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Gene: COQ7 |
Gene summary for COQ7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | COQ7 | Gene ID | 10229 |
| Gene name | coenzyme Q7, hydroxylase | |
| Gene Alias | CAT5 | |
| Cytomap | 16p12.3 | |
| Gene Type | protein-coding | GO ID | GO:0006743 | UniProtAcc | Q99807 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10229 | COQ7 | LZE4T | Human | Esophagus | ESCC | 4.43e-07 | 2.12e-01 | 0.0811 |
| 10229 | COQ7 | LZE7T | Human | Esophagus | ESCC | 2.56e-05 | 2.52e-01 | 0.0667 |
| 10229 | COQ7 | LZE20T | Human | Esophagus | ESCC | 8.28e-08 | 3.12e-01 | 0.0662 |
| 10229 | COQ7 | LZE24T | Human | Esophagus | ESCC | 2.28e-11 | 2.10e-01 | 0.0596 |
| 10229 | COQ7 | LZE21T | Human | Esophagus | ESCC | 1.35e-05 | 2.05e-01 | 0.0655 |
| 10229 | COQ7 | P1T-E | Human | Esophagus | ESCC | 1.04e-16 | 5.93e-01 | 0.0875 |
| 10229 | COQ7 | P2T-E | Human | Esophagus | ESCC | 2.71e-38 | 7.18e-01 | 0.1177 |
| 10229 | COQ7 | P4T-E | Human | Esophagus | ESCC | 2.69e-17 | 3.49e-01 | 0.1323 |
| 10229 | COQ7 | P5T-E | Human | Esophagus | ESCC | 5.86e-12 | 2.24e-01 | 0.1327 |
| 10229 | COQ7 | P8T-E | Human | Esophagus | ESCC | 6.04e-19 | 3.05e-01 | 0.0889 |
| 10229 | COQ7 | P9T-E | Human | Esophagus | ESCC | 2.67e-12 | 1.98e-01 | 0.1131 |
| 10229 | COQ7 | P10T-E | Human | Esophagus | ESCC | 3.55e-13 | 1.72e-01 | 0.116 |
| 10229 | COQ7 | P11T-E | Human | Esophagus | ESCC | 1.22e-03 | 2.59e-01 | 0.1426 |
| 10229 | COQ7 | P12T-E | Human | Esophagus | ESCC | 2.03e-29 | 5.25e-01 | 0.1122 |
| 10229 | COQ7 | P15T-E | Human | Esophagus | ESCC | 2.22e-15 | 3.22e-01 | 0.1149 |
| 10229 | COQ7 | P16T-E | Human | Esophagus | ESCC | 7.90e-34 | 5.16e-01 | 0.1153 |
| 10229 | COQ7 | P17T-E | Human | Esophagus | ESCC | 4.05e-03 | 2.20e-01 | 0.1278 |
| 10229 | COQ7 | P20T-E | Human | Esophagus | ESCC | 7.50e-24 | 5.95e-01 | 0.1124 |
| 10229 | COQ7 | P21T-E | Human | Esophagus | ESCC | 9.64e-26 | 2.68e-01 | 0.1617 |
| 10229 | COQ7 | P22T-E | Human | Esophagus | ESCC | 3.96e-21 | 4.29e-01 | 0.1236 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000756820 | Esophagus | ESCC | aging | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
| GO:190166112 | Esophagus | ESCC | quinone metabolic process | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
| GO:200037718 | Esophagus | ESCC | regulation of reactive oxygen species metabolic process | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
| GO:00067432 | Esophagus | ESCC | ubiquinone metabolic process | 17/8552 | 19/18723 | 9.02e-05 | 6.50e-04 | 17 |
| GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
| GO:00067442 | Esophagus | ESCC | ubiquinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
| GO:19016632 | Esophagus | ESCC | quinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
| GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
| GO:000756818 | Oral cavity | OSCC | aging | 194/7305 | 339/18723 | 6.18e-12 | 2.33e-10 | 194 |
| GO:19016613 | Oral cavity | OSCC | quinone metabolic process | 32/7305 | 40/18723 | 1.40e-07 | 2.34e-06 | 32 |
| GO:200037716 | Oral cavity | OSCC | regulation of reactive oxygen species metabolic process | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
| GO:00421804 | Oral cavity | OSCC | cellular ketone metabolic process | 111/7305 | 211/18723 | 3.94e-05 | 3.45e-04 | 111 |
