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Gene: CPNE2 |
Gene summary for CPNE2 |
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Gene information | Species | Human | Gene symbol | CPNE2 | Gene ID | 221184 |
Gene name | copine 2 | |
Gene Alias | COPN2 | |
Cytomap | 16q13 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96FN4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221184 | CPNE2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.30e-03 | 1.90e-01 | 0.0155 |
221184 | CPNE2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.12e-14 | 5.58e-01 | -0.1808 |
221184 | CPNE2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.40e-10 | 5.23e-01 | -0.0811 |
221184 | CPNE2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.32e-04 | 3.45e-01 | -0.1088 |
221184 | CPNE2 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.52e-24 | 6.62e-01 | -0.1954 |
221184 | CPNE2 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.59e-07 | 4.43e-01 | -0.1526 |
221184 | CPNE2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.11e-14 | 4.83e-01 | -0.1464 |
221184 | CPNE2 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.20e-08 | 3.53e-01 | -0.1001 |
221184 | CPNE2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.53e-09 | 4.54e-01 | -0.059 |
221184 | CPNE2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.41e-04 | 5.44e-01 | -0.1706 |
221184 | CPNE2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.79e-05 | 6.40e-01 | -0.2061 |
221184 | CPNE2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.07e-04 | 4.15e-01 | -0.0842 |
221184 | CPNE2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.55e-07 | 3.89e-01 | 0.096 |
221184 | CPNE2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.18e-04 | 6.25e-01 | 0.0446 |
221184 | CPNE2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.13e-02 | 4.73e-01 | 0.0528 |
221184 | CPNE2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.66e-04 | 5.53e-01 | 0.0131 |
221184 | CPNE2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.51e-02 | 3.00e-01 | 0.0338 |
221184 | CPNE2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.09e-14 | 5.33e-01 | 0.0674 |
221184 | CPNE2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.81e-07 | 4.96e-01 | 0.0588 |
221184 | CPNE2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.53e-14 | 5.27e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
GO:0071248 | Colorectum | AD | cellular response to metal ion | 61/3918 | 197/18723 | 5.74e-04 | 6.09e-03 | 61 |
GO:0071241 | Colorectum | AD | cellular response to inorganic substance | 68/3918 | 226/18723 | 6.98e-04 | 7.10e-03 | 68 |
GO:00100381 | Colorectum | SER | response to metal ion | 84/2897 | 373/18723 | 1.87e-04 | 3.44e-03 | 84 |
GO:00712411 | Colorectum | SER | cellular response to inorganic substance | 52/2897 | 226/18723 | 1.77e-03 | 1.82e-02 | 52 |
GO:00712481 | Colorectum | SER | cellular response to metal ion | 46/2897 | 197/18723 | 2.31e-03 | 2.21e-02 | 46 |
GO:00100382 | Colorectum | MSS | response to metal ion | 90/3467 | 373/18723 | 3.76e-03 | 2.76e-02 | 90 |
GO:00712412 | Colorectum | MSS | cellular response to inorganic substance | 57/3467 | 226/18723 | 7.27e-03 | 4.64e-02 | 57 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:007124117 | Esophagus | ESCC | cellular response to inorganic substance | 125/8552 | 226/18723 | 2.17e-03 | 9.67e-03 | 125 |
GO:001003820 | Oral cavity | OSCC | response to metal ion | 188/7305 | 373/18723 | 4.34e-06 | 5.00e-05 | 188 |
GO:007124115 | Oral cavity | OSCC | cellular response to inorganic substance | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:007124816 | Oral cavity | OSCC | cellular response to metal ion | 93/7305 | 197/18723 | 1.14e-02 | 3.85e-02 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPNE2 | SNV | Missense_Mutation | c.1394T>C | p.Met465Thr | p.M465T | Q96FN4 | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-AR-A1AV-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
CPNE2 | SNV | Missense_Mutation | c.526N>C | p.Asp176His | p.D176H | Q96FN4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
CPNE2 | insertion | Frame_Shift_Ins | novel | c.204_205insTGGATCTCATTTGTTTCTTTCTT | p.Asn69TrpfsTer74 | p.N69Wfs*74 | Q96FN4 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CPNE2 | deletion | Frame_Shift_Del | novel | c.48delC | p.Met17TrpfsTer14 | p.M17Wfs*14 | Q96FN4 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CPNE2 | SNV | Missense_Mutation | novel | c.99G>C | p.Gln33His | p.Q33H | Q96FN4 | protein_coding | tolerated(0.08) | possibly_damaging(0.699) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CPNE2 | SNV | Missense_Mutation | rs748317019 | c.1295N>T | p.Thr432Met | p.T432M | Q96FN4 | protein_coding | tolerated(0.11) | possibly_damaging(0.631) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CPNE2 | SNV | Missense_Mutation | rs760327598 | c.1463N>A | p.Arg488His | p.R488H | Q96FN4 | protein_coding | tolerated(0.06) | benign(0) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPNE2 | SNV | Missense_Mutation | c.1202G>A | p.Cys401Tyr | p.C401Y | Q96FN4 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CPNE2 | SNV | Missense_Mutation | rs768137060 | c.220N>A | p.Ala74Thr | p.A74T | Q96FN4 | protein_coding | tolerated(0.5) | benign(0.013) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CPNE2 | SNV | Missense_Mutation | rs757386451 | c.466G>A | p.Val156Ile | p.V156I | Q96FN4 | protein_coding | tolerated(0.35) | benign(0.001) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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