Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DCN

Gene summary for DCN

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DCN

Gene ID

1634

Gene namedecorin
Gene AliasCSCD
Cytomap12q21.33
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

P07585


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1634DCNCA_HPV_3HumanCervixCC4.52e-357.84e-010.0414
1634DCNN_HPV_2HumanCervixN_HPV1.22e-145.18e-01-0.0131
1634DCNT1HumanCervixCC2.52e-02-1.67e-010.0918
1634DCNAEH-subject1HumanEndometriumAEH1.52e-43-9.66e-01-0.3059
1634DCNAEH-subject2HumanEndometriumAEH7.87e-43-1.11e+00-0.2525
1634DCNAEH-subject3HumanEndometriumAEH5.65e-46-1.10e+00-0.2576
1634DCNAEH-subject4HumanEndometriumAEH1.13e-08-6.38e-01-0.2657
1634DCNAEH-subject5HumanEndometriumAEH2.31e-52-1.14e+00-0.2953
1634DCNEEC-subject1HumanEndometriumEEC4.30e-54-1.15e+00-0.2682
1634DCNEEC-subject2HumanEndometriumEEC2.14e-57-1.18e+00-0.2607
1634DCNEEC-subject3HumanEndometriumEEC4.89e-42-9.52e-01-0.2525
1634DCNEEC-subject4HumanEndometriumEEC5.83e-35-9.00e-01-0.2571
1634DCNEEC-subject5HumanEndometriumEEC1.09e-49-1.09e+00-0.249
1634DCNGSM5276935HumanEndometriumEEC1.70e-54-1.14e+00-0.123
1634DCNGSM5276937HumanEndometriumEEC5.72e-14-6.91e-01-0.0897
1634DCNGSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC2.21e-44-1.19e+00-0.1869
1634DCNGSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC4.75e-43-1.20e+00-0.1875
1634DCNGSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC2.73e-49-1.20e+00-0.1883
1634DCNGSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC2.76e-62-1.19e+00-0.1934
1634DCNGSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC2.62e-65-1.20e+00-0.1917
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004206010CervixCCwound healing109/2311422/187231.84e-141.57e-11109
GO:009013210CervixCCepithelium migration90/2311360/187232.45e-116.11e-0990
GO:00016679CervixCCameboidal-type cell migration110/2311475/187232.66e-116.36e-09110
GO:001063110CervixCCepithelial cell migration89/2311357/187233.72e-118.54e-0989
GO:009013010CervixCCtissue migration90/2311365/187235.42e-111.05e-0890
GO:000989610CervixCCpositive regulation of catabolic process109/2311492/187235.26e-106.99e-08109
GO:001063210CervixCCregulation of epithelial cell migration72/2311292/187234.52e-094.43e-0772
GO:003133110CervixCCpositive regulation of cellular catabolic process91/2311427/187239.64e-085.25e-0691
GO:00075689CervixCCaging75/2311339/187232.75e-071.13e-0575
GO:00018908CervixCCplacenta development40/2311144/187234.59e-071.77e-0540
GO:00022379CervixCCresponse to molecule of bacterial origin78/2311363/187235.55e-072.06e-0578
GO:00324969CervixCCresponse to lipopolysaccharide74/2311343/187239.15e-073.25e-0574
GO:00614588CervixCCreproductive system development87/2311427/187231.37e-064.55e-0587
GO:00486088CervixCCreproductive structure development86/2311424/187231.90e-065.97e-0586
GO:00435427CervixCCendothelial cell migration60/2311279/187231.05e-052.33e-0460
GO:00105944CervixCCregulation of endothelial cell migration52/2311232/187231.20e-052.54e-0452
GO:00512713CervixCCnegative regulation of cellular component movement73/2311367/187232.22e-053.95e-0473
GO:00096127CervixCCresponse to mechanical stimulus48/2311216/187233.23e-055.29e-0448
GO:00400133CervixCCnegative regulation of locomotion76/2311391/187233.47e-055.60e-0476
GO:20001463CervixCCnegative regulation of cell motility71/2311359/187233.47e-055.60e-0471
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0520516CervixCCProteoglycans in cancer60/1267205/84659.13e-081.18e-067.00e-0760
hsa0520517CervixCCProteoglycans in cancer60/1267205/84659.13e-081.18e-067.00e-0760
