|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: CPNE7 |
Gene summary for CPNE7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CPNE7 | Gene ID | 27132 |
| Gene name | copine 7 | |
| Gene Alias | CPNE7 | |
| Cytomap | 16q24.3 | |
| Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9UBL6 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 27132 | CPNE7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 2.21e-01 | 0.0216 |
| 27132 | CPNE7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.63e-02 | 1.16e-01 | -0.059 |
| 27132 | CPNE7 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.51e-05 | 1.58e-01 | 0.096 |
| 27132 | CPNE7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.67e-03 | 1.33e-01 | 0.0338 |
| 27132 | CPNE7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.56e-07 | 1.76e-01 | 0.0674 |
| 27132 | CPNE7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.24e-29 | 5.36e-01 | 0.294 |
| 27132 | CPNE7 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.91e-05 | 2.12e-01 | 0.281 |
| 27132 | CPNE7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.67e-33 | 8.17e-01 | 0.3859 |
| 27132 | CPNE7 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.16e-14 | 4.46e-01 | 0.2585 |
| 27132 | CPNE7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.56e-26 | 4.48e-01 | 0.3005 |
| 27132 | CPNE7 | F007 | Human | Colorectum | FAP | 9.14e-05 | 2.88e-01 | 0.1176 |
| 27132 | CPNE7 | A001-C-207 | Human | Colorectum | FAP | 2.75e-02 | 1.83e-01 | 0.1278 |
| 27132 | CPNE7 | A015-C-203 | Human | Colorectum | FAP | 3.85e-03 | 2.15e-01 | -0.1294 |
| 27132 | CPNE7 | A002-C-201 | Human | Colorectum | FAP | 3.61e-02 | 2.03e-01 | 0.0324 |
| 27132 | CPNE7 | A002-C-203 | Human | Colorectum | FAP | 4.07e-04 | 2.23e-01 | 0.2786 |
| 27132 | CPNE7 | A002-C-021 | Human | Colorectum | FAP | 1.82e-03 | 1.24e-01 | 0.1171 |
| 27132 | CPNE7 | A015-C-006 | Human | Colorectum | FAP | 3.48e-02 | 2.62e-01 | -0.0994 |
| 27132 | CPNE7 | A001-C-007 | Human | Colorectum | CRC | 1.09e-06 | 3.76e-01 | 0.1899 |
| 27132 | CPNE7 | F034 | Human | Colorectum | FAP | 8.62e-04 | 2.32e-01 | -0.0665 |
| 27132 | CPNE7 | F072B | Human | Colorectum | FAP | 3.61e-02 | 1.82e-01 | 0.257 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
| GO:0071248 | Colorectum | AD | cellular response to metal ion | 61/3918 | 197/18723 | 5.74e-04 | 6.09e-03 | 61 |
| GO:0071241 | Colorectum | AD | cellular response to inorganic substance | 68/3918 | 226/18723 | 6.98e-04 | 7.10e-03 | 68 |
| GO:00100382 | Colorectum | MSS | response to metal ion | 90/3467 | 373/18723 | 3.76e-03 | 2.76e-02 | 90 |
| GO:00712412 | Colorectum | MSS | cellular response to inorganic substance | 57/3467 | 226/18723 | 7.27e-03 | 4.64e-02 | 57 |
| GO:0051592 | Colorectum | FAP | response to calcium ion | 33/2622 | 149/18723 | 4.52e-03 | 3.08e-02 | 33 |
| GO:00100384 | Colorectum | FAP | response to metal ion | 70/2622 | 373/18723 | 5.95e-03 | 3.75e-02 | 70 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CPNE7 | SNV | Missense_Mutation | rs368685442 | c.1405N>A | p.Val469Met | p.V469M | Q9UBL6 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AC-A62Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CPNE7 | SNV | Missense_Mutation | rs369886930 | c.667G>A | p.Glu223Lys | p.E223K | Q9UBL6 | protein_coding | deleterious(0.02) | possibly_damaging(0.877) | TCGA-DS-A5RQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
| CPNE7 | SNV | Missense_Mutation | c.1133N>A | p.Gly378Asp | p.G378D | Q9UBL6 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| CPNE7 | SNV | Missense_Mutation | rs141048497 | c.430G>A | p.Ala144Thr | p.A144T | Q9UBL6 | protein_coding | tolerated(0.48) | benign(0) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| CPNE7 | SNV | Missense_Mutation | rs369027383 | c.1462N>A | p.Val488Met | p.V488M | Q9UBL6 | protein_coding | tolerated(0.08) | probably_damaging(0.99) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| CPNE7 | SNV | Missense_Mutation | novel | c.1589N>G | p.Glu530Gly | p.E530G | Q9UBL6 | protein_coding | deleterious(0.02) | benign(0.142) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
| CPNE7 | SNV | Missense_Mutation | c.1126N>T | p.Met376Leu | p.M376L | Q9UBL6 | protein_coding | tolerated(0.12) | benign(0.05) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| CPNE7 | SNV | Missense_Mutation | rs533420972 | c.1504N>A | p.Glu502Lys | p.E502K | Q9UBL6 | protein_coding | tolerated(0.25) | benign(0.124) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
| CPNE7 | SNV | Missense_Mutation | novel | c.1610N>C | p.Arg537Pro | p.R537P | Q9UBL6 | protein_coding | deleterious(0.04) | possibly_damaging(0.887) | TCGA-SS-A7HO-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | PD |
| CPNE7 | SNV | Missense_Mutation | novel | c.846N>T | p.Trp282Cys | p.W282C | Q9UBL6 | protein_coding | deleterious(0.01) | probably_damaging(0.955) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
| Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |