Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: COX18

Gene summary for COX18

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

COX18

Gene ID

285521

Gene namecytochrome c oxidase assembly factor COX18
Gene AliasCOX18HS
Cytomap4q13.3
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

B7ZL88


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
285521COX18HCC1_MengHumanLiverHCC5.32e-157.33e-030.0246
285521COX18HCC2_MengHumanLiverHCC1.63e-034.15e-020.0107
285521COX18HCC1HumanLiverHCC3.01e-101.98e+000.5336
285521COX18HCC2HumanLiverHCC8.24e-141.89e+000.5341
285521COX18HCC5HumanLiverHCC7.35e-037.90e-010.4932
285521COX18S027HumanLiverHCC2.71e-022.50e-010.2446
285521COX18S028HumanLiverHCC7.36e-062.65e-010.2503
285521COX18S029HumanLiverHCC1.49e-062.91e-010.2581
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:007259422LiverHCCestablishment of protein localization to organelle299/7958422/187231.06e-326.10e-30299
GO:000683912LiverHCCmitochondrial transport184/7958254/187232.30e-223.83e-20184
GO:007265512LiverHCCestablishment of protein localization to mitochondrion98/7958120/187231.18e-181.46e-1698
GO:007058512LiverHCCprotein localization to mitochondrion101/7958125/187231.53e-181.86e-16101
GO:003310812LiverHCCmitochondrial respiratory chain complex assembly80/795893/187233.47e-184.15e-1680
GO:009015012LiverHCCestablishment of protein localization to membrane168/7958260/187234.07e-132.13e-11168
GO:000700612LiverHCCmitochondrial membrane organization80/7958116/187237.09e-091.81e-0780
GO:00170041LiverHCCcytochrome complex assembly30/795836/187235.69e-079.03e-0630
GO:00336171LiverHCCmitochondrial cytochrome c oxidase assembly20/795822/187233.00e-063.98e-0520
GO:009015111LiverHCCestablishment of protein localization to mitochondrial membrane25/795830/187235.25e-066.54e-0525
GO:005120511LiverHCCprotein insertion into membrane41/795857/187236.42e-067.83e-0541
GO:00085351LiverHCCrespiratory chain complex IV assembly22/795826/187231.23e-051.39e-0422
GO:005120412LiverHCCprotein insertion into mitochondrial membrane20/795825/187231.47e-041.18e-0320
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0471422LiverHCCThermogenesis170/4020232/84655.36e-162.25e-141.25e-14170
hsa0471432LiverHCCThermogenesis170/4020232/84655.36e-162.25e-141.25e-14170
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
COX18SNVMissense_Mutationrs773178375c.362C>Tp.Thr121Ilep.T121Iprotein_codingtolerated(0.14)benign(0)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
COX18SNVMissense_Mutationrs763271464c.755N>Ap.Arg252Hisp.R252Hprotein_codingdeleterious(0.04)benign(0.077)TCGA-EA-A3HS-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
COX18SNVMissense_Mutationnovelc.871C>Ap.Leu291Ilep.L291Iprotein_codingdeleterious(0.01)probably_damaging(0.951)TCGA-AA-3966-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
COX18SNVMissense_Mutationrs199728913c.485N>Ap.Arg162Glnp.R162Qprotein_codingdeleterious(0.03)probably_damaging(0.992)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
COX18SNVMissense_Mutationrs186168799c.893N>Ap.Arg298Hisp.R298Hprotein_codingtolerated(0.13)probably_damaging(0.93)TCGA-AZ-6601-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
COX18SNVMissense_Mutationc.450N>Tp.Lys150Asnp.K150Nprotein_codingdeleterious(0.05)benign(0.127)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
COX18SNVMissense_Mutationrs777276473c.911N>Gp.Gln304Argp.Q304Rprotein_codingtolerated(1)benign(0)TCGA-EI-6514-01Colorectumrectum adenocarcinomaFemale<65I/IIChemotherapy5-fuSD
COX18insertionIn_Frame_Insnovelc.831_831+1insCCCTCAp.Pro276_Ser277dupp.P276_S277dupprotein_codingTCGA-AG-A032-01Colorectumrectum adenocarcinomaMale>=65III/IVTargeted Molecular therapybevacizumabPD
COX18SNVMissense_Mutationc.365T>Gp.Ile122Serp.I122Sprotein_codingdeleterious(0)possibly_damaging(0.688)TCGA-B5-A11E-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
COX18SNVMissense_Mutationnovelc.425G>Tp.Arg142Ilep.R142Iprotein_codingdeleterious(0)possibly_damaging(0.579)TCGA-B5-A1MR-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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