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Gene: CPNE9 |
Gene summary for CPNE9 |
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Gene information | Species | Human | Gene symbol | CPNE9 | Gene ID | 151835 |
Gene name | copine family member 9 | |
Gene Alias | CPNE9 | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8IYJ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
151835 | CPNE9 | S014 | Human | Liver | HCC | 1.59e-08 | 5.10e-01 | 0.2254 |
151835 | CPNE9 | S015 | Human | Liver | HCC | 1.76e-03 | 3.40e-01 | 0.2375 |
151835 | CPNE9 | S016 | Human | Liver | HCC | 8.59e-14 | 5.39e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:001003822 | Liver | HCC | response to metal ion | 208/7958 | 373/18723 | 1.35e-07 | 2.56e-06 | 208 |
GO:006056011 | Liver | HCC | developmental growth involved in morphogenesis | 124/7958 | 234/18723 | 7.37e-04 | 4.47e-03 | 124 |
GO:007124112 | Liver | HCC | cellular response to inorganic substance | 119/7958 | 226/18723 | 1.26e-03 | 6.92e-03 | 119 |
GO:005159221 | Liver | HCC | response to calcium ion | 81/7958 | 149/18723 | 2.26e-03 | 1.13e-02 | 81 |
GO:199013811 | Liver | HCC | neuron projection extension | 92/7958 | 172/18723 | 2.31e-03 | 1.14e-02 | 92 |
GO:004858811 | Liver | HCC | developmental cell growth | 121/7958 | 234/18723 | 2.68e-03 | 1.28e-02 | 121 |
GO:003030711 | Liver | HCC | positive regulation of cell growth | 88/7958 | 166/18723 | 3.95e-03 | 1.74e-02 | 88 |
GO:007124812 | Liver | HCC | cellular response to metal ion | 101/7958 | 197/18723 | 7.82e-03 | 3.10e-02 | 101 |
GO:004592711 | Liver | HCC | positive regulation of growth | 128/7958 | 259/18723 | 1.41e-02 | 4.99e-02 | 128 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPNE9 | SNV | Missense_Mutation | c.395N>C | p.Lys132Thr | p.K132T | Q8IYJ1 | protein_coding | tolerated(0.1) | benign(0.091) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
CPNE9 | deletion | Frame_Shift_Del | c.671delN | p.Tyr224SerfsTer22 | p.Y224Sfs*22 | Q8IYJ1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
CPNE9 | SNV | Missense_Mutation | novel | c.623N>A | p.Arg208Gln | p.R208Q | Q8IYJ1 | protein_coding | tolerated(0.53) | probably_damaging(0.965) | TCGA-VS-A9UM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CPNE9 | SNV | Missense_Mutation | novel | c.568N>A | p.Glu190Lys | p.E190K | Q8IYJ1 | protein_coding | deleterious(0.01) | benign(0.344) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CPNE9 | SNV | Missense_Mutation | rs775201502 | c.1432N>T | p.Arg478Cys | p.R478C | Q8IYJ1 | protein_coding | deleterious(0.03) | probably_damaging(0.972) | TCGA-5M-AAT5-01 | Colorectum | colon adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown |
CPNE9 | SNV | Missense_Mutation | c.664G>A | p.Asp222Asn | p.D222N | Q8IYJ1 | protein_coding | tolerated(0.11) | benign(0.102) | TCGA-A6-5666-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CPNE9 | SNV | Missense_Mutation | c.1420G>T | p.Gly474Cys | p.G474C | Q8IYJ1 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CPNE9 | SNV | Missense_Mutation | rs755372206 | c.1456G>A | p.Ala486Thr | p.A486T | Q8IYJ1 | protein_coding | deleterious(0) | possibly_damaging(0.737) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPNE9 | SNV | Missense_Mutation | novel | c.118C>A | p.Leu40Ile | p.L40I | Q8IYJ1 | protein_coding | deleterious(0.02) | benign(0.271) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
CPNE9 | SNV | Missense_Mutation | c.103G>A | p.Asp35Asn | p.D35N | Q8IYJ1 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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