Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CST1

Gene summary for CST1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CST1

Gene ID

1469

Gene namecystatin SN
Gene AliasCST1
Cytomap20p11.21
Gene Typeprotein-coding
GO ID

GO:0001580

UniProtAcc

P01037


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1469CST1P4T-EHumanEsophagusESCC2.11e-112.04e+000.1323
1469CST1P5T-EHumanEsophagusESCC4.41e-072.72e+000.1327
1469CST1HCC5HumanLiverHCC1.75e-084.69e+000.4932
1469CST1S014HumanLiverHCC1.36e-193.19e+000.2254
1469CST1S015HumanLiverHCC1.31e-053.72e+000.2375
1469CST1S016HumanLiverHCC3.59e-263.96e+000.2243
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0052547111EsophagusESCCregulation of peptidase activity275/8552461/187237.54e-101.88e-08275
GO:0052548111EsophagusESCCregulation of endopeptidase activity253/8552432/187233.68e-086.78e-07253
GO:0045861111EsophagusESCCnegative regulation of proteolysis195/8552351/187231.13e-047.85e-04195
GO:0051346110EsophagusESCCnegative regulation of hydrolase activity208/8552379/187231.76e-041.14e-03208
GO:001046620EsophagusESCCnegative regulation of peptidase activity140/8552262/187236.73e-032.46e-02140
GO:001095119EsophagusESCCnegative regulation of endopeptidase activity135/8552252/187236.86e-032.51e-02135
GO:005254722LiverHCCregulation of peptidase activity247/7958461/187238.28e-071.27e-05247
GO:005254822LiverHCCregulation of endopeptidase activity230/7958432/187233.58e-064.68e-05230
GO:004586122LiverHCCnegative regulation of proteolysis186/7958351/187234.19e-054.11e-04186
GO:005134622LiverHCCnegative regulation of hydrolase activity195/7958379/187232.44e-041.82e-03195
GO:001095121LiverHCCnegative regulation of endopeptidase activity129/7958252/187233.17e-031.47e-02129
GO:001046621LiverHCCnegative regulation of peptidase activity132/7958262/187235.82e-032.42e-02132
GO:005254719ProstateTumorregulation of peptidase activity137/3246461/187232.48e-111.71e-09137
GO:005254819ProstateTumorregulation of endopeptidase activity126/3246432/187235.86e-103.01e-08126
GO:004586119ProstateTumornegative regulation of proteolysis102/3246351/187233.09e-089.94e-07102
GO:005134617ProstateTumornegative regulation of hydrolase activity97/3246379/187232.87e-053.46e-0497
GO:001095116ProstateTumornegative regulation of endopeptidase activity68/3246252/187237.91e-058.19e-0468
GO:001046617ProstateTumornegative regulation of peptidase activity70/3246262/187238.76e-058.66e-0470
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CST1SNVMissense_Mutationc.295N>Tp.Pro99Serp.P99SP01037protein_codingtolerated(0.2)benign(0.02)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CST1SNVMissense_Mutationc.114N>Ap.Asp38Glup.D38EP01037protein_codingtolerated(0.08)possibly_damaging(0.64)TCGA-AR-A251-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinSD
CST1SNVMissense_Mutationrs367602743c.370G>Ap.Glu124Lysp.E124KP01037protein_codingtolerated(0.39)probably_damaging(0.973)TCGA-E2-A10C-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
CST1insertionIn_Frame_Insnovelc.70_71insTTCATGATCTAATGCTCAGATTCATTCAGCTTTCCCTGGp.Lys24delinsIleHisAspLeuMetLeuArgPheIleGlnLeuSerLeuGlup.K24delinsIHDLMLRFIQLSLEP01037protein_codingTCGA-AN-A0FS-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
CST1SNVMissense_Mutationc.181N>Cp.Asp61Hisp.D61HP01037protein_codingdeleterious(0)probably_damaging(0.998)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CST1SNVMissense_Mutationnovelc.252N>Ap.Phe84Leup.F84LP01037protein_codingtolerated(0.16)benign(0.3)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
CST1SNVMissense_Mutationrs768059525c.205C>Tp.Arg69Trpp.R69WP01037protein_codingtolerated(0.06)benign(0.117)TCGA-F5-6814-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
CST1SNVMissense_Mutationc.5C>Tp.Ala2Valp.A2VP01037protein_codingdeleterious(0.02)possibly_damaging(0.855)TCGA-A5-A0GP-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
CST1SNVMissense_Mutationrs746147492c.256N>Ap.Asp86Asnp.D86NP01037protein_codingtolerated(0.13)possibly_damaging(0.52)TCGA-AX-A0J0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
CST1SNVMissense_Mutationrs201877331c.196C>Tp.Arg66Cysp.R66CP01037protein_codingdeleterious(0.03)possibly_damaging(0.613)TCGA-AX-A2HC-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapypaclitaxelPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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