| GO:0006743 | Oral cavity | OSCC | ubiquinone metabolic process | 16/7305 | 19/18723 | 7.05e-05 | 5.60e-04 | 16 |
| GO:007259316 | Oral cavity | OSCC | reactive oxygen species metabolic process | 122/7305 | 239/18723 | 9.73e-05 | 7.34e-04 | 122 |
| GO:0006744 | Oral cavity | OSCC | ubiquinone biosynthetic process | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
| GO:1901663 | Oral cavity | OSCC | quinone biosynthetic process | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
| GO:0042181 | Oral cavity | OSCC | ketone biosynthetic process | 26/7305 | 43/18723 | 3.55e-03 | 1.49e-02 | 26 |
| GO:000756819 | Oral cavity | LP | aging | 125/4623 | 339/18723 | 3.29e-07 | 9.62e-06 | 125 |
| GO:200037717 | Oral cavity | LP | regulation of reactive oxygen species metabolic process | 67/4623 | 157/18723 | 5.54e-07 | 1.51e-05 | 67 |
| GO:190166111 | Oral cavity | LP | quinone metabolic process | 24/4623 | 40/18723 | 2.17e-06 | 4.85e-05 | 24 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
| hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
| hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
| hsa00130 | Oral cavity | OSCC | Ubiquinone and other terpenoid-quinone biosynthesis | 9/3704 | 11/8465 | 1.19e-02 | 2.62e-02 | 1.33e-02 | 9 |
| hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
| hsa001301 | Oral cavity | OSCC | Ubiquinone and other terpenoid-quinone biosynthesis | 9/3704 | 11/8465 | 1.19e-02 | 2.62e-02 | 1.33e-02 | 9 |
| hsa001302 | Oral cavity | LP | Ubiquinone and other terpenoid-quinone biosynthesis | 8/2418 | 11/8465 | 3.03e-03 | 1.29e-02 | 8.35e-03 | 8 |
| hsa0124021 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
| hsa001303 | Oral cavity | LP | Ubiquinone and other terpenoid-quinone biosynthesis | 8/2418 | 11/8465 | 3.03e-03 | 1.29e-02 | 8.35e-03 | 8 |
| hsa0124031 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| COQ7 | SNV | Missense_Mutation | rs188968280 | c.629N>T | p.Ala210Val | p.A210V | Q99807 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AR-A254-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
| COQ7 | SNV | Missense_Mutation | c.647G>C | p.Arg216Thr | p.R216T | Q99807 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| COQ7 | SNV | Missense_Mutation | rs201474239 | c.592N>A | p.Val198Ile | p.V198I | Q99807 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| COQ7 | SNV | Missense_Mutation | rs373106255 | c.325A>C | p.Thr109Pro | p.T109P | Q99807 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| COQ7 | SNV | Missense_Mutation | rs753589660 | c.464C>T | p.Thr155Met | p.T155M | Q99807 | protein_coding | tolerated(0.1) | benign(0.017) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| COQ7 | SNV | Missense_Mutation | rs777014954 | c.419N>T | p.Ala140Val | p.A140V | Q99807 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| COQ7 | SNV | Missense_Mutation | rs763957708 | c.379N>A | p.Ala127Thr | p.A127T | Q99807 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| COQ7 | SNV | Missense_Mutation | rs749629099 | c.523N>T | p.Arg175Trp | p.R175W | Q99807 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| COQ7 | SNV | Missense_Mutation | novel | c.590C>T | p.Ala197Val | p.A197V | Q99807 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| COQ7 | SNV | Missense_Mutation | rs201819287 | c.178N>A | p.Glu60Lys | p.E60K | Q99807 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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