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Gene: CRLF2 |
Gene summary for CRLF2 |
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Gene information | Species | Human | Gene symbol | CRLF2 | Gene ID | 64109 |
Gene name | cytokine receptor like factor 2 | |
Gene Alias | CRL2 | |
Cytomap | X | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9HC73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64109 | CRLF2 | S027 | Human | Liver | HCC | 2.94e-16 | 8.07e-01 | 0.2446 |
64109 | CRLF2 | S028 | Human | Liver | HCC | 4.40e-18 | 4.96e-01 | 0.2503 |
64109 | CRLF2 | S029 | Human | Liver | HCC | 1.75e-23 | 8.55e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRLF2 | SNV | Missense_Mutation | c.734N>T | p.Ser245Phe | p.S245F | Q9HC73 | protein_coding | tolerated(0.7) | benign(0.003) | TCGA-C8-A12Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
CRLF2 | SNV | Missense_Mutation | c.658N>C | p.Glu220Gln | p.E220Q | Q9HC73 | protein_coding | tolerated(0.31) | benign(0.042) | TCGA-Q1-A6DW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
CRLF2 | SNV | Missense_Mutation | novel | c.659A>G | p.Glu220Gly | p.E220G | Q9HC73 | protein_coding | deleterious(0.01) | benign(0.023) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CRLF2 | insertion | Frame_Shift_Ins | novel | c.524_525insT | p.Leu175PhefsTer103 | p.L175Ffs*103 | Q9HC73 | protein_coding | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CRLF2 | SNV | Missense_Mutation | c.383N>T | p.Ser128Leu | p.S128L | Q9HC73 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-A6-6142-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | PD | |
CRLF2 | SNV | Missense_Mutation | c.716N>T | p.Ala239Val | p.A239V | Q9HC73 | protein_coding | tolerated(1) | benign(0.006) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CRLF2 | SNV | Missense_Mutation | rs759127718 | c.643C>T | p.Arg215Trp | p.R215W | Q9HC73 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRLF2 | SNV | Missense_Mutation | rs759127718 | c.643N>T | p.Arg215Trp | p.R215W | Q9HC73 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CRLF2 | SNV | Missense_Mutation | rs374874204 | c.7N>T | p.Arg3Trp | p.R3W | Q9HC73 | protein_coding | deleterious_low_confidence(0.04) | benign(0.363) | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
CRLF2 | SNV | Missense_Mutation | rs754961260 | c.277G>A | p.Asp93Asn | p.D93N | Q9HC73 | protein_coding | tolerated(0.47) | benign(0.005) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
64109 | CRLF2 | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | JAK INHIBITOR I | 20018760 | ||
64109 | CRLF2 | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | RUXOLITINIB | RUXOLITINIB | 22955920 |
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