Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: CRIM1

Gene summary for CRIM1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CRIM1

Gene ID

51232

Gene namecysteine rich transmembrane BMP regulator 1
Gene AliasCRIM-1
Cytomap2p22.2
Gene Typeprotein-coding
GO ID

GO:0001503

UniProtAcc

Q9NZV1


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51232CRIM1N_HPV_1HumanCervixN_HPV6.07e-03-1.60e-010.0079
51232CRIM1CCI_2HumanCervixCC2.08e-071.05e+000.5249
51232CRIM1TumorHumanCervixCC2.07e-03-1.87e-010.1241
51232CRIM1L1HumanCervixCC2.80e-02-2.18e-010.0802
51232CRIM1HTA11_3410_2000001011HumanColorectumAD1.43e-30-8.33e-010.0155
51232CRIM1HTA11_2487_2000001011HumanColorectumSER4.89e-13-6.58e-01-0.1808
51232CRIM1HTA11_2951_2000001011HumanColorectumAD4.47e-05-8.38e-010.0216
51232CRIM1HTA11_1938_2000001011HumanColorectumAD1.52e-02-4.71e-01-0.0811
51232CRIM1HTA11_3361_2000001011HumanColorectumAD1.35e-17-8.80e-01-0.1207
51232CRIM1HTA11_83_2000001011HumanColorectumSER1.93e-06-6.18e-01-0.1526
51232CRIM1HTA11_696_2000001011HumanColorectumAD9.80e-28-6.72e-01-0.1464
51232CRIM1HTA11_866_2000001011HumanColorectumAD3.47e-10-5.07e-01-0.1001
51232CRIM1HTA11_1391_2000001011HumanColorectumAD1.30e-14-6.78e-01-0.059
51232CRIM1HTA11_2992_2000001011HumanColorectumSER1.40e-02-6.38e-01-0.1706
51232CRIM1HTA11_5216_2000001011HumanColorectumSER7.38e-03-7.24e-01-0.1462
51232CRIM1HTA11_546_2000001011HumanColorectumAD1.87e-02-5.29e-01-0.0842
51232CRIM1HTA11_9341_2000001011HumanColorectumSER3.42e-03-8.85e-01-0.00410000000000005
51232CRIM1HTA11_866_3004761011HumanColorectumAD4.33e-22-7.20e-010.096
51232CRIM1HTA11_4255_2000001011HumanColorectumSER4.98e-02-7.24e-010.0446
51232CRIM1HTA11_9408_2000001011HumanColorectumAD5.06e-03-8.62e-010.0451
Page: 1 2 3 4 5 6 7 8 9 10 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005254710CervixCCregulation of peptidase activity112/2311461/187236.70e-133.08e-10112
GO:005254810CervixCCregulation of endopeptidase activity103/2311432/187231.89e-115.14e-09103
GO:004586110CervixCCnegative regulation of proteolysis80/2311351/187232.88e-081.98e-0680
GO:00513469CervixCCnegative regulation of hydrolase activity81/2311379/187234.27e-071.67e-0581
GO:00104669CervixCCnegative regulation of peptidase activity60/2311262/187231.27e-064.34e-0560
GO:001095110CervixCCnegative regulation of endopeptidase activity56/2311252/187237.43e-061.74e-0456
GO:00071786CervixCCtransmembrane receptor protein serine/threonine kinase signaling pathway67/2311355/187232.39e-042.67e-0367
GO:00016497CervixCCosteoblast differentiation47/2311229/187232.88e-043.11e-0347
GO:0045667CervixCCregulation of osteoblast differentiation29/2311132/187231.32e-031.05e-0229
GO:00015037CervixCCossification71/2311408/187231.67e-031.28e-0271
GO:005254824CervixN_HPVregulation of endopeptidase activity36/534432/187239.74e-091.72e-0636
GO:005254724CervixN_HPVregulation of peptidase activity36/534461/187235.15e-085.59e-0636
GO:004586124CervixN_HPVnegative regulation of proteolysis27/534351/187233.27e-061.36e-0427
GO:001095123CervixN_HPVnegative regulation of endopeptidase activity21/534252/187231.21e-054.05e-0421
GO:001046623CervixN_HPVnegative regulation of peptidase activity21/534262/187232.18e-056.16e-0421
GO:005134624CervixN_HPVnegative regulation of hydrolase activity25/534379/187239.66e-051.97e-0325
GO:000717821CervixN_HPVtransmembrane receptor protein serine/threonine kinase signaling pathway22/534355/187235.85e-047.73e-0322
GO:000164913CervixN_HPVosteoblast differentiation14/534229/187236.22e-034.28e-0214
GO:000150312CervixN_HPVossification21/534408/187236.98e-034.61e-0221
GO:0052547ColorectumADregulation of peptidase activity137/3918461/187234.12e-061.12e-04137
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CRIM1SNVMissense_Mutationc.565G>Ap.Glu189Lysp.E189KQ9NZV1protein_codingtolerated(0.13)benign(0.432)TCGA-A8-A06Q-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
CRIM1SNVMissense_Mutationc.1595G>Tp.Cys532Phep.C532FQ9NZV1protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AN-A0FS-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
CRIM1SNVMissense_Mutationc.1904N>Ap.Arg635Glnp.R635QQ9NZV1protein_codingtolerated(0.16)possibly_damaging(0.667)TCGA-BH-A0HI-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
CRIM1SNVMissense_Mutationc.1061N>Ap.Cys354Tyrp.C354YQ9NZV1protein_codingdeleterious(0)probably_damaging(0.999)TCGA-E2-A14Z-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexPD
CRIM1SNVMissense_Mutationc.1837N>Ap.Gly613Serp.G613SQ9NZV1protein_codingdeleterious(0.01)probably_damaging(1)TCGA-EW-A1P6-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
CRIM1SNVMissense_Mutationnovelc.337A>Cp.Asn113Hisp.N113HQ9NZV1protein_codingtolerated(0.17)benign(0.259)TCGA-OL-A66I-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
CRIM1insertionFrame_Shift_Insnovelc.1539_1540insAGATTTGTATTTTATAAGAATTTGTATTTATTCACTCAp.Leu514ArgfsTer14p.L514Rfs*14Q9NZV1protein_codingTCGA-A8-A07J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
CRIM1insertionNonsense_Mutationnovelc.1592_1593insCTCACACCTGTAACCCCAGCACTTp.Glu531delinsAspSerHisLeuTerProGlnHisLeup.E531delinsDSHL*PQHLQ9NZV1protein_codingTCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
CRIM1deletionIn_Frame_Delnovelc.343_366delNNNNNNNNNNNNNNNNNNNNNNNNp.Thr115_Phe122delp.T115_F122delQ9NZV1protein_codingTCGA-E2-A14R-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinPD
CRIM1deletionFrame_Shift_Delnovelc.645delNp.Gly216AlafsTer12p.G216Afs*12Q9NZV1protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
Page: 1 2 3 4 5 6 7 8 9 10 11 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1