Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CYTH1

Gene summary for CYTH1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CYTH1

Gene ID

9267

Gene namecytohesin 1
Gene AliasB2-1
Cytomap17q25.3
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

Q15438


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9267CYTH1CA_HPV_1HumanCervixCC1.21e-022.43e-010.0264
9267CYTH1CCI_2HumanCervixCC2.02e-037.76e-010.5249
9267CYTH1CCI_3HumanCervixCC3.72e-078.23e-010.516
9267CYTH1AEH-subject1HumanEndometriumAEH1.35e-144.75e-01-0.3059
9267CYTH1AEH-subject2HumanEndometriumAEH3.24e-032.70e-01-0.2525
9267CYTH1AEH-subject3HumanEndometriumAEH5.30e-033.16e-01-0.2576
9267CYTH1AEH-subject4HumanEndometriumAEH9.62e-237.01e-01-0.2657
9267CYTH1AEH-subject5HumanEndometriumAEH1.92e-318.59e-01-0.2953
9267CYTH1EEC-subject1HumanEndometriumEEC1.92e-155.80e-01-0.2682
9267CYTH1EEC-subject2HumanEndometriumEEC6.27e-073.31e-01-0.2607
9267CYTH1EEC-subject3HumanEndometriumEEC7.64e-033.25e-01-0.2525
9267CYTH1EEC-subject4HumanEndometriumEEC5.65e-125.38e-01-0.2571
9267CYTH1EEC-subject5HumanEndometriumEEC1.12e-135.16e-01-0.249
9267CYTH1GSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC9.84e-03-1.16e-01-0.1869
9267CYTH1GSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC1.63e-023.13e-02-0.1875
9267CYTH1GSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC6.34e-04-9.90e-02-0.1883
9267CYTH1GSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC4.99e-06-7.50e-02-0.1917
9267CYTH1GSM6177622_NYU_UCEC3_lib2_lib2HumanEndometriumEEC2.45e-03-6.86e-02-0.1916
9267CYTH1LZE4THumanEsophagusESCC1.20e-092.95e-010.0811
9267CYTH1LZE5THumanEsophagusESCC1.69e-082.53e-010.0514
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00071639CervixCCestablishment or maintenance of cell polarity63/2311218/187234.25e-118.76e-0963
GO:00510566CervixCCregulation of small GTPase mediated signal transduction75/2311302/187231.54e-091.74e-0775
GO:00072656CervixCCRas protein signal transduction79/2311337/187239.49e-097.77e-0779
GO:00300108CervixCCestablishment of cell polarity42/2311143/187234.30e-082.62e-0642
GO:00465785CervixCCregulation of Ras protein signal transduction44/2311189/187232.05e-053.73e-0444
GO:00901627CervixCCestablishment of epithelial cell polarity11/231131/187237.87e-046.96e-0311
GO:000716310EndometriumAEHestablishment or maintenance of cell polarity54/2100218/187231.30e-088.47e-0754
GO:00300109EndometriumAEHestablishment of cell polarity36/2100143/187232.19e-066.49e-0536
GO:00510567EndometriumAEHregulation of small GTPase mediated signal transduction59/2100302/187231.43e-053.03e-0459
GO:00072657EndometriumAEHRas protein signal transduction63/2100337/187233.09e-055.66e-0463
GO:00465786EndometriumAEHregulation of Ras protein signal transduction36/2100189/187231.01e-038.97e-0336
GO:00901628EndometriumAEHestablishment of epithelial cell polarity10/210031/187231.48e-031.23e-0210
GO:000716315EndometriumEECestablishment or maintenance of cell polarity56/2168218/187235.41e-093.57e-0756
GO:003001014EndometriumEECestablishment of cell polarity36/2168143/187234.57e-061.15e-0436
GO:005105612EndometriumEECregulation of small GTPase mediated signal transduction61/2168302/187239.42e-062.08e-0461
GO:000726513EndometriumEECRas protein signal transduction64/2168337/187234.31e-057.10e-0464
GO:004657813EndometriumEECregulation of Ras protein signal transduction37/2168189/187239.23e-048.32e-0337
GO:009016213EndometriumEECestablishment of epithelial cell polarity10/216831/187231.89e-031.45e-0210
GO:000716320EsophagusESCCestablishment or maintenance of cell polarity143/8552218/187232.05e-094.65e-08143
