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Gene: CPA2 |
Gene summary for CPA2 |
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Gene information | Species | Human | Gene symbol | CPA2 | Gene ID | 1358 |
Gene name | carboxypeptidase A2 | |
Gene Alias | CPA2 | |
Cytomap | 7q32.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P48052 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1358 | CPA2 | HCC2 | Human | Liver | HCC | 2.78e-04 | 2.47e+00 | 0.5341 |
1358 | CPA2 | S014 | Human | Liver | HCC | 9.78e-04 | 2.28e-01 | 0.2254 |
1358 | CPA2 | S015 | Human | Liver | HCC | 2.75e-17 | 7.50e-01 | 0.2375 |
1358 | CPA2 | S016 | Human | Liver | HCC | 3.60e-05 | 4.41e-01 | 0.2243 |
1358 | CPA2 | HTA12-15-2 | Human | Pancreas | PDAC | 2.63e-53 | -2.40e+00 | 0.2315 |
1358 | CPA2 | HTA12-16-2 | Human | Pancreas | PDAC | 1.94e-05 | -5.69e-01 | 0.0535 |
1358 | CPA2 | HTA12-16-5 | Human | Pancreas | PDAC | 2.99e-24 | -3.45e-01 | 0.047 |
1358 | CPA2 | HTA12-18-3 | Human | Pancreas | PDAC | 7.57e-17 | -3.98e-01 | 0.0716 |
1358 | CPA2 | HTA12-23-1 | Human | Pancreas | PDAC | 1.74e-42 | -2.34e+00 | 0.3405 |
1358 | CPA2 | HTA12-25-1 | Human | Pancreas | PDAC | 2.08e-52 | -2.40e+00 | 0.313 |
1358 | CPA2 | HTA12-26-1 | Human | Pancreas | PDAC | 7.53e-62 | -2.40e+00 | 0.3728 |
1358 | CPA2 | HTA12-29-1 | Human | Pancreas | PDAC | 1.37e-136 | -2.39e+00 | 0.3722 |
1358 | CPA2 | HTA12-3-16 | Human | Pancreas | PDAC | 2.87e-15 | -2.40e+00 | 0.1553 |
1358 | CPA2 | HTA12-30-1 | Human | Pancreas | PDAC | 9.52e-17 | -2.40e+00 | 0.3671 |
1358 | CPA2 | HTA12-32-1 | Human | Pancreas | PDAC | 2.64e-22 | -2.40e+00 | 0.3624 |
1358 | CPA2 | HTA12-9-1 | Human | Pancreas | PDAC | 5.03e-78 | -2.32e+00 | 0.1532 |
1358 | CPA2 | HTA12-9-2 | Human | Pancreas | PDAC | 9.32e-36 | -6.07e-01 | 0.0835 |
1358 | CPA2 | HTA12-9-3 | Human | Pancreas | PDAC | 7.05e-45 | -2.40e+00 | 0.2045 |
1358 | CPA2 | 4347-EC | Human | Pancreas | PanIN | 7.61e-61 | -4.77e-01 | 0.0572 |
1358 | CPA2 | 4741-EC2 | Human | Pancreas | PanIN | 4.98e-08 | 1.02e-01 | 0.0194 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070391 | Liver | HCC | protein catabolic process in the vacuole | 14/7958 | 19/18723 | 5.94e-03 | 2.44e-02 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPA2 | SNV | Missense_Mutation | c.535C>A | p.His179Asn | p.H179N | P48052 | protein_coding | deleterious(0.01) | probably_damaging(0.945) | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CPA2 | SNV | Missense_Mutation | novel | c.503A>T | p.Asp168Val | p.D168V | P48052 | protein_coding | deleterious(0.02) | benign(0.01) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CPA2 | SNV | Missense_Mutation | novel | c.462N>T | p.Glu154Asp | p.E154D | P48052 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CPA2 | SNV | Missense_Mutation | rs145958174 | c.718N>T | p.Arg240Trp | p.R240W | P48052 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CPA2 | SNV | Missense_Mutation | rs777694068 | c.340C>T | p.Arg114Trp | p.R114W | P48052 | protein_coding | tolerated(0.06) | benign(0.047) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CPA2 | SNV | Missense_Mutation | novel | c.1156C>T | p.Arg386Cys | p.R386C | P48052 | protein_coding | deleterious(0.04) | benign(0.07) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CPA2 | SNV | Missense_Mutation | c.240C>A | p.Phe80Leu | p.F80L | P48052 | protein_coding | tolerated(0.08) | benign(0.018) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CPA2 | SNV | Missense_Mutation | novel | c.448N>A | p.Gly150Ser | p.G150S | P48052 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CPA2 | SNV | Missense_Mutation | novel | c.140N>G | p.Gln47Arg | p.Q47R | P48052 | protein_coding | tolerated(0.49) | benign(0.017) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CPA2 | SNV | Missense_Mutation | novel | c.530N>A | p.Gly177Glu | p.G177E | P48052 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1358 | CPA2 | PROTEASE, ENZYME, DRUGGABLE GENOME | asparaginase | ASPARAGINASE | 27114598 |
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