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Gene: COX16 |
Gene summary for COX16 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | COX16 | Gene ID | 51241 |
| Gene name | cytochrome c oxidase assembly factor COX16 | |
| Gene Alias | C14orf112 | |
| Cytomap | 14q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B8XYC5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51241 | COX16 | CCI_3 | Human | Cervix | CC | 3.17e-02 | -2.18e-01 | 0.516 |
| 51241 | COX16 | CCII_1 | Human | Cervix | CC | 4.86e-04 | -2.18e-01 | 0.3249 |
| 51241 | COX16 | sample3 | Human | Cervix | CC | 2.91e-29 | 5.60e-01 | 0.1387 |
| 51241 | COX16 | T3 | Human | Cervix | CC | 1.24e-20 | 5.17e-01 | 0.1389 |
| 51241 | COX16 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.55e-04 | 1.15e-01 | 0.0155 |
| 51241 | COX16 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.03e-09 | 2.97e-01 | -0.1808 |
| 51241 | COX16 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-03 | 2.77e-01 | 0.0216 |
| 51241 | COX16 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.39e-17 | 4.77e-01 | -0.0811 |
| 51241 | COX16 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.26e-09 | 2.39e-01 | -0.1088 |
| 51241 | COX16 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.08e-28 | 4.94e-01 | -0.1954 |
| 51241 | COX16 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.44e-09 | 4.69e-01 | -0.2602 |
| 51241 | COX16 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.91e-05 | 2.21e-01 | -0.1207 |
| 51241 | COX16 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.74e-08 | 3.44e-01 | -0.1526 |
| 51241 | COX16 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.24e-10 | 2.77e-01 | -0.1464 |
| 51241 | COX16 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.73e-11 | 2.41e-01 | -0.1001 |
| 51241 | COX16 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.12e-21 | 4.86e-01 | -0.059 |
| 51241 | COX16 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.52e-06 | 3.19e-01 | -0.2061 |
| 51241 | COX16 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.05e-01 | -0.1462 |
| 51241 | COX16 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.71e-06 | 2.72e-01 | -0.0842 |
| 51241 | COX16 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.45e-14 | 5.24e-01 | -0.0179 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00331089 | Cervix | CC | mitochondrial respiratory chain complex assembly | 26/2311 | 93/18723 | 3.97e-05 | 6.18e-04 | 26 |
| GO:0033108 | Colorectum | AD | mitochondrial respiratory chain complex assembly | 46/3918 | 93/18723 | 8.95e-10 | 6.91e-08 | 46 |
| GO:00331081 | Colorectum | SER | mitochondrial respiratory chain complex assembly | 39/2897 | 93/18723 | 8.13e-10 | 8.74e-08 | 39 |
| GO:00331082 | Colorectum | MSS | mitochondrial respiratory chain complex assembly | 44/3467 | 93/18723 | 2.17e-10 | 2.09e-08 | 44 |
| GO:00331083 | Colorectum | MSI-H | mitochondrial respiratory chain complex assembly | 30/1319 | 93/18723 | 5.71e-13 | 1.27e-10 | 30 |
| GO:003310820 | Esophagus | HGIN | mitochondrial respiratory chain complex assembly | 47/2587 | 93/18723 | 3.15e-17 | 8.60e-15 | 47 |
| GO:00170044 | Esophagus | HGIN | cytochrome complex assembly | 18/2587 | 36/18723 | 2.39e-07 | 1.14e-05 | 18 |
| GO:00336173 | Esophagus | HGIN | mitochondrial cytochrome c oxidase assembly | 13/2587 | 22/18723 | 9.51e-07 | 3.80e-05 | 13 |
| GO:00085353 | Esophagus | HGIN | respiratory chain complex IV assembly | 14/2587 | 26/18723 | 1.68e-06 | 6.29e-05 | 14 |
| GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
| GO:001700413 | Esophagus | ESCC | cytochrome complex assembly | 34/8552 | 36/18723 | 5.08e-10 | 1.31e-08 | 34 |
| GO:000853512 | Esophagus | ESCC | respiratory chain complex IV assembly | 24/8552 | 26/18723 | 6.87e-07 | 8.99e-06 | 24 |
| GO:003361712 | Esophagus | ESCC | mitochondrial cytochrome c oxidase assembly | 21/8552 | 22/18723 | 8.75e-07 | 1.13e-05 | 21 |
| GO:00331087 | Liver | Cirrhotic | mitochondrial respiratory chain complex assembly | 64/4634 | 93/18723 | 3.85e-19 | 7.79e-17 | 64 |
