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Gene: CWF19L1 |
Gene summary for CWF19L1 |
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Gene information | Species | Human | Gene symbol | CWF19L1 | Gene ID | 55280 |
Gene name | CWF19 like cell cycle control factor 1 | |
Gene Alias | C19L1 | |
Cytomap | 10q24.31 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q69YN2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55280 | CWF19L1 | LZE24T | Human | Esophagus | ESCC | 1.80e-05 | 2.00e-01 | 0.0596 |
55280 | CWF19L1 | P2T-E | Human | Esophagus | ESCC | 3.88e-18 | 2.81e-01 | 0.1177 |
55280 | CWF19L1 | P4T-E | Human | Esophagus | ESCC | 9.60e-05 | 1.51e-01 | 0.1323 |
55280 | CWF19L1 | P5T-E | Human | Esophagus | ESCC | 6.52e-13 | 2.51e-01 | 0.1327 |
55280 | CWF19L1 | P8T-E | Human | Esophagus | ESCC | 4.31e-10 | 1.34e-01 | 0.0889 |
55280 | CWF19L1 | P12T-E | Human | Esophagus | ESCC | 5.77e-19 | 1.87e-01 | 0.1122 |
55280 | CWF19L1 | P15T-E | Human | Esophagus | ESCC | 1.46e-06 | 2.06e-01 | 0.1149 |
55280 | CWF19L1 | P16T-E | Human | Esophagus | ESCC | 1.13e-16 | 1.81e-01 | 0.1153 |
55280 | CWF19L1 | P21T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.20e-01 | 0.1617 |
55280 | CWF19L1 | P22T-E | Human | Esophagus | ESCC | 6.27e-07 | 8.74e-02 | 0.1236 |
55280 | CWF19L1 | P23T-E | Human | Esophagus | ESCC | 4.81e-05 | 1.88e-01 | 0.108 |
55280 | CWF19L1 | P24T-E | Human | Esophagus | ESCC | 6.16e-11 | 1.24e-01 | 0.1287 |
55280 | CWF19L1 | P26T-E | Human | Esophagus | ESCC | 1.84e-17 | 2.42e-01 | 0.1276 |
55280 | CWF19L1 | P27T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.93e-01 | 0.1055 |
55280 | CWF19L1 | P28T-E | Human | Esophagus | ESCC | 3.10e-06 | 1.48e-01 | 0.1149 |
55280 | CWF19L1 | P30T-E | Human | Esophagus | ESCC | 5.49e-03 | 1.56e-01 | 0.137 |
55280 | CWF19L1 | P31T-E | Human | Esophagus | ESCC | 1.18e-06 | 1.34e-01 | 0.1251 |
55280 | CWF19L1 | P32T-E | Human | Esophagus | ESCC | 1.21e-08 | 1.46e-01 | 0.1666 |
55280 | CWF19L1 | P36T-E | Human | Esophagus | ESCC | 1.20e-04 | 1.98e-01 | 0.1187 |
55280 | CWF19L1 | P37T-E | Human | Esophagus | ESCC | 5.28e-03 | 1.50e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CWF19L1 | SNV | Missense_Mutation | novel | c.1519N>A | p.Asp507Asn | p.D507N | Q69YN2 | protein_coding | tolerated(0.15) | probably_damaging(0.936) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CWF19L1 | SNV | Missense_Mutation | c.749N>G | p.Asp250Gly | p.D250G | Q69YN2 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
CWF19L1 | SNV | Missense_Mutation | novel | c.253N>A | p.Asp85Asn | p.D85N | Q69YN2 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-WT-AB41-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
CWF19L1 | SNV | Missense_Mutation | rs560724938 | c.905G>A | p.Arg302His | p.R302H | Q69YN2 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CWF19L1 | SNV | Missense_Mutation | c.1327N>A | p.Gln443Lys | p.Q443K | Q69YN2 | protein_coding | tolerated(0.18) | benign(0.051) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CWF19L1 | SNV | Missense_Mutation | c.688G>C | p.Gly230Arg | p.G230R | Q69YN2 | protein_coding | deleterious(0.03) | possibly_damaging(0.813) | TCGA-EK-A2PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
CWF19L1 | SNV | Missense_Mutation | c.1140N>T | p.Glu380Asp | p.E380D | Q69YN2 | protein_coding | tolerated(0.31) | benign(0.083) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
CWF19L1 | SNV | Missense_Mutation | novel | c.619N>C | p.Tyr207His | p.Y207H | Q69YN2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CWF19L1 | SNV | Missense_Mutation | rs746097669 | c.557N>T | p.Thr186Met | p.T186M | Q69YN2 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CWF19L1 | SNV | Missense_Mutation | c.196N>G | p.Gln66Glu | p.Q66E | Q69YN2 | protein_coding | tolerated(0.23) | benign(0.044) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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