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Gene: DDX10 |
Gene summary for DDX10 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DDX10 | Gene ID | 1662 |
| Gene name | DEAD-box helicase 10 | |
| Gene Alias | Dbp4 | |
| Cytomap | 11q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q13206 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1662 | DDX10 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.13e-02 | -2.86e-01 | -0.1464 |
| 1662 | DDX10 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.02e-10 | -3.63e-01 | -0.1001 |
| 1662 | DDX10 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.37e-02 | -4.10e-01 | -0.0842 |
| 1662 | DDX10 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.14e-05 | -4.40e-01 | 0.096 |
| 1662 | DDX10 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.22e-02 | -4.39e-01 | 0.0338 |
| 1662 | DDX10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.94e-06 | -3.52e-01 | 0.0674 |
| 1662 | DDX10 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.21e-13 | -4.56e-01 | 0.3005 |
| 1662 | DDX10 | A001-C-207 | Human | Colorectum | FAP | 7.39e-03 | -2.30e-01 | 0.1278 |
| 1662 | DDX10 | A015-C-203 | Human | Colorectum | FAP | 4.36e-29 | -4.30e-01 | -0.1294 |
| 1662 | DDX10 | A015-C-204 | Human | Colorectum | FAP | 2.72e-04 | -2.38e-01 | -0.0228 |
| 1662 | DDX10 | A014-C-040 | Human | Colorectum | FAP | 7.64e-05 | -5.04e-01 | -0.1184 |
| 1662 | DDX10 | A002-C-201 | Human | Colorectum | FAP | 1.03e-12 | -3.67e-01 | 0.0324 |
| 1662 | DDX10 | A001-C-119 | Human | Colorectum | FAP | 5.79e-07 | -3.83e-01 | -0.1557 |
| 1662 | DDX10 | A001-C-108 | Human | Colorectum | FAP | 1.11e-18 | -3.24e-01 | -0.0272 |
| 1662 | DDX10 | A002-C-205 | Human | Colorectum | FAP | 7.12e-17 | -2.31e-01 | -0.1236 |
| 1662 | DDX10 | A001-C-104 | Human | Colorectum | FAP | 1.18e-03 | -2.28e-01 | 0.0184 |
| 1662 | DDX10 | A015-C-005 | Human | Colorectum | FAP | 2.86e-04 | -2.86e-01 | -0.0336 |
| 1662 | DDX10 | A015-C-006 | Human | Colorectum | FAP | 4.78e-11 | -1.67e-01 | -0.0994 |
| 1662 | DDX10 | A015-C-106 | Human | Colorectum | FAP | 2.73e-12 | -2.09e-01 | -0.0511 |
| 1662 | DDX10 | A002-C-114 | Human | Colorectum | FAP | 2.85e-15 | -3.65e-01 | -0.1561 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
| GO:0042254 | Colorectum | AD | ribosome biogenesis | 84/3918 | 299/18723 | 1.82e-03 | 1.50e-02 | 84 |
| GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
| GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
| GO:0006364 | Colorectum | MSS | rRNA processing | 58/3467 | 225/18723 | 4.17e-03 | 3.03e-02 | 58 |
| GO:0016072 | Colorectum | MSS | rRNA metabolic process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
| GO:00226134 | Colorectum | FAP | ribonucleoprotein complex biogenesis | 91/2622 | 463/18723 | 4.28e-04 | 5.12e-03 | 91 |
| GO:00226135 | Colorectum | CRC | ribonucleoprotein complex biogenesis | 76/2078 | 463/18723 | 3.04e-04 | 4.78e-03 | 76 |
| GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
| GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
| GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
| GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
| GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
| GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
| GO:00226137 | Liver | NAFLD | ribonucleoprotein complex biogenesis | 76/1882 | 463/18723 | 1.19e-05 | 3.67e-04 | 76 |
| GO:00422547 | Liver | NAFLD | ribosome biogenesis | 52/1882 | 299/18723 | 6.03e-05 | 1.32e-03 | 52 |
| GO:00344704 | Liver | NAFLD | ncRNA processing | 57/1882 | 395/18723 | 3.34e-03 | 2.93e-02 | 57 |
| GO:00063644 | Liver | NAFLD | rRNA processing | 35/1882 | 225/18723 | 6.04e-03 | 4.54e-02 | 35 |
| GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
| GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DDX10 | SNV | Missense_Mutation | novel | c.1960N>G | p.Leu654Val | p.L654V | Q13206 | protein_coding | tolerated(0.21) | benign(0.162) | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
| DDX10 | SNV | Missense_Mutation | novel | c.1421C>G | p.Ser474Cys | p.S474C | Q13206 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| DDX10 | SNV | Missense_Mutation | novel | c.364N>A | p.Ala122Thr | p.A122T | Q13206 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| DDX10 | SNV | Missense_Mutation | novel | c.1656N>A | p.Phe552Leu | p.F552L | Q13206 | protein_coding | tolerated(0.28) | benign(0) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| DDX10 | SNV | Missense_Mutation | novel | c.44N>G | p.Asp15Gly | p.D15G | Q13206 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.612) | TCGA-OL-A97C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| DDX10 | insertion | In_Frame_Ins | novel | c.1961_1962insCATCTCAAC | p.Leu654delinsPheIleSerThr | p.L654delinsFIST | Q13206 | protein_coding | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| DDX10 | SNV | Missense_Mutation | novel | c.599N>A | p.Arg200Gln | p.R200Q | Q13206 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| DDX10 | SNV | Missense_Mutation | c.2039N>T | p.Arg680Ile | p.R680I | Q13206 | protein_coding | deleterious(0) | possibly_damaging(0.564) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| DDX10 | SNV | Missense_Mutation | c.1832N>A | p.Ser611Asn | p.S611N | Q13206 | protein_coding | tolerated(0.54) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| DDX10 | SNV | Missense_Mutation | c.788T>G | p.Leu263Arg | p.L263R | Q13206 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4684-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | folfox | PD |
| Page: 1 2 3 4 5 6 7 8 9 10 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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