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Gene: CRYZL1 |
Gene summary for CRYZL1 |
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Gene information | Species | Human | Gene symbol | CRYZL1 | Gene ID | 9946 |
Gene name | crystallin zeta like 1 | |
Gene Alias | 4P11 | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O95825 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9946 | CRYZL1 | LZE3D | Human | Esophagus | HGIN | 6.17e-04 | 4.98e-01 | 0.0668 |
9946 | CRYZL1 | LZE4T | Human | Esophagus | ESCC | 2.87e-06 | 1.15e-01 | 0.0811 |
9946 | CRYZL1 | LZE7T | Human | Esophagus | ESCC | 1.23e-06 | 1.79e-01 | 0.0667 |
9946 | CRYZL1 | LZE8T | Human | Esophagus | ESCC | 5.11e-06 | 1.02e-01 | 0.067 |
9946 | CRYZL1 | LZE20T | Human | Esophagus | ESCC | 6.10e-12 | 1.74e-01 | 0.0662 |
9946 | CRYZL1 | LZE24T | Human | Esophagus | ESCC | 2.07e-19 | 5.06e-01 | 0.0596 |
9946 | CRYZL1 | LZE21T | Human | Esophagus | ESCC | 7.86e-03 | 9.49e-02 | 0.0655 |
9946 | CRYZL1 | P1T-E | Human | Esophagus | ESCC | 8.15e-05 | 3.11e-01 | 0.0875 |
9946 | CRYZL1 | P2T-E | Human | Esophagus | ESCC | 8.36e-17 | 2.52e-01 | 0.1177 |
9946 | CRYZL1 | P4T-E | Human | Esophagus | ESCC | 1.68e-20 | 4.15e-01 | 0.1323 |
9946 | CRYZL1 | P5T-E | Human | Esophagus | ESCC | 2.33e-16 | 2.67e-01 | 0.1327 |
9946 | CRYZL1 | P8T-E | Human | Esophagus | ESCC | 8.30e-20 | 1.55e-01 | 0.0889 |
9946 | CRYZL1 | P9T-E | Human | Esophagus | ESCC | 3.39e-21 | 1.97e-01 | 0.1131 |
9946 | CRYZL1 | P10T-E | Human | Esophagus | ESCC | 6.19e-25 | 4.34e-01 | 0.116 |
9946 | CRYZL1 | P11T-E | Human | Esophagus | ESCC | 2.46e-10 | 3.02e-01 | 0.1426 |
9946 | CRYZL1 | P12T-E | Human | Esophagus | ESCC | 1.36e-28 | 4.56e-01 | 0.1122 |
9946 | CRYZL1 | P15T-E | Human | Esophagus | ESCC | 6.00e-12 | 1.38e-01 | 0.1149 |
9946 | CRYZL1 | P16T-E | Human | Esophagus | ESCC | 2.92e-25 | 3.41e-01 | 0.1153 |
9946 | CRYZL1 | P17T-E | Human | Esophagus | ESCC | 1.67e-04 | 1.97e-01 | 0.1278 |
9946 | CRYZL1 | P19T-E | Human | Esophagus | ESCC | 1.84e-10 | 4.31e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190166112 | Esophagus | ESCC | quinone metabolic process | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:19016613 | Oral cavity | OSCC | quinone metabolic process | 32/7305 | 40/18723 | 1.40e-07 | 2.34e-06 | 32 |
GO:00421804 | Oral cavity | OSCC | cellular ketone metabolic process | 111/7305 | 211/18723 | 3.94e-05 | 3.45e-04 | 111 |
GO:190166111 | Oral cavity | LP | quinone metabolic process | 24/4623 | 40/18723 | 2.17e-06 | 4.85e-05 | 24 |
GO:004218012 | Oral cavity | LP | cellular ketone metabolic process | 70/4623 | 211/18723 | 3.29e-03 | 2.21e-02 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRYZL1 | SNV | Missense_Mutation | c.917A>T | p.Asp306Val | p.D306V | O95825 | protein_coding | deleterious(0) | possibly_damaging(0.642) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
CRYZL1 | SNV | Missense_Mutation | c.860N>G | p.Asp287Gly | p.D287G | O95825 | protein_coding | deleterious(0.02) | benign(0.205) | TCGA-E2-A15P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
CRYZL1 | insertion | In_Frame_Ins | novel | c.957_958insGCGGGGCCGCGTCGGGGGCGG | p.Gln319_Leu320insAlaGlyProArgArgGlyArg | p.Q319_L320insAGPRRGR | O95825 | protein_coding | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CRYZL1 | insertion | Frame_Shift_Ins | novel | c.955_956insGGAACCGGCGGGGGCGG | p.Gln319ArgfsTer48 | p.Q319Rfs*48 | O95825 | protein_coding | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CRYZL1 | SNV | Missense_Mutation | c.739G>A | p.Asp247Asn | p.D247N | O95825 | protein_coding | deleterious(0) | possibly_damaging(0.906) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
CRYZL1 | SNV | Missense_Mutation | rs763694929 | c.391N>T | p.Arg131Cys | p.R131C | O95825 | protein_coding | tolerated(0.17) | benign(0.036) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CRYZL1 | SNV | Missense_Mutation | novel | c.829N>T | p.Leu277Phe | p.L277F | O95825 | protein_coding | deleterious(0) | benign(0.132) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
CRYZL1 | SNV | Missense_Mutation | c.52N>C | p.Val18Leu | p.V18L | O95825 | protein_coding | tolerated(0.18) | benign(0) | TCGA-DM-A1D4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CRYZL1 | SNV | Missense_Mutation | c.578N>A | p.Ala193Asp | p.A193D | O95825 | protein_coding | deleterious(0.04) | benign(0.345) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CRYZL1 | SNV | Missense_Mutation | novel | c.821G>C | p.Cys274Ser | p.C274S | O95825 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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