Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CTDP1

Gene summary for CTDP1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CTDP1

Gene ID

9150

Gene nameCTD phosphatase subunit 1
Gene AliasCCFDN
Cytomap18q23
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

A0A0A0MR03


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9150CTDP1C04HumanOral cavityOSCC7.00e-032.25e-010.2633
9150CTDP1C30HumanOral cavityOSCC5.37e-165.86e-010.3055
9150CTDP1C43HumanOral cavityOSCC2.00e-041.07e-010.1704
9150CTDP1LN38HumanOral cavityOSCC4.00e-025.27e-010.168
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001603220Oral cavityOSCCviral process274/7305415/187232.42e-291.70e-26274
GO:01400145Oral cavityOSCCmitotic nuclear division191/7305287/187231.99e-213.70e-19191
GO:00447728Oral cavityOSCCmitotic cell cycle phase transition255/7305424/187235.29e-196.98e-17255
GO:001604917Oral cavityOSCCcell growth268/7305482/187236.55e-143.51e-12268
GO:004440320Oral cavityOSCCbiological process involved in symbiotic interaction173/7305290/187236.80e-133.19e-11173
GO:00482852Oral cavityOSCCorganelle fission265/7305488/187233.22e-121.27e-10265
GO:001908010Oral cavityOSCCviral gene expression69/730594/187231.26e-114.44e-1069
GO:000155816Oral cavityOSCCregulation of cell growth228/7305414/187231.74e-116.09e-10228
GO:00002801Oral cavityOSCCnuclear division237/7305439/187239.62e-112.90e-09237
GO:000647015Oral cavityOSCCprotein dephosphorylation162/7305281/187231.56e-104.56e-09162
GO:00063547Oral cavityOSCCDNA-templated transcription, elongation63/730591/187234.86e-091.07e-0763
GO:00163119Oral cavityOSCCdephosphorylation220/7305417/187236.33e-091.34e-07220
GO:00063686Oral cavityOSCCtranscription elongation from RNA polymerase II promoter48/730569/187232.60e-074.05e-0648
GO:00518176Oral cavityOSCCmodulation of process of other organism involved in symbiotic interaction54/730581/187234.22e-076.25e-0654
GO:00459266Oral cavityOSCCnegative regulation of growth135/7305249/187237.29e-071.03e-05135
GO:00190833Oral cavityOSCCviral transcription36/730550/187232.26e-062.87e-0536
GO:00358218Oral cavityOSCCmodulation of process of other organism64/7305106/187236.70e-067.36e-0564
GO:00518517Oral cavityOSCCmodulation by host of symbiont process40/730560/187231.32e-051.33e-0440
GO:00303084Oral cavityOSCCnegative regulation of cell growth101/7305188/187232.85e-052.63e-04101
GO:00517029Oral cavityOSCCbiological process involved in interaction with symbiont54/730594/187232.20e-041.44e-0354
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CTDP1SNVMissense_Mutationnovelc.1909N>Tp.Val637Leup.V637LQ9Y5B0protein_codingtolerated(0.08)possibly_damaging(0.763)TCGA-A8-A07R-01Breastbreast invasive carcinomaFemale>=65III/IVAncillaryzoledronicSD
CTDP1SNVMissense_Mutationc.2269N>Tp.His757Tyrp.H757YQ9Y5B0protein_codingdeleterious(0)probably_damaging(0.911)TCGA-A8-A08H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CTDP1SNVMissense_Mutationrs761298575c.2101N>Ap.Gly701Argp.G701RQ9Y5B0protein_codingtolerated(0.5)benign(0.011)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CTDP1SNVMissense_Mutationrs777188795c.1751N>Tp.Thr584Metp.T584MQ9Y5B0protein_codingtolerated(0.06)possibly_damaging(0.454)TCGA-B6-A0I9-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
CTDP1insertionIn_Frame_Insnovelc.671_672insAAAp.Arg224_Leu225insAsnp.R224_L225insNQ9Y5B0protein_codingTCGA-A7-A0CE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
CTDP1insertionFrame_Shift_Insnovelc.672_673insATGATTCATAATGGCCAAAAGGGGGTTGTp.Leu225MetfsTer46p.L225Mfs*46Q9Y5B0protein_codingTCGA-A7-A0CE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
CTDP1deletionFrame_Shift_Delnovelc.739delNp.Phe247SerfsTer14p.F247Sfs*14Q9Y5B0protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
CTDP1SNVMissense_Mutationnovelc.2293N>Ap.Ala765Thrp.A765TQ9Y5B0protein_codingtolerated(0.21)benign(0.017)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
CTDP1SNVMissense_Mutationnovelc.1357N>Cp.Asp453Hisp.D453HQ9Y5B0protein_codingdeleterious_low_confidence(0.01)possibly_damaging(0.819)TCGA-C5-A8XJ-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinSD
CTDP1SNVMissense_Mutationrs377684676c.1319N>Ap.Arg440Glnp.R440QQ9Y5B0protein_codingtolerated(1)benign(0)TCGA-EK-A2RA-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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