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Gene: COQ10B |
Gene summary for COQ10B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | COQ10B | Gene ID | 80219 |
| Gene name | coenzyme Q10B | |
| Gene Alias | COQ10B | |
| Cytomap | 2q33.1 | |
| Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | B8ZZX2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 80219 | COQ10B | LZE4T | Human | Esophagus | ESCC | 1.07e-10 | 3.63e-01 | 0.0811 |
| 80219 | COQ10B | LZE5T | Human | Esophagus | ESCC | 1.95e-02 | 2.91e-01 | 0.0514 |
| 80219 | COQ10B | LZE7T | Human | Esophagus | ESCC | 3.97e-05 | 3.79e-01 | 0.0667 |
| 80219 | COQ10B | LZE8T | Human | Esophagus | ESCC | 7.96e-10 | 2.72e-01 | 0.067 |
| 80219 | COQ10B | LZE20T | Human | Esophagus | ESCC | 8.56e-11 | 2.65e-01 | 0.0662 |
| 80219 | COQ10B | LZE22D1 | Human | Esophagus | HGIN | 4.98e-02 | 1.57e-03 | 0.0595 |
| 80219 | COQ10B | LZE22T | Human | Esophagus | ESCC | 1.55e-02 | 2.33e-02 | 0.068 |
| 80219 | COQ10B | LZE24T | Human | Esophagus | ESCC | 5.50e-18 | 6.69e-01 | 0.0596 |
| 80219 | COQ10B | LZE21T | Human | Esophagus | ESCC | 1.12e-08 | 2.70e-01 | 0.0655 |
| 80219 | COQ10B | LZE6T | Human | Esophagus | ESCC | 2.80e-13 | 3.04e-01 | 0.0845 |
| 80219 | COQ10B | P1T-E | Human | Esophagus | ESCC | 1.89e-07 | 4.15e-01 | 0.0875 |
| 80219 | COQ10B | P2T-E | Human | Esophagus | ESCC | 1.82e-18 | 3.64e-01 | 0.1177 |
| 80219 | COQ10B | P4T-E | Human | Esophagus | ESCC | 8.01e-31 | 7.24e-01 | 0.1323 |
| 80219 | COQ10B | P5T-E | Human | Esophagus | ESCC | 4.73e-22 | 3.48e-01 | 0.1327 |
| 80219 | COQ10B | P8T-E | Human | Esophagus | ESCC | 1.22e-27 | 5.52e-01 | 0.0889 |
| 80219 | COQ10B | P9T-E | Human | Esophagus | ESCC | 6.08e-21 | 4.94e-01 | 0.1131 |
| 80219 | COQ10B | P10T-E | Human | Esophagus | ESCC | 5.52e-20 | 2.27e-01 | 0.116 |
| 80219 | COQ10B | P11T-E | Human | Esophagus | ESCC | 2.26e-18 | 9.63e-01 | 0.1426 |
| 80219 | COQ10B | P12T-E | Human | Esophagus | ESCC | 2.36e-24 | 6.59e-01 | 0.1122 |
| 80219 | COQ10B | P15T-E | Human | Esophagus | ESCC | 7.57e-28 | 6.91e-01 | 0.1149 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000609120 | Esophagus | HGIN | generation of precursor metabolites and energy | 145/2587 | 490/18723 | 3.41e-20 | 2.04e-17 | 145 |
| GO:004533320 | Esophagus | HGIN | cellular respiration | 86/2587 | 230/18723 | 2.41e-19 | 1.20e-16 | 86 |
| GO:001598020 | Esophagus | HGIN | energy derivation by oxidation of organic compounds | 105/2587 | 318/18723 | 1.16e-18 | 4.99e-16 | 105 |
| GO:19016614 | Esophagus | HGIN | quinone metabolic process | 13/2587 | 40/18723 | 2.04e-03 | 2.13e-02 | 13 |
| GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
| GO:0045333110 | Esophagus | ESCC | cellular respiration | 173/8552 | 230/18723 | 4.53e-20 | 5.99e-18 | 173 |
| GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
| GO:190166112 | Esophagus | ESCC | quinone metabolic process | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
| GO:00067432 | Esophagus | ESCC | ubiquinone metabolic process | 17/8552 | 19/18723 | 9.02e-05 | 6.50e-04 | 17 |
| GO:00067442 | Esophagus | ESCC | ubiquinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
| GO:19016632 | Esophagus | ESCC | quinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
| GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
| GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
| GO:004533312 | Liver | HCC | cellular respiration | 171/7958 | 230/18723 | 6.35e-23 | 1.26e-20 | 171 |
| GO:001598022 | Liver | HCC | energy derivation by oxidation of organic compounds | 221/7958 | 318/18723 | 1.02e-22 | 1.86e-20 | 221 |
| GO:004218021 | Liver | HCC | cellular ketone metabolic process | 123/7958 | 211/18723 | 2.52e-06 | 3.37e-05 | 123 |
| GO:19016611 | Liver | HCC | quinone metabolic process | 26/7958 | 40/18723 | 3.40e-03 | 1.55e-02 | 26 |
| GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
| GO:004533318 | Oral cavity | OSCC | cellular respiration | 153/7305 | 230/18723 | 2.07e-17 | 1.87e-15 | 153 |
| GO:001598018 | Oral cavity | OSCC | energy derivation by oxidation of organic compounds | 190/7305 | 318/18723 | 4.10e-14 | 2.26e-12 | 190 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| COQ10B | SNV | Missense_Mutation | c.486N>T | p.Glu162Asp | p.E162D | Q9H8M1 | protein_coding | tolerated(0.06) | benign(0.241) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| COQ10B | SNV | Missense_Mutation | c.458N>G | p.Thr153Ser | p.T153S | Q9H8M1 | protein_coding | tolerated(0.23) | benign(0.101) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
| COQ10B | SNV | Missense_Mutation | c.527G>T | p.Arg176Ile | p.R176I | Q9H8M1 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
| COQ10B | SNV | Missense_Mutation | rs776608625 | c.185G>A | p.Arg62Gln | p.R62Q | Q9H8M1 | protein_coding | deleterious(0.04) | possibly_damaging(0.756) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| COQ10B | SNV | Missense_Mutation | rs776608625 | c.185G>A | p.Arg62Gln | p.R62Q | Q9H8M1 | protein_coding | deleterious(0.04) | possibly_damaging(0.756) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
| COQ10B | SNV | Missense_Mutation | novel | c.137N>A | p.Arg46Lys | p.R46K | Q9H8M1 | protein_coding | tolerated(0.13) | benign(0.011) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| COQ10B | SNV | Missense_Mutation | c.206C>T | p.Ala69Val | p.A69V | Q9H8M1 | protein_coding | deleterious(0.04) | benign(0.15) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| COQ10B | SNV | Missense_Mutation | novel | c.447G>T | p.Lys149Asn | p.K149N | Q9H8M1 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| COQ10B | SNV | Missense_Mutation | c.467N>T | p.Arg156Ile | p.R156I | Q9H8M1 | protein_coding | deleterious(0) | benign(0.062) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
| COQ10B | SNV | Missense_Mutation | novel | c.533N>A | p.Cys178Tyr | p.C178Y | Q9H8M1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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