Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DCTN3

Gene summary for DCTN3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DCTN3

Gene ID

11258

Gene namedynactin subunit 3
Gene AliasDCTN-22
Cytomap9p13.3
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

O75935


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11258DCTN3CA_HPV_1HumanCervixCC8.76e-09-2.65e-010.0264
11258DCTN3CA_HPV_3HumanCervixCC4.86e-031.48e-010.0414
11258DCTN3CCI_1HumanCervixCC3.78e-04-4.77e-010.528
11258DCTN3CCI_3HumanCervixCC1.37e-10-5.17e-010.516
11258DCTN3CCII_1HumanCervixCC5.99e-15-5.17e-010.3249
11258DCTN3H2HumanCervixHSIL_HPV1.07e-02-2.76e-010.0632
11258DCTN3HTA11_2487_2000001011HumanColorectumSER1.21e-032.87e-01-0.1808
11258DCTN3HTA11_1938_2000001011HumanColorectumAD8.38e-062.96e-01-0.0811
11258DCTN3HTA11_347_2000001011HumanColorectumAD3.17e-052.23e-01-0.1954
11258DCTN3HTA11_3361_2000001011HumanColorectumAD8.19e-052.97e-01-0.1207
11258DCTN3HTA11_83_2000001011HumanColorectumSER3.88e-022.46e-01-0.1526
11258DCTN3HTA11_696_2000001011HumanColorectumAD7.49e-072.31e-01-0.1464
11258DCTN3HTA11_866_2000001011HumanColorectumAD1.22e-041.15e-01-0.1001
11258DCTN3HTA11_1391_2000001011HumanColorectumAD2.82e-093.76e-01-0.059
11258DCTN3HTA11_546_2000001011HumanColorectumAD7.67e-032.63e-01-0.0842
11258DCTN3HTA11_866_3004761011HumanColorectumAD1.19e-093.17e-010.096
11258DCTN3HTA11_10711_2000001011HumanColorectumAD1.06e-022.27e-010.0338
11258DCTN3HTA11_7696_3000711011HumanColorectumAD3.03e-143.52e-010.0674
11258DCTN3HTA11_6818_2000001021HumanColorectumAD1.00e-032.76e-010.0588
11258DCTN3HTA11_99999970781_79442HumanColorectumMSS4.69e-062.10e-010.294
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00009107CervixCCcytokinesis37/2311173/187235.40e-045.23e-0337
GO:0000910ColorectumADcytokinesis59/3918173/187233.74e-056.75e-0459
GO:0061640ColorectumADcytoskeleton-dependent cytokinesis37/3918100/187231.58e-042.20e-0337
GO:00009101ColorectumSERcytokinesis45/2897173/187232.28e-043.93e-0345
GO:00616401ColorectumSERcytoskeleton-dependent cytokinesis29/2897100/187234.25e-046.25e-0329
GO:00009102ColorectumMSScytokinesis49/3467173/187231.02e-031.02e-0249
GO:00009108EndometriumAEHcytokinesis40/2100173/187236.01e-061.49e-0440
GO:00616403EndometriumAEHcytoskeleton-dependent cytokinesis24/2100100/187232.27e-042.75e-0324
GO:000091013EndometriumEECcytokinesis40/2168173/187231.29e-052.60e-0440
GO:006164012EndometriumEECcytoskeleton-dependent cytokinesis24/2168100/187233.66e-043.95e-0324
GO:000091015EsophagusHGINcytokinesis44/2587173/187233.26e-058.32e-0444
GO:00616406EsophagusHGINcytoskeleton-dependent cytokinesis27/2587100/187233.71e-045.77e-0327
GO:000091016EsophagusESCCcytokinesis115/8552173/187232.48e-084.68e-07115
GO:006164015EsophagusESCCcytoskeleton-dependent cytokinesis72/8552100/187238.10e-081.39e-0672
GO:00009105LiverCirrhoticcytokinesis62/4634173/187237.13e-045.33e-0362
GO:00616402LiverCirrhoticcytoskeleton-dependent cytokinesis38/4634100/187232.22e-031.35e-0238
GO:000091011LiverHCCcytokinesis100/7958173/187233.38e-053.39e-04100
GO:006164011LiverHCCcytoskeleton-dependent cytokinesis60/7958100/187233.09e-042.20e-0360
GO:000091010Oral cavityOSCCcytokinesis97/7305173/187233.82e-064.51e-0597
GO:00616405Oral cavityOSCCcytoskeleton-dependent cytokinesis60/7305100/187231.69e-051.67e-0460
