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Gene: DARS2 |
Gene summary for DARS2 |
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Gene information | Species | Human | Gene symbol | DARS2 | Gene ID | 55157 |
Gene name | aspartyl-tRNA synthetase 2, mitochondrial | |
Gene Alias | ASPRS | |
Cytomap | 1q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | A0A024R8Z9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55157 | DARS2 | LZE2T | Human | Esophagus | ESCC | 7.05e-07 | 6.75e-01 | 0.082 |
55157 | DARS2 | LZE7T | Human | Esophagus | ESCC | 5.24e-03 | 1.75e-01 | 0.0667 |
55157 | DARS2 | LZE24T | Human | Esophagus | ESCC | 5.69e-05 | 1.51e-01 | 0.0596 |
55157 | DARS2 | P1T-E | Human | Esophagus | ESCC | 5.57e-03 | 1.45e-01 | 0.0875 |
55157 | DARS2 | P2T-E | Human | Esophagus | ESCC | 3.32e-10 | 2.31e-01 | 0.1177 |
55157 | DARS2 | P4T-E | Human | Esophagus | ESCC | 2.75e-09 | 3.02e-01 | 0.1323 |
55157 | DARS2 | P5T-E | Human | Esophagus | ESCC | 1.33e-08 | 2.05e-01 | 0.1327 |
55157 | DARS2 | P8T-E | Human | Esophagus | ESCC | 2.42e-05 | 5.37e-02 | 0.0889 |
55157 | DARS2 | P9T-E | Human | Esophagus | ESCC | 7.03e-06 | 1.49e-01 | 0.1131 |
55157 | DARS2 | P10T-E | Human | Esophagus | ESCC | 3.77e-03 | 8.75e-02 | 0.116 |
55157 | DARS2 | P12T-E | Human | Esophagus | ESCC | 6.14e-08 | 1.21e-01 | 0.1122 |
55157 | DARS2 | P15T-E | Human | Esophagus | ESCC | 1.73e-11 | 1.83e-01 | 0.1149 |
55157 | DARS2 | P16T-E | Human | Esophagus | ESCC | 4.44e-14 | 2.16e-01 | 0.1153 |
55157 | DARS2 | P17T-E | Human | Esophagus | ESCC | 1.04e-02 | 1.54e-01 | 0.1278 |
55157 | DARS2 | P20T-E | Human | Esophagus | ESCC | 2.26e-15 | 1.70e-01 | 0.1124 |
55157 | DARS2 | P21T-E | Human | Esophagus | ESCC | 7.01e-11 | 2.81e-01 | 0.1617 |
55157 | DARS2 | P22T-E | Human | Esophagus | ESCC | 1.09e-06 | 1.45e-01 | 0.1236 |
55157 | DARS2 | P23T-E | Human | Esophagus | ESCC | 5.93e-10 | 2.22e-01 | 0.108 |
55157 | DARS2 | P24T-E | Human | Esophagus | ESCC | 8.61e-10 | 1.91e-01 | 0.1287 |
55157 | DARS2 | P26T-E | Human | Esophagus | ESCC | 1.42e-09 | 1.95e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0000959 | Liver | HCC | mitochondrial RNA metabolic process | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DARS2 | SNV | Missense_Mutation | c.928N>C | p.Asp310His | p.D310H | Q6PI48 | protein_coding | tolerated(0.17) | possibly_damaging(0.479) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
DARS2 | SNV | Missense_Mutation | c.1603G>A | p.Glu535Lys | p.E535K | Q6PI48 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DARS2 | SNV | Missense_Mutation | novel | c.996N>C | p.Lys332Asn | p.K332N | Q6PI48 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
DARS2 | SNV | Missense_Mutation | c.1489C>G | p.Leu497Val | p.L497V | Q6PI48 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
DARS2 | SNV | Missense_Mutation | novel | c.996A>C | p.Lys332Asn | p.K332N | Q6PI48 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
DARS2 | SNV | Missense_Mutation | c.694N>A | p.Glu232Lys | p.E232K | Q6PI48 | protein_coding | tolerated(0.39) | possibly_damaging(0.904) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DARS2 | SNV | Missense_Mutation | c.1900T>A | p.Ser634Thr | p.S634T | Q6PI48 | protein_coding | tolerated(0.35) | benign(0.098) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
DARS2 | insertion | Frame_Shift_Ins | novel | c.1534_1535insCC | p.Ile512ThrfsTer21 | p.I512Tfs*21 | Q6PI48 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
DARS2 | insertion | Nonsense_Mutation | novel | c.1535_1536insTCAAGAGAAGTGAGGAAATAATCAGAACGACTACCACTC | p.Ile512_His513insGlnGluLysTerGlyAsnAsnGlnAsnAspTyrHisSer | p.I512_H513insQEK*GNNQNDYHS | Q6PI48 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
DARS2 | insertion | In_Frame_Ins | novel | c.1494_1495insACCAGACTTTCGAGGAATAACATTAACATTCTGAAAATG | p.Glu498_Ser499insThrArgLeuSerArgAsnAsnIleAsnIleLeuLysMet | p.E498_S499insTRLSRNNINILKM | Q6PI48 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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