![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CYP27C1 |
Gene summary for CYP27C1 |
![]() |
Gene information | Species | Human | Gene symbol | CYP27C1 | Gene ID | 339761 |
Gene name | cytochrome P450 family 27 subfamily C member 1 | |
Gene Alias | CYP27C1 | |
Cytomap | 2q14.3 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | A0A024RAI7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339761 | CYP27C1 | HCC2_Meng | Human | Liver | HCC | 7.64e-06 | 6.34e-02 | 0.0107 |
339761 | CYP27C1 | HCC1 | Human | Liver | HCC | 2.87e-12 | 1.15e+00 | 0.5336 |
339761 | CYP27C1 | HCC2 | Human | Liver | HCC | 1.13e-24 | 1.72e+00 | 0.5341 |
339761 | CYP27C1 | HCC5 | Human | Liver | HCC | 2.06e-08 | 9.14e-01 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000606621 | Liver | HCC | alcohol metabolic process | 208/7958 | 353/18723 | 2.80e-10 | 9.50e-09 | 208 |
GO:000608112 | Liver | HCC | cellular aldehyde metabolic process | 39/7958 | 60/18723 | 3.61e-04 | 2.50e-03 | 39 |
GO:000672011 | Liver | HCC | isoprenoid metabolic process | 65/7958 | 116/18723 | 2.23e-03 | 1.11e-02 | 65 |
GO:003430812 | Liver | HCC | primary alcohol metabolic process | 55/7958 | 102/18723 | 1.30e-02 | 4.67e-02 | 55 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYP27C1 | SNV | Missense_Mutation | c.926N>C | p.Ile309Thr | p.I309T | Q4G0S4 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYP27C1 | insertion | Nonsense_Mutation | novel | c.576_577insTGAAGTTCG | p.Thr192_Val193insTer | p.T192_V193ins* | Q4G0S4 | protein_coding | TCGA-AO-A03O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
CYP27C1 | insertion | Frame_Shift_Ins | novel | c.574_575insGGCTGGGGCAAGAGAATCG | p.Thr192ArgfsTer39 | p.T192Rfs*39 | Q4G0S4 | protein_coding | TCGA-AO-A03O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
CYP27C1 | insertion | Frame_Shift_Ins | novel | c.79_80insTACACCAAACATA | p.Ala27ValfsTer6 | p.A27Vfs*6 | Q4G0S4 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
CYP27C1 | insertion | Nonsense_Mutation | novel | c.78_79insAAACAATAAAGGGTA | p.Ile26_Ala27insLysGlnTerArgVal | p.I26_A27insKQ*RV | Q4G0S4 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
CYP27C1 | insertion | Nonsense_Mutation | novel | c.250_251insCAGTGCTTAAAATGTAGAGTTTCAGGTC | p.Tyr84SerfsTer6 | p.Y84Sfs*6 | Q4G0S4 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
CYP27C1 | SNV | Missense_Mutation | novel | c.871N>A | p.Pro291Thr | p.P291T | Q4G0S4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CYP27C1 | SNV | Missense_Mutation | novel | c.373G>A | p.Gly125Arg | p.G125R | Q4G0S4 | protein_coding | tolerated(0.29) | possibly_damaging(0.908) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CYP27C1 | SNV | Missense_Mutation | novel | c.761A>G | p.Glu254Gly | p.E254G | Q4G0S4 | protein_coding | deleterious(0.03) | benign(0.14) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CYP27C1 | SNV | Missense_Mutation | c.1100G>A | p.Arg367Gln | p.R367Q | Q4G0S4 | protein_coding | tolerated(1) | benign(0.019) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |