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Gene: CRYGN |
Gene summary for CRYGN |
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Gene information | Species | Human | Gene symbol | CRYGN | Gene ID | 155051 |
Gene name | crystallin gamma N | |
Gene Alias | CRYGN | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q8WXF5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
155051 | CRYGN | male-WTA | Human | Thyroid | PTC | 3.06e-19 | 1.48e-01 | 0.1037 |
155051 | CRYGN | PTC01 | Human | Thyroid | PTC | 2.22e-24 | 6.39e-01 | 0.1899 |
155051 | CRYGN | PTC05 | Human | Thyroid | PTC | 2.33e-08 | 5.74e-01 | 0.2065 |
155051 | CRYGN | PTC06 | Human | Thyroid | PTC | 7.95e-22 | 6.45e-01 | 0.2057 |
155051 | CRYGN | PTC07 | Human | Thyroid | PTC | 4.04e-26 | 5.99e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRYGN | insertion | Nonsense_Mutation | novel | c.497_498insAGGGATCTAGAACTAGAAATACCATTT | p.Ala166_Thr167insGlyIleTerAsnTerLysTyrHisPhe | p.A166_T167insGI*N*KYHF | Q8WXF5 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CRYGN | insertion | In_Frame_Ins | novel | c.23_24insGTATCAGTTGCAAAACCAGCTGGGCTTTGG | p.Ile8delinsMetTyrGlnLeuGlnAsnGlnLeuGlyPheGly | p.I8delinsMYQLQNQLGFG | Q8WXF5 | protein_coding | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | ||
CRYGN | SNV | Missense_Mutation | rs373827604 | c.220N>T | p.Arg74Cys | p.R74C | Q8WXF5 | protein_coding | tolerated(0.2) | benign(0.024) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRYGN | insertion | Frame_Shift_Ins | novel | c.409dupG | p.Asp137GlyfsTer8 | p.D137Gfs*8 | Q8WXF5 | protein_coding | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CRYGN | SNV | Missense_Mutation | novel | c.340G>A | p.Glu114Lys | p.E114K | Q8WXF5 | protein_coding | deleterious(0.01) | benign(0.068) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CRYGN | SNV | Missense_Mutation | novel | c.66G>T | p.Glu22Asp | p.E22D | Q8WXF5 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CRYGN | SNV | Missense_Mutation | novel | c.230N>T | p.Ser77Ile | p.S77I | Q8WXF5 | protein_coding | deleterious(0) | possibly_damaging(0.776) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CRYGN | SNV | Missense_Mutation | rs538987053 | c.407N>A | p.Gly136Glu | p.G136E | Q8WXF5 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CRYGN | SNV | Missense_Mutation | novel | c.295N>T | p.Ile99Phe | p.I99F | Q8WXF5 | protein_coding | deleterious(0.03) | benign(0.065) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
CRYGN | SNV | Missense_Mutation | novel | c.529N>G | p.Phe177Val | p.F177V | Q8WXF5 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-EC-A24G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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