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Gene: CPB1 |
Gene summary for CPB1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CPB1 | Gene ID | 1360 |
| Gene name | carboxypeptidase B1 | |
| Gene Alias | CPB | |
| Cytomap | 3q24 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P15086 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1360 | CPB1 | GSM4909301 | Human | Breast | IDC | 2.00e-139 | 2.10e+00 | 0.1577 |
| 1360 | CPB1 | GSM4909307 | Human | Breast | IDC | 5.48e-15 | 4.31e-01 | 0.1569 |
| 1360 | CPB1 | GSM4909308 | Human | Breast | IDC | 1.60e-10 | 2.48e-01 | 0.158 |
| 1360 | CPB1 | NCCBC2 | Human | Breast | DCIS | 5.54e-51 | 2.25e+00 | 0.1554 |
| 1360 | CPB1 | HTA12-15-2 | Human | Pancreas | PDAC | 4.12e-54 | -2.58e+00 | 0.2315 |
| 1360 | CPB1 | HTA12-23-1 | Human | Pancreas | PDAC | 3.96e-42 | -2.46e+00 | 0.3405 |
| 1360 | CPB1 | HTA12-25-1 | Human | Pancreas | PDAC | 9.13e-51 | -2.63e+00 | 0.313 |
| 1360 | CPB1 | HTA12-26-1 | Human | Pancreas | PDAC | 1.82e-78 | -2.51e+00 | 0.3728 |
| 1360 | CPB1 | HTA12-29-1 | Human | Pancreas | PDAC | 4.73e-131 | -2.63e+00 | 0.3722 |
| 1360 | CPB1 | HTA12-3-16 | Human | Pancreas | PDAC | 3.28e-14 | -2.63e+00 | 0.1553 |
| 1360 | CPB1 | HTA12-30-1 | Human | Pancreas | PDAC | 2.19e-19 | -2.19e+00 | 0.3671 |
| 1360 | CPB1 | HTA12-32-1 | Human | Pancreas | PDAC | 2.66e-29 | -1.88e+00 | 0.3624 |
| 1360 | CPB1 | HTA12-9-1 | Human | Pancreas | PDAC | 3.17e-76 | -2.46e+00 | 0.1532 |
| 1360 | CPB1 | HTA12-9-2 | Human | Pancreas | PDAC | 5.71e-08 | -2.97e-01 | 0.0835 |
| 1360 | CPB1 | HTA12-9-3 | Human | Pancreas | PDAC | 2.55e-43 | -2.63e+00 | 0.2045 |
| 1360 | CPB1 | 3829-EC | Human | Pancreas | PanIN | 4.53e-45 | -2.05e-01 | 0.009 |
| 1360 | CPB1 | 4347-EC | Human | Pancreas | PanIN | 1.10e-44 | -2.70e-01 | 0.0572 |
| 1360 | CPB1 | 181429 | Human | Pancreas | PDAC | 7.07e-25 | -2.63e+00 | 0.1416 |
| 1360 | CPB1 | 61354830 | Human | Pancreas | PDAC | 1.19e-15 | -2.63e+00 | 0.1458 |
| 1360 | CPB1 | DS20191261Tumor | Human | Pancreas | PDAC | 1.05e-90 | -2.63e+00 | 0.1367 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CPB1 | SNV | Missense_Mutation | c.354N>C | p.Lys118Asn | p.K118N | P15086 | protein_coding | tolerated(0.07) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CPB1 | SNV | Missense_Mutation | rs369536390 | c.403N>A | p.Glu135Lys | p.E135K | P15086 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| CPB1 | SNV | Missense_Mutation | c.1198N>A | p.Glu400Lys | p.E400K | P15086 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CPB1 | SNV | Missense_Mutation | novel | c.97N>A | p.Glu33Lys | p.E33K | P15086 | protein_coding | tolerated(0.22) | benign(0.051) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
| CPB1 | SNV | Missense_Mutation | c.533N>A | p.Arg178Lys | p.R178K | P15086 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| CPB1 | SNV | Missense_Mutation | novel | c.28G>T | p.Val10Leu | p.V10L | P15086 | protein_coding | tolerated(0.84) | benign(0.001) | TCGA-GM-A2DM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
| CPB1 | insertion | Nonsense_Mutation | novel | c.443_444insTTAACCCACCCAAAAGACAAGCAAATAGAAACT | p.Thr148_Phe149insTer | p.T148_F149ins* | P15086 | protein_coding | TCGA-A8-A09B-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
| CPB1 | SNV | Missense_Mutation | rs766816862 | c.454C>T | p.Arg152Cys | p.R152C | P15086 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-A6-A567-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
| CPB1 | SNV | Missense_Mutation | c.457N>T | p.Ala153Ser | p.A153S | P15086 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CPB1 | SNV | Missense_Mutation | rs760474959 | c.455N>A | p.Arg152His | p.R152H | P15086 | protein_coding | deleterious(0.03) | possibly_damaging(0.89) | TCGA-AA-3975-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 1360 | CPB1 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 252166875 | ||
| 1360 | CPB1 | DRUGGABLE GENOME, PROTEASE, ENZYME | US8710232, 7 | |||
| 1360 | CPB1 | DRUGGABLE GENOME, PROTEASE, ENZYME | US8710232, 8 | |||
| 1360 | CPB1 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 252166824 | ||
| 1360 | CPB1 | DRUGGABLE GENOME, PROTEASE, ENZYME | US8710232, 1 |
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