hsa0520518EndometriumAEHProteoglycans in cancer53/1197205/84655.43e-066.53e-054.78e-0553
hsa043504EndometriumAEHTGF-beta signaling pathway26/1197108/84653.82e-032.18e-021.59e-0226
hsa0520519EndometriumAEHProteoglycans in cancer53/1197205/84655.43e-066.53e-054.78e-0553
hsa0435011EndometriumAEHTGF-beta signaling pathway26/1197108/84653.82e-032.18e-021.59e-0226
hsa0520524EndometriumEECProteoglycans in cancer52/1237205/84653.01e-053.19e-042.38e-0452
hsa043502EndometriumEECTGF-beta signaling pathway26/1237108/84655.95e-033.12e-022.33e-0226
hsa0520534EndometriumEECProteoglycans in cancer52/1237205/84653.01e-053.19e-042.38e-0452
hsa043503EndometriumEECTGF-beta signaling pathway26/1237108/84655.95e-033.12e-022.33e-0226
hsa0520529EsophagusESCCProteoglycans in cancer138/4205205/84651.79e-071.40e-067.15e-07138
hsa043507EsophagusESCCTGF-beta signaling pathway69/4205108/84651.92e-035.54e-032.84e-0369
hsa0520537EsophagusESCCProteoglycans in cancer138/4205205/84651.79e-071.40e-067.15e-07138
hsa0435014EsophagusESCCTGF-beta signaling pathway69/4205108/84651.92e-035.54e-032.84e-0369
hsa0520526Oral cavityOSCCProteoglycans in cancer128/3704205/84654.00e-083.12e-071.59e-07128
hsa043506Oral cavityOSCCTGF-beta signaling pathway60/3704108/84658.66e-031.97e-021.00e-0260
hsa05205111Oral cavityOSCCProteoglycans in cancer128/3704205/84654.00e-083.12e-071.59e-07128
hsa0435013Oral cavityOSCCTGF-beta signaling pathway60/3704108/84658.66e-031.97e-021.00e-0260
hsa0520527Oral cavityLPProteoglycans in cancer77/2418205/84653.01e-031.29e-028.35e-0377
hsa0520536Oral cavityLPProteoglycans in cancer77/2418205/84653.01e-031.29e-028.35e-0377
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DCNSNVMissense_Mutationc.912N>Gp.Ile304Metp.I304MP07585protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
DCNSNVMissense_Mutationrs777073492c.569N>Ap.Gly190Glup.G190EP07585protein_codingtolerated(0.06)probably_damaging(1)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
DCNSNVMissense_Mutationc.368N>Cp.Gly123Alap.G123AP07585protein_codingtolerated(0.15)benign(0.003)TCGA-D8-A1J8-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapynolvadexSD
DCNinsertionNonsense_Mutationnovelc.404_405insGTGCTTAACTACAGATATTTTGAGATACCp.Tyr135Terp.Y135*P07585protein_codingTCGA-A8-A08P-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilCR
DCNinsertionFrame_Shift_Insnovelc.390_391insGATATTATAAGGAATAGGAGACTATGTCCAATCACGTTCTGTCAGAp.Leu131AspfsTer44p.L131Dfs*44P07585protein_codingTCGA-A8-A09K-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
DCNSNVMissense_Mutationnovelc.849N>Cp.Arg283Serp.R283SP07585protein_codingtolerated(0.31)benign(0.001)TCGA-AA-3966-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
DCNSNVMissense_Mutationc.425N>Cp.Lys142Thrp.K142TP07585protein_codingtolerated(1)benign(0.011)TCGA-AD-6548-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
DCNSNVMissense_Mutationnovelc.449N>Cp.Lys150Thrp.K150TP07585protein_codingtolerated(0.07)possibly_damaging(0.467)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
DCNSNVMissense_Mutationc.283N>Ap.Glu95Lysp.E95KP07585protein_codingtolerated(0.09)probably_damaging(0.995)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
DCNSNVMissense_Mutationc.563N>Tp.Ser188Ilep.S188IP07585protein_codingdeleterious(0)probably_damaging(0.921)TCGA-CK-6746-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
1634DCNDRUGGABLE GENOMEIFN12707320
1634DCNDRUGGABLE GENOMEHSP709292805
1634DCNDRUGGABLE GENOMEASCORBIC ACID7944410
1634DCNDRUGGABLE GENOMERAPAMYCINSIROLIMUS17200203
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