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501618CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa0502218CervixCCPathways of neurodegeneration - multiple diseases128/1267476/84652.87e-129.29e-115.50e-11128
hsa0501418CervixCCAmyotrophic lateral sclerosis103/1267364/84651.79e-114.47e-102.64e-10103
hsa0513220CervixCCSalmonella infection74/1267249/84651.33e-092.54e-081.50e-0874
hsa0501619CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa0502219CervixCCPathways of neurodegeneration - multiple diseases128/1267476/84652.87e-129.29e-115.50e-11128
hsa0501419CervixCCAmyotrophic lateral sclerosis103/1267364/84651.79e-114.47e-102.64e-10103
hsa05132110CervixCCSalmonella infection74/1267249/84651.33e-092.54e-081.50e-0874
hsa0513225CervixHSIL_HPVSalmonella infection34/459249/84655.03e-071.13e-059.17e-0634
hsa0501624CervixHSIL_HPVHuntington disease38/459306/84651.21e-062.54e-052.05e-0538
hsa0502224CervixHSIL_HPVPathways of neurodegeneration - multiple diseases46/459476/84658.10e-051.08e-038.72e-0446
hsa0501424CervixHSIL_HPVAmyotrophic lateral sclerosis35/459364/84656.43e-045.23e-034.23e-0335
hsa0513235CervixHSIL_HPVSalmonella infection34/459249/84655.03e-071.13e-059.17e-0634
hsa0501634CervixHSIL_HPVHuntington disease38/459306/84651.21e-062.54e-052.05e-0538
hsa0502234CervixHSIL_HPVPathways of neurodegeneration - multiple diseases46/459476/84658.10e-051.08e-038.72e-0446
hsa0501434CervixHSIL_HPVAmyotrophic lateral sclerosis35/459364/84656.43e-045.23e-034.23e-0335
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa05022ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DCTN3SNVMissense_Mutationc.169N>Ap.Leu57Ilep.L57IO75935protein_codingdeleterious(0.03)probably_damaging(0.913)TCGA-CA-6718-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownPD
DCTN3SNVMissense_Mutationc.164A>Gp.Lys55Argp.K55RO75935protein_codingdeleterious(0.02)probably_damaging(0.966)TCGA-CK-6746-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
DCTN3SNVMissense_Mutationc.397N>Ap.His133Asnp.H133NO75935protein_codingtolerated(0.09)possibly_damaging(0.843)TCGA-DM-A1HB-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownSD
DCTN3SNVMissense_Mutationnovelc.146N>Ap.Ser49Asnp.S49NO75935protein_codingtolerated(0.68)benign(0.007)TCGA-A5-A2K3-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapycarboplatinSD
DCTN3SNVMissense_Mutationnovelc.32N>Cp.Gln11Prop.Q11PO75935protein_codingdeleterious(0.01)possibly_damaging(0.648)TCGA-B5-A1MW-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownPD
DCTN3SNVMissense_Mutationnovelc.143C>Tp.Ser48Phep.S48FO75935protein_codingdeleterious(0.02)benign(0.432)TCGA-D1-A103-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
DCTN3SNVMissense_Mutationnovelc.377N>Gp.Leu126Argp.L126RO75935protein_codingdeleterious(0)probably_damaging(0.996)TCGA-EO-A22S-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
DCTN3SNVMissense_Mutationnovelc.494T>Cp.Phe165Serp.F165SO75935protein_codingdeleterious(0)possibly_damaging(0.88)TCGA-EO-A22X-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnspecificCarboplatinComplete Response
DCTN3SNVMissense_Mutationnovelc.220N>Ap.Asp74Asnp.D74NO75935protein_codingdeleterious(0)possibly_damaging(0.789)TCGA-EO-A3AY-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownPD
DCTN3SNVMissense_Mutationnovelc.220G>Ap.Asp74Asnp.D74NO75935protein_codingdeleterious(0)possibly_damaging(0.789)TCGA-EO-A3AZ-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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