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Gene: CREG1 |
Gene summary for CREG1 |
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Gene information | Species | Human | Gene symbol | CREG1 | Gene ID | 8804 |
Gene name | cellular repressor of E1A stimulated genes 1 | |
Gene Alias | CREG | |
Cytomap | 1q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O75629 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8804 | CREG1 | LZE2T | Human | Esophagus | ESCC | 1.07e-08 | 1.22e+00 | 0.082 |
8804 | CREG1 | LZE4T | Human | Esophagus | ESCC | 1.66e-11 | 8.57e-01 | 0.0811 |
8804 | CREG1 | LZE5T | Human | Esophagus | ESCC | 2.58e-03 | -1.00e-01 | 0.0514 |
8804 | CREG1 | LZE8T | Human | Esophagus | ESCC | 2.64e-02 | -3.83e-01 | 0.067 |
8804 | CREG1 | LZE22D1 | Human | Esophagus | HGIN | 1.12e-04 | -2.08e-01 | 0.0595 |
8804 | CREG1 | LZE22T | Human | Esophagus | ESCC | 2.78e-02 | 4.47e-01 | 0.068 |
8804 | CREG1 | LZE24T | Human | Esophagus | ESCC | 3.21e-14 | 5.60e-01 | 0.0596 |
8804 | CREG1 | LZE22D3 | Human | Esophagus | HGIN | 3.51e-02 | 1.76e-01 | 0.0653 |
8804 | CREG1 | LZE6T | Human | Esophagus | ESCC | 6.28e-03 | -1.58e-01 | 0.0845 |
8804 | CREG1 | P2T-E | Human | Esophagus | ESCC | 6.62e-50 | 1.00e+00 | 0.1177 |
8804 | CREG1 | P4T-E | Human | Esophagus | ESCC | 1.40e-43 | 1.53e+00 | 0.1323 |
8804 | CREG1 | P5T-E | Human | Esophagus | ESCC | 7.56e-18 | 6.06e-01 | 0.1327 |
8804 | CREG1 | P8T-E | Human | Esophagus | ESCC | 1.21e-36 | 7.48e-01 | 0.0889 |
8804 | CREG1 | P9T-E | Human | Esophagus | ESCC | 4.40e-40 | 1.46e+00 | 0.1131 |
8804 | CREG1 | P10T-E | Human | Esophagus | ESCC | 9.60e-57 | 1.23e+00 | 0.116 |
8804 | CREG1 | P11T-E | Human | Esophagus | ESCC | 1.89e-11 | 1.20e+00 | 0.1426 |
8804 | CREG1 | P12T-E | Human | Esophagus | ESCC | 1.26e-33 | 6.34e-01 | 0.1122 |
8804 | CREG1 | P15T-E | Human | Esophagus | ESCC | 4.84e-64 | 2.20e+00 | 0.1149 |
8804 | CREG1 | P16T-E | Human | Esophagus | ESCC | 5.52e-39 | 9.93e-01 | 0.1153 |
8804 | CREG1 | P17T-E | Human | Esophagus | ESCC | 5.54e-06 | 4.96e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CREG1 | SNV | Missense_Mutation | novel | c.611G>A | p.Gly204Asp | p.G204D | O75629 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CREG1 | SNV | Missense_Mutation | novel | c.638N>G | p.Glu213Gly | p.E213G | O75629 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CREG1 | SNV | Missense_Mutation | novel | c.424N>T | p.Pro142Ser | p.P142S | O75629 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CREG1 | SNV | Missense_Mutation | c.622N>C | p.Ile208Leu | p.I208L | O75629 | protein_coding | tolerated(0.58) | benign(0.047) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CREG1 | SNV | Missense_Mutation | novel | c.548N>T | p.Ser183Phe | p.S183F | O75629 | protein_coding | deleterious(0.02) | possibly_damaging(0.829) | TCGA-EY-A1GD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CREG1 | SNV | Missense_Mutation | novel | c.492G>A | p.Met164Ile | p.M164I | O75629 | protein_coding | tolerated(0.39) | benign(0.005) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CREG1 | SNV | Missense_Mutation | c.388N>C | p.Ala130Pro | p.A130P | O75629 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CREG1 | SNV | Missense_Mutation | novel | c.416G>A | p.Gly139Glu | p.G139E | O75629 | protein_coding | tolerated(1) | benign(0.161) | TCGA-L9-A743-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | taxotere | CR |
CREG1 | SNV | Missense_Mutation | novel | c.610N>T | p.Gly204Cys | p.G204C | O75629 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-QK-A8Z8-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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