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Gene: CRISP3 |
Gene summary for CRISP3 |
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Gene information | Species | Human | Gene symbol | CRISP3 | Gene ID | 10321 |
Gene name | cysteine rich secretory protein 3 | |
Gene Alias | Aeg2 | |
Cytomap | 6p12.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P54108 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10321 | CRISP3 | GSM4909296 | Human | Breast | IDC | 1.11e-28 | 7.13e-01 | 0.1524 |
10321 | CRISP3 | GSM4909304 | Human | Breast | IDC | 1.27e-97 | 1.28e+00 | 0.1636 |
10321 | CRISP3 | GSM4909319 | Human | Breast | IDC | 1.48e-02 | 3.27e-01 | 0.1563 |
10321 | CRISP3 | M1 | Human | Breast | IDC | 3.02e-07 | 2.89e-01 | 0.1577 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRISP3 | SNV | Missense_Mutation | novel | c.349N>A | p.Leu117Ile | p.L117I | P54108 | protein_coding | tolerated(0.71) | benign(0.005) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CRISP3 | SNV | Missense_Mutation | c.802T>A | p.Tyr268Asn | p.Y268N | P54108 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
CRISP3 | SNV | Missense_Mutation | c.222A>T | p.Arg74Ser | p.R74S | P54108 | protein_coding | deleterious(0) | benign(0.185) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CRISP3 | SNV | Missense_Mutation | novel | c.617N>C | p.Val206Ala | p.V206A | P54108 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CRISP3 | SNV | Missense_Mutation | rs759469703 | c.611N>C | p.Leu204Pro | p.L204P | P54108 | protein_coding | tolerated(0.18) | benign(0.046) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CRISP3 | SNV | Missense_Mutation | novel | c.454N>T | p.Pro152Ser | p.P152S | P54108 | protein_coding | deleterious(0.04) | benign(0.359) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRISP3 | SNV | Missense_Mutation | rs766853414 | c.514N>T | p.Leu172Phe | p.L172F | P54108 | protein_coding | tolerated(0.06) | possibly_damaging(0.765) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRISP3 | SNV | Missense_Mutation | novel | c.79N>C | p.Phe27Leu | p.F27L | P54108 | protein_coding | tolerated(1) | benign(0.011) | TCGA-AJ-A3IA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRISP3 | SNV | Missense_Mutation | c.333N>T | p.Lys111Asn | p.K111N | P54108 | protein_coding | tolerated(0.45) | benign(0.001) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CRISP3 | SNV | Missense_Mutation | novel | c.239N>T | p.Ala80Val | p.A80V | P54108 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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