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Gene: CYYR1 |
Gene summary for CYYR1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CYYR1 | Gene ID | 116159 |
| Gene name | cysteine and tyrosine rich 1 | |
| Gene Alias | C21orf95 | |
| Cytomap | 21q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96J86 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 116159 | CYYR1 | P2T-E | Human | Esophagus | ESCC | 1.62e-03 | 8.80e-02 | 0.1177 |
| 116159 | CYYR1 | P5T-E | Human | Esophagus | ESCC | 5.44e-06 | 9.39e-02 | 0.1327 |
| 116159 | CYYR1 | P10T-E | Human | Esophagus | ESCC | 3.88e-81 | 1.39e+00 | 0.116 |
| 116159 | CYYR1 | P11T-E | Human | Esophagus | ESCC | 1.06e-05 | 3.20e-01 | 0.1426 |
| 116159 | CYYR1 | P12T-E | Human | Esophagus | ESCC | 4.43e-17 | 3.52e-01 | 0.1122 |
| 116159 | CYYR1 | P23T-E | Human | Esophagus | ESCC | 7.15e-05 | 3.07e-01 | 0.108 |
| 116159 | CYYR1 | P36T-E | Human | Esophagus | ESCC | 9.47e-03 | 3.12e-01 | 0.1187 |
| 116159 | CYYR1 | P42T-E | Human | Esophagus | ESCC | 7.53e-05 | 1.18e-01 | 0.1175 |
| 116159 | CYYR1 | P56T-E | Human | Esophagus | ESCC | 6.03e-06 | 6.62e-01 | 0.1613 |
| 116159 | CYYR1 | P57T-E | Human | Esophagus | ESCC | 9.30e-03 | 1.54e-01 | 0.0926 |
| 116159 | CYYR1 | P62T-E | Human | Esophagus | ESCC | 6.10e-03 | 4.42e-02 | 0.1302 |
| 116159 | CYYR1 | P65T-E | Human | Esophagus | ESCC | 2.59e-15 | 9.29e-02 | 0.0978 |
| 116159 | CYYR1 | P74T-E | Human | Esophagus | ESCC | 4.67e-20 | 6.30e-01 | 0.1479 |
| 116159 | CYYR1 | P76T-E | Human | Esophagus | ESCC | 1.92e-04 | 1.07e-01 | 0.1207 |
| 116159 | CYYR1 | P107T-E | Human | Esophagus | ESCC | 4.60e-20 | 2.90e-01 | 0.171 |
| 116159 | CYYR1 | P130T-E | Human | Esophagus | ESCC | 3.56e-23 | 6.88e-01 | 0.1676 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CYYR1 | SNV | Missense_Mutation | novel | c.275N>T | p.Arg92Met | p.R92M | Q96J86 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| CYYR1 | SNV | Missense_Mutation | c.26G>A | p.Arg9His | p.R9H | Q96J86 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-A6-6649-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
| CYYR1 | SNV | Missense_Mutation | rs150622120 | c.191C>T | p.Ala64Val | p.A64V | Q96J86 | protein_coding | deleterious(0.01) | possibly_damaging(0.474) | TCGA-CA-6716-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | CR |
| CYYR1 | SNV | Missense_Mutation | novel | c.356A>T | p.Asp119Val | p.D119V | Q96J86 | protein_coding | deleterious(0) | possibly_damaging(0.582) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| CYYR1 | SNV | Missense_Mutation | c.206G>A | p.Gly69Glu | p.G69E | Q96J86 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| CYYR1 | SNV | Missense_Mutation | c.85N>A | p.Ala29Thr | p.A29T | Q96J86 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CYYR1 | SNV | Missense_Mutation | c.382N>A | p.Leu128Met | p.L128M | Q96J86 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CYYR1 | SNV | Missense_Mutation | rs143400859 | c.302C>T | p.Thr101Met | p.T101M | Q96J86 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| CYYR1 | SNV | Missense_Mutation | rs147481963 | c.278C>T | p.Ala93Val | p.A93V | Q96J86 | protein_coding | deleterious(0) | benign(0.172) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CYYR1 | SNV | Missense_Mutation | rs145305731 | c.454G>A | p.Ala152Thr | p.A152T | Q96J86 | protein_coding | tolerated_low_confidence(0.22) | benign(0.027) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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