| GO:0017004 | Liver | Cirrhotic | cytochrome complex assembly | 22/4634 | 36/18723 | 3.92e-06 | 6.70e-05 | 22 |
| GO:0033617 | Liver | Cirrhotic | mitochondrial cytochrome c oxidase assembly | 14/4634 | 22/18723 | 1.27e-04 | 1.25e-03 | 14 |
| GO:0008535 | Liver | Cirrhotic | respiratory chain complex IV assembly | 15/4634 | 26/18723 | 3.43e-04 | 2.93e-03 | 15 |
| GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
| GO:00170041 | Liver | HCC | cytochrome complex assembly | 30/7958 | 36/18723 | 5.69e-07 | 9.03e-06 | 30 |
| GO:00336171 | Liver | HCC | mitochondrial cytochrome c oxidase assembly | 20/7958 | 22/18723 | 3.00e-06 | 3.98e-05 | 20 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
| hsa04714110 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
| hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
| hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
| hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
| hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
| hsa047144 | Colorectum | MSS | Thermogenesis | 113/1875 | 232/8465 | 1.52e-19 | 4.62e-18 | 2.83e-18 | 113 |
| hsa047145 | Colorectum | MSS | Thermogenesis | 113/1875 | 232/8465 | 1.52e-19 | 4.62e-18 | 2.83e-18 | 113 |
| hsa047146 | Colorectum | MSI-H | Thermogenesis | 56/797 | 232/8465 | 1.79e-11 | 4.14e-10 | 3.47e-10 | 56 |
| hsa047147 | Colorectum | MSI-H | Thermogenesis | 56/797 | 232/8465 | 1.79e-11 | 4.14e-10 | 3.47e-10 | 56 |
| hsa0471439 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
| hsa04714114 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
| hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
| hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
| hsa0471414 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
| hsa0471415 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
| hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
| hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
| hsa0471430 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
| hsa04714113 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
| Page: 1 2 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| COX16 | deletion | Frame_Shift_Del | novel | c.127delN | p.Ala43LeufsTer2 | p.A43Lfs*2 | Q9P0S2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| COX16 | SNV | Missense_Mutation | novel | c.179N>C | p.Lys60Thr | p.K60T | Q9P0S2 | protein_coding | tolerated(0.23) | benign(0.09) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| COX16 | SNV | Missense_Mutation | rs148696056 | c.194N>T | p.Ser65Leu | p.S65L | Q9P0S2 | protein_coding | deleterious(0) | possibly_damaging(0.877) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| COX16 | SNV | Missense_Mutation | novel | c.105G>T | p.Glu35Asp | p.E35D | Q9P0S2 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| COX16 | SNV | Missense_Mutation | novel | c.62C>T | p.Pro21Leu | p.P21L | Q9P0S2 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| COX16 | SNV | Missense_Mutation | novel | c.284N>T | p.Gly95Val | p.G95V | Q9P0S2 | protein_coding | tolerated(0.08) | benign(0.386) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| COX16 | SNV | Missense_Mutation | rs148696056 | c.194N>T | p.Ser65Leu | p.S65L | Q9P0S2 | protein_coding | deleterious(0) | possibly_damaging(0.877) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
| COX16 | insertion | Frame_Shift_Ins | novel | c.165_166insA | p.Leu56ThrfsTer5 | p.L56Tfs*5 | Q9P0S2 | protein_coding | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| COX16 | SNV | Missense_Mutation | novel | c.257N>T | p.Pro86Leu | p.P86L | Q9P0S2 | protein_coding | tolerated(0.21) | probably_damaging(1) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| COX16 | SNV | Missense_Mutation | c.47T>A | p.Leu16His | p.L16H | Q9P0S2 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-56-6546-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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