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Gene: CYP4B1 |
Gene summary for CYP4B1 |
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Gene information | Species | Human | Gene symbol | CYP4B1 | Gene ID | 1580 |
Gene name | cytochrome P450 family 4 subfamily B member 1 | |
Gene Alias | CYPIVB1 | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | P13584 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1580 | CYP4B1 | C46 | Human | Oral cavity | OSCC | 7.22e-20 | 6.11e-01 | 0.1673 |
1580 | CYP4B1 | LN46 | Human | Oral cavity | OSCC | 6.97e-24 | 1.14e+00 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066317 | Oral cavity | OSCC | fatty acid metabolic process | 186/7305 | 390/18723 | 2.65e-04 | 1.69e-03 | 186 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYP4B1 | SNV | Missense_Mutation | rs139611523 | c.880N>T | p.Arg294Trp | p.R294W | P13584 | protein_coding | deleterious(0.01) | benign(0.05) | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CYP4B1 | SNV | Missense_Mutation | novel | c.695N>C | p.Tyr232Ser | p.Y232S | P13584 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CYP4B1 | SNV | Missense_Mutation | novel | c.694N>C | p.Tyr232His | p.Y232H | P13584 | protein_coding | tolerated(0.4) | benign(0.091) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
CYP4B1 | SNV | Missense_Mutation | novel | c.1458N>G | p.Ile486Met | p.I486M | P13584 | protein_coding | tolerated(0.07) | benign(0.209) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYP4B1 | SNV | Missense_Mutation | c.1283N>T | p.Ser428Phe | p.S428F | P13584 | protein_coding | deleterious(0) | benign(0.01) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
CYP4B1 | insertion | Frame_Shift_Ins | novel | c.1246_1247insGGACTGGAGTTCCCAGCTTTCCTTTCTCCTGCTCACCCTCTGGTGG | p.Asn416ArgfsTer24 | p.N416Rfs*24 | P13584 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CYP4B1 | insertion | Nonsense_Mutation | novel | c.117_118insCCACGCCAGTGAACACATGAATGATAAAAAAGCAAAACA | p.Leu39_Ala40insProArgGlnTerThrHisGluTerTerLysSerLysThr | p.L39_A40insPRQ*THE**KSKT | P13584 | protein_coding | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
CYP4B1 | deletion | Frame_Shift_Del | novel | c.269delG | p.Gly90AlafsTer3 | p.G90Afs*3 | P13584 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CYP4B1 | SNV | Missense_Mutation | novel | c.179N>T | p.Glu60Val | p.E60V | P13584 | protein_coding | tolerated(0.07) | possibly_damaging(0.784) | TCGA-ZJ-AB0I-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CYP4B1 | SNV | Missense_Mutation | c.607N>T | p.Gly203Cys | p.G203C | P13584 | protein_coding | tolerated(1) | benign(0.003) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1580 | CYP4B1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | thalidomide | THALIDOMIDE | 20038957 | |
1580 | CYP4B1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | DEXTRAN SULFATE | 15039297 | ||
1580 | CYP4B1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | docetaxel | DOCETAXEL | 20038957 | |
1580 | CYP4B1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | TCDD | 2829388 |
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