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Gene: CYREN |
Gene summary for CYREN |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CYREN | Gene ID | 78996 |
| Gene name | cell cycle regulator of NHEJ | |
| Gene Alias | C7orf49 | |
| Cytomap | 7q33 | |
| Gene Type | protein-coding | GO ID | GO:0002200 | UniProtAcc | Q9BWK5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 78996 | CYREN | S014 | Human | Liver | HCC | 7.27e-36 | 9.45e-01 | 0.2254 |
| 78996 | CYREN | S015 | Human | Liver | HCC | 3.31e-28 | 1.06e+00 | 0.2375 |
| 78996 | CYREN | S016 | Human | Liver | HCC | 4.96e-28 | 7.31e-01 | 0.2243 |
| 78996 | CYREN | S027 | Human | Liver | HCC | 4.81e-08 | 7.00e-01 | 0.2446 |
| 78996 | CYREN | S028 | Human | Liver | HCC | 2.95e-24 | 8.53e-01 | 0.2503 |
| 78996 | CYREN | S029 | Human | Liver | HCC | 1.31e-19 | 7.31e-01 | 0.2581 |
| 78996 | CYREN | PTC01 | Human | Thyroid | PTC | 1.09e-02 | 9.68e-02 | 0.1899 |
| 78996 | CYREN | PTC05 | Human | Thyroid | PTC | 4.70e-03 | 1.52e-01 | 0.2065 |
| 78996 | CYREN | PTC06 | Human | Thyroid | PTC | 3.41e-10 | 2.37e-01 | 0.2057 |
| 78996 | CYREN | PTC07 | Human | Thyroid | PTC | 5.11e-12 | 2.40e-01 | 0.2044 |
| 78996 | CYREN | ATC09 | Human | Thyroid | ATC | 1.77e-08 | 3.43e-01 | 0.2871 |
| 78996 | CYREN | ATC12 | Human | Thyroid | ATC | 4.25e-14 | 3.11e-01 | 0.34 |
| 78996 | CYREN | ATC13 | Human | Thyroid | ATC | 5.96e-08 | 1.48e-01 | 0.34 |
| 78996 | CYREN | ATC1 | Human | Thyroid | ATC | 4.49e-08 | 3.69e-01 | 0.2878 |
| 78996 | CYREN | ATC2 | Human | Thyroid | ATC | 9.20e-14 | 7.74e-01 | 0.34 |
| 78996 | CYREN | ATC4 | Human | Thyroid | ATC | 1.37e-20 | 4.26e-01 | 0.34 |
| 78996 | CYREN | ATC5 | Human | Thyroid | ATC | 1.29e-07 | 1.74e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:005105221 | Liver | HCC | regulation of DNA metabolic process | 198/7958 | 359/18723 | 7.62e-07 | 1.17e-05 | 198 |
| GO:200102021 | Liver | HCC | regulation of response to DNA damage stimulus | 128/7958 | 219/18723 | 1.31e-06 | 1.90e-05 | 128 |
| GO:00062824 | Liver | HCC | regulation of DNA repair | 74/7958 | 130/18723 | 6.27e-04 | 3.89e-03 | 74 |
| GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
| GO:0002200 | Liver | HCC | somatic diversification of immune receptors | 44/7958 | 77/18723 | 6.70e-03 | 2.72e-02 | 44 |
| GO:2000779 | Liver | HCC | regulation of double-strand break repair | 47/7958 | 85/18723 | 1.17e-02 | 4.28e-02 | 47 |
| GO:0016445 | Liver | HCC | somatic diversification of immunoglobulins | 38/7958 | 67/18723 | 1.32e-02 | 4.73e-02 | 38 |
| GO:005105218 | Thyroid | PTC | regulation of DNA metabolic process | 171/5968 | 359/18723 | 2.52e-10 | 8.33e-09 | 171 |
| GO:2001020112 | Thyroid | PTC | regulation of response to DNA damage stimulus | 113/5968 | 219/18723 | 9.37e-10 | 2.77e-08 | 113 |
| GO:00062828 | Thyroid | PTC | regulation of DNA repair | 65/5968 | 130/18723 | 1.25e-05 | 1.36e-04 | 65 |
| GO:20010216 | Thyroid | PTC | negative regulation of response to DNA damage stimulus | 44/5968 | 81/18723 | 2.34e-05 | 2.33e-04 | 44 |
| GO:20007794 | Thyroid | PTC | regulation of double-strand break repair | 42/5968 | 85/18723 | 5.59e-04 | 3.56e-03 | 42 |
| GO:00063026 | Thyroid | PTC | double-strand break repair | 103/5968 | 251/18723 | 1.30e-03 | 7.40e-03 | 103 |
| GO:2001032 | Thyroid | PTC | regulation of double-strand break repair via nonhomologous end joining | 17/5968 | 29/18723 | 2.65e-03 | 1.35e-02 | 17 |
| GO:00063032 | Thyroid | PTC | double-strand break repair via nonhomologous end joining | 32/5968 | 66/18723 | 3.55e-03 | 1.71e-02 | 32 |
| GO:00510532 | Thyroid | PTC | negative regulation of DNA metabolic process | 53/5968 | 125/18723 | 8.39e-03 | 3.53e-02 | 53 |
| GO:00022004 | Thyroid | PTC | somatic diversification of immune receptors | 35/5968 | 77/18723 | 8.56e-03 | 3.59e-02 | 35 |
| GO:00164453 | Thyroid | PTC | somatic diversification of immunoglobulins | 31/5968 | 67/18723 | 9.51e-03 | 3.91e-02 | 31 |
| GO:00164473 | Thyroid | PTC | somatic recombination of immunoglobulin gene segments | 27/5968 | 57/18723 | 1.04e-02 | 4.18e-02 | 27 |
| GO:005105219 | Thyroid | ATC | regulation of DNA metabolic process | 183/6293 | 359/18723 | 5.97e-12 | 2.30e-10 | 183 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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