![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DCAF7 |
Gene summary for DCAF7 |
![]() |
Gene information | Species | Human | Gene symbol | DCAF7 | Gene ID | 10238 |
Gene name | DDB1 and CUL4 associated factor 7 | |
Gene Alias | AN11 | |
Cytomap | 17q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | P61962 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10238 | DCAF7 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.58e-05 | 4.77e-01 | -0.1088 |
10238 | DCAF7 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.28e-13 | 6.03e-01 | -0.1954 |
10238 | DCAF7 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.94e-08 | 5.65e-01 | -0.1464 |
10238 | DCAF7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.62e-08 | 6.65e-01 | -0.059 |
10238 | DCAF7 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.19e-03 | 5.59e-01 | -0.0842 |
10238 | DCAF7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.91e-02 | 3.65e-01 | 0.0338 |
10238 | DCAF7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.14e-11 | 6.32e-01 | 0.0674 |
10238 | DCAF7 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.92e-05 | 1.00e+00 | 0.3487 |
10238 | DCAF7 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.30e-15 | 1.08e+00 | 0.281 |
10238 | DCAF7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.09e-05 | 6.44e-01 | 0.3859 |
10238 | DCAF7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.86e-09 | 5.86e-01 | 0.3005 |
10238 | DCAF7 | A015-C-203 | Human | Colorectum | FAP | 1.61e-16 | -2.59e-01 | -0.1294 |
10238 | DCAF7 | A015-C-204 | Human | Colorectum | FAP | 1.07e-03 | -2.18e-01 | -0.0228 |
10238 | DCAF7 | A014-C-040 | Human | Colorectum | FAP | 1.69e-02 | -4.06e-01 | -0.1184 |
10238 | DCAF7 | A002-C-201 | Human | Colorectum | FAP | 1.17e-06 | -2.31e-01 | 0.0324 |
10238 | DCAF7 | A002-C-203 | Human | Colorectum | FAP | 1.13e-02 | -7.26e-02 | 0.2786 |
10238 | DCAF7 | A001-C-119 | Human | Colorectum | FAP | 4.05e-03 | -3.22e-01 | -0.1557 |
10238 | DCAF7 | A001-C-108 | Human | Colorectum | FAP | 6.19e-11 | -2.44e-01 | -0.0272 |
10238 | DCAF7 | A002-C-205 | Human | Colorectum | FAP | 1.79e-11 | -2.94e-01 | -0.1236 |
10238 | DCAF7 | A001-C-104 | Human | Colorectum | FAP | 2.39e-04 | -2.18e-01 | 0.0184 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCAF7 | SNV | Missense_Mutation | novel | c.676N>T | p.Arg226Cys | p.R226C | P61962 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A3XZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
DCAF7 | SNV | Missense_Mutation | novel | c.757N>T | p.Arg253Trp | p.R253W | P61962 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1FE-06 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DCAF7 | SNV | Missense_Mutation | novel | c.797G>A | p.Arg266Gln | p.R266Q | P61962 | protein_coding | tolerated(0.43) | benign(0.063) | TCGA-D8-A1JT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
DCAF7 | SNV | Missense_Mutation | novel | c.901C>G | p.Arg301Gly | p.R301G | P61962 | protein_coding | tolerated(0.18) | benign(0.006) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
DCAF7 | SNV | Missense_Mutation | novel | c.247G>A | p.Val83Ile | p.V83I | P61962 | protein_coding | tolerated(0.3) | benign(0) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
DCAF7 | SNV | Missense_Mutation | novel | c.299T>C | p.Val100Ala | p.V100A | P61962 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DCAF7 | SNV | Missense_Mutation | novel | c.988N>A | p.Ala330Thr | p.A330T | P61962 | protein_coding | deleterious(0) | possibly_damaging(0.626) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DCAF7 | SNV | Missense_Mutation | novel | c.382T>C | p.Trp128Arg | p.W128R | P61962 | protein_coding | deleterious(0) | possibly_damaging(0.863) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
DCAF7 | SNV | Missense_Mutation | novel | c.383G>T | p.Trp128Leu | p.W128L | P61962 | protein_coding | deleterious(0) | possibly_damaging(0.768) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
DCAF7 | SNV | Missense_Mutation | novel | c.649N>A | p.Glu217Lys | p.E217K | P61962 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |