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Gene: COX18 |
Gene summary for COX18 |
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Gene information | Species | Human | Gene symbol | COX18 | Gene ID | 285521 |
Gene name | cytochrome c oxidase assembly factor COX18 | |
Gene Alias | COX18HS | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B7ZL88 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285521 | COX18 | HCC1_Meng | Human | Liver | HCC | 5.32e-15 | 7.33e-03 | 0.0246 |
285521 | COX18 | HCC2_Meng | Human | Liver | HCC | 1.63e-03 | 4.15e-02 | 0.0107 |
285521 | COX18 | HCC1 | Human | Liver | HCC | 3.01e-10 | 1.98e+00 | 0.5336 |
285521 | COX18 | HCC2 | Human | Liver | HCC | 8.24e-14 | 1.89e+00 | 0.5341 |
285521 | COX18 | HCC5 | Human | Liver | HCC | 7.35e-03 | 7.90e-01 | 0.4932 |
285521 | COX18 | S027 | Human | Liver | HCC | 2.71e-02 | 2.50e-01 | 0.2446 |
285521 | COX18 | S028 | Human | Liver | HCC | 7.36e-06 | 2.65e-01 | 0.2503 |
285521 | COX18 | S029 | Human | Liver | HCC | 1.49e-06 | 2.91e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:007265512 | Liver | HCC | establishment of protein localization to mitochondrion | 98/7958 | 120/18723 | 1.18e-18 | 1.46e-16 | 98 |
GO:007058512 | Liver | HCC | protein localization to mitochondrion | 101/7958 | 125/18723 | 1.53e-18 | 1.86e-16 | 101 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
GO:000700612 | Liver | HCC | mitochondrial membrane organization | 80/7958 | 116/18723 | 7.09e-09 | 1.81e-07 | 80 |
GO:00170041 | Liver | HCC | cytochrome complex assembly | 30/7958 | 36/18723 | 5.69e-07 | 9.03e-06 | 30 |
GO:00336171 | Liver | HCC | mitochondrial cytochrome c oxidase assembly | 20/7958 | 22/18723 | 3.00e-06 | 3.98e-05 | 20 |
GO:009015111 | Liver | HCC | establishment of protein localization to mitochondrial membrane | 25/7958 | 30/18723 | 5.25e-06 | 6.54e-05 | 25 |
GO:005120511 | Liver | HCC | protein insertion into membrane | 41/7958 | 57/18723 | 6.42e-06 | 7.83e-05 | 41 |
GO:00085351 | Liver | HCC | respiratory chain complex IV assembly | 22/7958 | 26/18723 | 1.23e-05 | 1.39e-04 | 22 |
GO:005120412 | Liver | HCC | protein insertion into mitochondrial membrane | 20/7958 | 25/18723 | 1.47e-04 | 1.18e-03 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COX18 | SNV | Missense_Mutation | rs773178375 | c.362C>T | p.Thr121Ile | p.T121I | protein_coding | tolerated(0.14) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
COX18 | SNV | Missense_Mutation | rs763271464 | c.755N>A | p.Arg252His | p.R252H | protein_coding | deleterious(0.04) | benign(0.077) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
COX18 | SNV | Missense_Mutation | novel | c.871C>A | p.Leu291Ile | p.L291I | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COX18 | SNV | Missense_Mutation | rs199728913 | c.485N>A | p.Arg162Gln | p.R162Q | protein_coding | deleterious(0.03) | probably_damaging(0.992) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
COX18 | SNV | Missense_Mutation | rs186168799 | c.893N>A | p.Arg298His | p.R298H | protein_coding | tolerated(0.13) | probably_damaging(0.93) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
COX18 | SNV | Missense_Mutation | c.450N>T | p.Lys150Asn | p.K150N | protein_coding | deleterious(0.05) | benign(0.127) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
COX18 | SNV | Missense_Mutation | rs777276473 | c.911N>G | p.Gln304Arg | p.Q304R | protein_coding | tolerated(1) | benign(0) | TCGA-EI-6514-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fu | SD | |
COX18 | insertion | In_Frame_Ins | novel | c.831_831+1insCCCTCA | p.Pro276_Ser277dup | p.P276_S277dup | protein_coding | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD | |||
COX18 | SNV | Missense_Mutation | c.365T>G | p.Ile122Ser | p.I122S | protein_coding | deleterious(0) | possibly_damaging(0.688) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
COX18 | SNV | Missense_Mutation | novel | c.425G>T | p.Arg142Ile | p.R142I | protein_coding | deleterious(0) | possibly_damaging(0.579) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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