GO:000726510EsophagusESCCRas protein signal transduction201/8552337/187231.44e-072.30e-06201
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0513020CervixCCPathogenic Escherichia coli infection63/1267197/84659.28e-102.00e-081.19e-0863
hsa0513220CervixCCSalmonella infection74/1267249/84651.33e-092.54e-081.50e-0874
hsa0513120CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa0414418CervixCCEndocytosis64/1267251/84656.97e-066.10e-053.61e-0564
hsa05130110CervixCCPathogenic Escherichia coli infection63/1267197/84659.28e-102.00e-081.19e-0863
hsa05132110CervixCCSalmonella infection74/1267249/84651.33e-092.54e-081.50e-0874
hsa05131110CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa0414419CervixCCEndocytosis64/1267251/84656.97e-066.10e-053.61e-0564
hsa0513126EndometriumAEHShigellosis78/1197247/84659.23e-132.00e-111.46e-1178
hsa0513226EndometriumAEHSalmonella infection71/1197249/84651.69e-093.44e-082.52e-0871
hsa0513026EndometriumAEHPathogenic Escherichia coli infection50/1197197/84651.72e-051.86e-041.36e-0450
hsa0414420EndometriumAEHEndocytosis56/1197251/84652.58e-042.15e-031.57e-0356
hsa05131111EndometriumAEHShigellosis78/1197247/84659.23e-132.00e-111.46e-1178
hsa05132112EndometriumAEHSalmonella infection71/1197249/84651.69e-093.44e-082.52e-0871
hsa05130112EndometriumAEHPathogenic Escherichia coli infection50/1197197/84651.72e-051.86e-041.36e-0450
hsa04144110EndometriumAEHEndocytosis56/1197251/84652.58e-042.15e-031.57e-0356
hsa0513127EndometriumEECShigellosis79/1237247/84651.80e-123.95e-112.95e-1179
hsa0513227EndometriumEECSalmonella infection71/1237249/84657.11e-091.30e-079.69e-0871
hsa0513027EndometriumEECPathogenic Escherichia coli infection51/1237197/84651.98e-052.28e-041.70e-0451
hsa0414424EndometriumEECEndocytosis57/1237251/84653.34e-042.82e-032.10e-0357
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CYTH1insertionFrame_Shift_Insnovelc.1142_1143insGTTTGTTTGTTTTTGCCp.Phe381LeufsTer65p.F381Lfs*65Q15438protein_codingTCGA-A8-A09C-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CYTH1deletionIn_Frame_Delc.1093_1095delNNNp.Lys365delp.K365delQ15438protein_codingTCGA-BH-A18K-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
CYTH1SNVMissense_Mutationnovelc.52C>Gp.Gln18Glup.Q18EQ15438protein_codingtolerated(1)benign(0)TCGA-EA-A43B-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
CYTH1SNVMissense_Mutationc.973G>Cp.Glu325Glnp.E325QQ15438protein_codingdeleterious(0)probably_damaging(0.999)TCGA-JX-A3Q0-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
CYTH1SNVMissense_Mutationc.215N>Cp.Lys72Thrp.K72TQ15438protein_codingdeleterious(0)possibly_damaging(0.887)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
CYTH1SNVMissense_Mutationc.734A>Cp.Lys245Thrp.K245TQ15438protein_codingdeleterious(0.01)benign(0.245)TCGA-CA-6718-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownPD
CYTH1SNVMissense_Mutationnovelc.554N>Ap.Thr185Asnp.T185NQ15438protein_codingdeleterious(0)probably_damaging(0.975)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
CYTH1SNVMissense_Mutationrs778692007c.811G>Ap.Gly271Argp.G271RQ15438protein_codingtolerated(0.2)possibly_damaging(0.807)TCGA-DY-A1H8-01Colorectumrectum adenocarcinomaFemale>=65III/IVUnknownUnknownSD
CYTH1insertionFrame_Shift_Insnovelc.639dupGp.Phe214ValfsTer10p.F214Vfs*10Q15438protein_codingTCGA-AA-3860-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyfolinicCR
CYTH1insertionFrame_Shift_Insnovelc.728_729insTAAGTCTCAGp.Phe244LysfsTer5p.F244Kfs*5Q15438protein_codingTCGA-AM-5820-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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