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Gene: COQ8B |
Gene summary for COQ8B |
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Gene information | Species | Human | Gene symbol | COQ8B | Gene ID | 79934 |
Gene name | coenzyme Q8B | |
Gene Alias | ADCK4 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006743 | UniProtAcc | A0A024R0Q9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79934 | COQ8B | male-WTA | Human | Thyroid | PTC | 1.44e-12 | 1.23e-01 | 0.1037 |
79934 | COQ8B | PTC01 | Human | Thyroid | PTC | 8.19e-08 | 1.05e-01 | 0.1899 |
79934 | COQ8B | PTC04 | Human | Thyroid | PTC | 2.74e-12 | 1.05e-01 | 0.1927 |
79934 | COQ8B | PTC05 | Human | Thyroid | PTC | 6.87e-08 | 2.63e-01 | 0.2065 |
79934 | COQ8B | PTC06 | Human | Thyroid | PTC | 4.39e-17 | 3.22e-01 | 0.2057 |
79934 | COQ8B | PTC07 | Human | Thyroid | PTC | 4.30e-16 | 2.55e-01 | 0.2044 |
79934 | COQ8B | ATC12 | Human | Thyroid | ATC | 2.62e-02 | 4.78e-02 | 0.34 |
79934 | COQ8B | ATC13 | Human | Thyroid | ATC | 1.53e-43 | 7.61e-01 | 0.34 |
79934 | COQ8B | ATC2 | Human | Thyroid | ATC | 6.34e-06 | 5.11e-01 | 0.34 |
79934 | COQ8B | ATC4 | Human | Thyroid | ATC | 3.61e-02 | 8.81e-02 | 0.34 |
79934 | COQ8B | ATC5 | Human | Thyroid | ATC | 2.40e-47 | 8.12e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COQ8B | SNV | Missense_Mutation | novel | c.495N>A | p.Asn165Lys | p.N165K | Q96D53 | protein_coding | tolerated(0.08) | benign(0.025) | TCGA-EK-A2PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
COQ8B | SNV | Missense_Mutation | c.74N>T | p.Gly25Val | p.G25V | Q96D53 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.861) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
COQ8B | SNV | Missense_Mutation | novel | c.1211T>C | p.Val404Ala | p.V404A | Q96D53 | protein_coding | deleterious(0) | possibly_damaging(0.867) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COQ8B | SNV | Missense_Mutation | c.730G>T | p.Ala244Ser | p.A244S | Q96D53 | protein_coding | deleterious(0.02) | probably_damaging(0.951) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COQ8B | SNV | Missense_Mutation | c.972G>A | p.Met324Ile | p.M324I | Q96D53 | protein_coding | deleterious(0.02) | benign(0.186) | TCGA-D5-7000-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COQ8B | SNV | Missense_Mutation | c.1163N>A | p.Gly388Asp | p.G388D | Q96D53 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DM-A28C-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
COQ8B | SNV | Missense_Mutation | rs201827222 | c.767N>T | p.Ala256Val | p.A256V | Q96D53 | protein_coding | tolerated(0.06) | possibly_damaging(0.455) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COQ8B | SNV | Missense_Mutation | novel | c.583N>A | p.Leu195Ile | p.L195I | Q96D53 | protein_coding | deleterious(0.05) | benign(0.373) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
COQ8B | SNV | Missense_Mutation | rs760868849 | c.457G>A | p.Ala153Thr | p.A153T | Q96D53 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COQ8B | SNV | Missense_Mutation | rs201827222 | c.767N>T | p.Ala256Val | p.A256V | Q96D53 | protein_coding | tolerated(0.06) | possibly_damaging(0.455) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
79934 | COQ8B | KINASE, DRUGGABLE GENOME, ENZYME, TRANSPORTER | Immunoglobulins | 21987091 |
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