-03 | 66 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX42 | SNV | Missense_Mutation | novel | c.793N>G | p.Met265Val | p.M265V | Q86XP3 | protein_coding | deleterious(0.01) | benign(0.164) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
DDX42 | SNV | Missense_Mutation | c.485N>T | p.Arg162Leu | p.R162L | Q86XP3 | protein_coding | deleterious(0.01) | possibly_damaging(0.817) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
DDX42 | SNV | Missense_Mutation | c.1777N>A | p.Gly593Ser | p.G593S | Q86XP3 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DDX42 | SNV | Missense_Mutation | rs375864832 | c.2479C>T | p.Arg827Trp | p.R827W | Q86XP3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.985) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX42 | SNV | Missense_Mutation | rs542105191 | c.2675N>A | p.Arg892His | p.R892H | Q86XP3 | protein_coding | tolerated_low_confidence(0.07) | benign(0.06) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX42 | SNV | Missense_Mutation | c.454G>A | p.Glu152Lys | p.E152K | Q86XP3 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DDX42 | SNV | Missense_Mutation | rs137904708 | c.1067N>A | p.Arg356Gln | p.R356Q | Q86XP3 | protein_coding | tolerated(0.06) | benign(0.145) | TCGA-E2-A14T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
DDX42 | deletion | Frame_Shift_Del | c.910delA | p.Thr304LeufsTer9 | p.T304Lfs*9 | Q86XP3 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
DDX42 | SNV | Missense_Mutation | c.1332N>C | p.Lys444Asn | p.K444N | Q86XP3 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DDX42 | deletion | In_Frame_Del | novel | c.1056_1067delNNNNNNNNNNNN | p.Tyr353_Arg356del | p.Y353_R356del | Q86XP3 | protein_coding | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |